Human-in-the-loop camera control for a mechatronic broadcast boom

IEEE/ASME Transactions on Mechatronics, 12(1): pp. 41-52.Platforms like gantries, booms, aircrafts, and submersibles are often used in the broadcasting industry. To avoid collisions and occlusions, such mechatronic platforms often possess redundant degrees-of-freedom (DOFs). As a result, manual manipulating of such platforms demands much skill. This paper describes the implementation of several controllers that, by using computer vision, attempts to reduce the number of manually manipulated DOFs. Experiments were performed to assess the performance of each controller. A model for such a system was developed and validated. To determine how the visual servoing can improve the tracking, a novice operator and an expert were asked to manually track a moving target with the assistance of visual servoing. The results of these tests were analyzed and compared

3D Complex Structures through Layer Plastic Deposition Designed for Carbon Material Impregnation

The paper aims to demonstrate the capability of LPD – Layer Plastic Deposition 3D printing technique to build complex structures for special purposes such us impregnation with carbon materials. It proposes to push the limits of LPD machines in order to achieve both structural integrity and complexity of the 3D print. Main applicability focus on bioengineering - developing new, lightweight implants and also airspace/automotive industry

Efects of some drying methods on the content in bioactive compounds in sea buckthorn by-products

Recent research has shown that the consumption of sea buckthorn (Hippophae rhamnoides) berries has many benefits for human health. Large amount of waste which result from sea buckthorn berries processing, yet containing significant quantities of bioactive substances, is being the subject of numerous latest research studies. Sea buckthorn by-products represent a valuable source of bioactive compounds that could be used for their favorable nutritional and functional properties in the pharmaceutical, cosmetic and food industries. The aim of this work is to establish a method for drying process of sea buckthorn by-products in order to obtain a powder from dry sea buckthorn waste with minimum loss of the bioactive substances. For this purpose, sea buckthorn by-product (peel and seeds) was dried at different temperatures (30˚C, 40˚C, 50˚C and 60˚C) by conventional hot air drying versus lyophilization method and then the antioxidant activity (DPPH), the content of total polyphenols and ascorbic acid content were determine

Preliminary research on using organic sea buckthorn powder in bread making

Bread is a food product that represents an important element in human nutrition, considered a convenient type of food, being consumed daily in large quantities in many parts of the world. Adding functional ingredients in bakery products was highly researched lately, because of their ability in the reduction of some chronic diseases besides improving of basic nutritional functions. The aim of the present paper was to obtain bread with different quantities of organic dried sea buckthorn powder (Sorana variety), as functional ingredient. For sample characterization, some phisico-chemical (dry matter %, aw) and nutritional parameters (antioxidant activity, total phenolic content) were determined, as well as sensorial analysis. The study obtained promising results regarding the use of sea buckthorn powder as ingredient in bread making

Development of an intervention to expedite cancer diagnosis through primary care: a protocol.

BACKGROUND: GPs can play an important role in achieving earlier cancer diagnosis to improve patient outcomes, for example through prompt use of the urgent suspected cancer referral pathway. Barriers to early diagnosis include individual practitioner variation in knowledge, attitudes, beliefs, professional expectations, and norms. AIM: This programme of work (Wales Interventions and Cancer Knowledge about Early Diagnosis [WICKED]) will develop a behaviour change intervention to expedite diagnosis through primary care and contribute to improved cancer outcomes. DESIGN & SETTING: Non-experimental mixed-method study with GPs and primary care practice teams from Wales. METHOD: Four work packages will inform the development of the behaviour change intervention. Work package 1 will identify relevant evidence-based interventions (systematic review of reviews) and will determine why interventions do or do not work, for whom, and in what circumstances (realist review). Work package 2 will assess cancer knowledge, attitudes, and behaviour of GPs, as well as primary care teams' perspectives on cancer referral and investigation (GP survey, discrete choice experiment [DCE], interviews, and focus groups). Work package 3 will synthesise findings from earlier work packages using the behaviour change wheel as an overarching theoretical framework to guide intervention development. Work package 4 will test the feasibility and acceptability of the intervention, and determine methods for measuring costs and effects of subsequent behaviour change in a randomised feasibility trial. RESULTS: The findings will inform the design of a future effectiveness trial, with concurrent economic evaluation, aimed at earlier diagnosis. CONCLUSION: This comprehensive, evidence-based programme will develop a complex GP behaviour change intervention to expedite the diagnosis of symptomatic cancer, and may be applicable to countries with similar healthcare systems

A Comprehensive Evaluation of Nasal and Bronchial Cytokines and Chemokines Following Experimental Rhinovirus Infection in Allergic Asthma: Increased Interferons (IFN-γ and IFN-λ) and Type 2 Inflammation (IL-5 and IL-13).

BACKGROUND: Rhinovirus infection is a major cause of asthma exacerbations. OBJECTIVES: We studied nasal and bronchial mucosal inflammatory responses during experimental rhinovirus-induced asthma exacerbations. METHODS: We used nasosorption on days 0, 2-5 and 7 and bronchosorption at baseline and day 4 to sample mucosal lining fluid to investigate airway mucosal responses to rhinovirus infection in patients with allergic asthma (n=28) and healthy non-atopic controls (n=11), by using a synthetic absorptive matrix and measuring levels of 34 cytokines and chemokines using a sensitive multiplex assay. RESULTS: Following rhinovirus infection asthmatics developed more upper and lower respiratory symptoms and lower peak expiratory flows compared to controls (all P<0.05). Asthmatics also developed higher nasal lining fluid levels of an anti-viral pathway (including IFN-γ, IFN-λ/IL-29, CXCL11/ITAC, CXCL10/IP10 and IL-15) and a type 2 inflammatory pathway (IL-4, IL-5, IL-13, CCL17/TARC, CCL11/eotaxin, CCL26/eotaxin-3) (area under curve day 0-7, all P<0.05). Nasal IL-5 and IL-13 were higher in asthmatics at day 0 (P<0.01) and levels increased by days 3 and 4 (P<0.01). A hierarchical correlation matrix of 24 nasal lining fluid cytokine and chemokine levels over 7days demonstrated expression of distinct interferon-related and type 2 pathways in asthmatics. In asthmatics IFN-γ, CXCL10/IP10, CXCL11/ITAC, IL-15 and IL-5 increased in bronchial lining fluid following viral infection (all P<0.05). CONCLUSIONS: Precision sampling of mucosal lining fluid identifies robust interferon and type 2 responses in the upper and lower airways of asthmatics during an asthma exacerbation. Nasosorption and bronchosorption have potential to define asthma endotypes in stable disease and at exacerbation

Impact of safety-related dose reductions or discontinuations on sustained virologic response in HCV-infected patients: Results from the GUARD-C Cohort

BACKGROUND: Despite the introduction of direct-acting antiviral agents for chronic hepatitis C virus (HCV) infection, peginterferon alfa/ribavirin remains relevant in many resource-constrained settings. The non-randomized GUARD-C cohort investigated baseline predictors of safety-related dose reductions or discontinuations (sr-RD) and their impact on sustained virologic response (SVR) in patients receiving peginterferon alfa/ribavirin in routine practice. METHODS: A total of 3181 HCV-mono-infected treatment-naive patients were assigned to 24 or 48 weeks of peginterferon alfa/ribavirin by their physician. Patients were categorized by time-to-first sr-RD (Week 4/12). Detailed analyses of the impact of sr-RD on SVR24 (HCV RNA <50 IU/mL) were conducted in 951 Caucasian, noncirrhotic genotype (G)1 patients assigned to peginterferon alfa-2a/ribavirin for 48 weeks. The probability of SVR24 was identified by a baseline scoring system (range: 0-9 points) on which scores of 5 to 9 and <5 represent high and low probability of SVR24, respectively. RESULTS: SVR24 rates were 46.1% (754/1634), 77.1% (279/362), 68.0% (514/756), and 51.3% (203/396), respectively, in G1, 2, 3, and 4 patients. Overall, 16.9% and 21.8% patients experienced 651 sr-RD for peginterferon alfa and ribavirin, respectively. Among Caucasian noncirrhotic G1 patients: female sex, lower body mass index, pre-existing cardiovascular/pulmonary disease, and low hematological indices were prognostic factors of sr-RD; SVR24 was lower in patients with 651 vs. no sr-RD by Week 4 (37.9% vs. 54.4%; P = 0.0046) and Week 12 (41.7% vs. 55.3%; P = 0.0016); sr-RD by Week 4/12 significantly reduced SVR24 in patients with scores <5 but not 655. CONCLUSIONS: In conclusion, sr-RD to peginterferon alfa-2a/ribavirin significantly impacts on SVR24 rates in treatment-naive G1 noncirrhotic Caucasian patients. Baseline characteristics can help select patients with a high probability of SVR24 and a low probability of sr-RD with peginterferon alfa-2a/ribavirin