A Comparison of Polymeric Cable Insulation Properties Following Lightning Impulse Ageing

LDPE and HDPE are common materials used within high voltage insulation systems. These materials will be aged after working under high voltage for a long time. The ageing process of these materials may be affected by external factors. The application of repetitive lightning impulse over-voltages is one of these factors and will be considered in this paper. This paper includes the sample preparation process, the ageing of samples under identical conditions and finally the analysis of electrical properties after the ageing process. The obtained results are used to compare the effect of repetitive lightning impulses with these two materials. These results are also used to highlight the possible mechanisms behind the lighting impulse ageing process

Eclipse Timings of the Transient Low Mass X-ray Binary EXO0748-676. IV. The Rossi X-Ray Timing Explorer Eclipses

We report our complete database of X-ray eclipse timings of the low mass X-ray binary EXO0748-676 observed by the Rossi X-Ray Timing Explorer (RXTE) satellite. As of this writing we have accumulated 443 full X-ray eclipses, 392 of which have been observed with the Proportional Counter Array on RXTE. These include both observations where an eclipse was specifically targeted and those eclipses found in the RXTE data archive. Eclipse cycle count has been maintained since the discovery of the EXO0748-676 system in February 1985. We describe our observing and analysis techniques for each eclipse and describe improvements we have made since the last compilation by Wolff et al. (2002). The principal result of this paper is the database containing the timing results from a seven-parameter fit to the X-ray light curve for each observed eclipse along with the associated errors in the fitted parameters. Based on the standard O-C analysis, EXO0748-676 has undergone four distinct orbital period epochs since its discovery. In addition, EXO0748-676 shows small-scale events in the O-C curve that are likely due to short-lived changes in the secondary star.Comment: Accepted for publication in The Astrophysical Journal Supplement Series, 5 figures. Analysis revised. Tables 1 & 3 update

Estimation of contact resistivity in lightning protection equipotential Bonding joints of wind turbine blades

Modern lightning protection systems for wind turbine blades with conducting structural elements, e.g., carbon fiber reinforced polymer (CFRP) spar caps, contain equipotential bonding joints to prevent sparking during strikes. Significant current levels are experienced through the joints and the characterization of the electrical contact at the bonding regions is essential for reliable protection. Therefore, this article aims to characterize the contact resistivity of several equipotential bonding joints. The proposed methodology first measures the total resistance of the samples, and then the bulk resistance of the conductive elements is computed using the finite-element method. The latter is required to predict the spreading effects in CFRP components due to the strong anisotropic nature of such materials. After that, the contact resistance is calculated by subtracting the predicted bulk resistances from the measured total resistances. The developed procedure was applied to three typical equipotential bonding materials: expanded copper foil (ECF), biaxial (BIAX) CFRP, and unidirectional (UD) CFRP. Both ECF and BIAX CFRP showed superior contact quality than the UD CFRP, with one to two orders of magnitude smaller contact resistivity.</p

Human Immunodeficiency Virus (HIV)-Infected CCR6+ Rectal CD4+ T Cells and HIV Persistence On Antiretroviral Therapy.

BackgroundIdentifying where human immunodeficiency virus (HIV) persists in people living with HIV and receiving antiretroviral therapy is critical to develop cure strategies. We assessed the relationship of HIV persistence to expression of chemokine receptors and their chemokines in blood (n = 48) and in rectal (n = 20) and lymph node (LN; n = 8) tissue collected from people living with HIV who were receiving suppressive antiretroviral therapy.MethodsCell-associated integrated HIV DNA, unspliced HIV RNA, and chemokine messenger RNA were quantified by quantitative polymerase chain reaction. Chemokine receptor expression on CD4+ T cells was determined using flow cytometry.ResultsIntegrated HIV DNA levels in CD4+ T cells, CCR6+CXCR3+ memory CD4+ T-cell frequency, and CCL20 expression (ligand for CCR6) were highest in rectal tissue, where HIV-infected CCR6+ T cells accounted for nearly all infected cells (median, 89.7%). Conversely in LN tissue, CCR6+ T cells were infrequent, and there was a statistically significant association of cell-associated HIV DNA and RNA with CCL19, CCL21, and CXCL13 chemokines.ConclusionsHIV-infected CCR6+ CD4+ T cells accounted for the majority of infected cells in rectal tissue. The different relationships between HIV persistence and T-cell subsets and chemokines in rectal and LN tissue suggest that different tissue-specific strategies may be required to eliminate HIV persistence and that assessment of biomarkers for HIV persistence may not be generalizable between blood and other tissues

Different Transport Pathways of Individual Precursor Proteins in Mitochondria

Transport of mitochondrial precursor proteins into mitochondria of Neurospora crassa was studied in a cellfree reconstituted system. Precursors were synthesized in a reticulocyte lysate programmed with Neurospora mRNA and transported into isolated mitochondria in the absence of protein synthesis. Uptake of the following precursors was investigated: apocytochrome c, ADP/ATP carrier and subunit 9 of the oligomycin-sensitive ATPase. Addition of high concentrations of unlabelled chemically prepared apocytochrome c (1–10 μM) inhibited the appearance in the mitochondrial of labelled cytochrome c synthesized in vitro because the unlabelled protein dilutes the labelled one and because the translocation system has a limited capacity [apparent V is 1–3 pmol × min−1× (mg mitochondrial protein)−1]. Concentrations of added apocytochrome c exceeding the concentrations of precursor proteins synthesized in vitro by a factor of about 104 did not inhibit the transfer of ADP/ATP carrier or ATPase subunit 9 into mitochondria. Carbonylcyanide m-chlorophenylhydrazone, an uncoupler of oxidative phosphorylation, inhibited transfer in vitro of ADP/ATP carrier and of ATPase subunit 9, but not of cytochrome c. These findings suggest that cytochrome c and the other two proteins have different import pathways into mitochondria. It can be inferred from the data presented that different 'receptors' on the mitochondrial surface mediate the specific recognition of precursor proteins by mitochondria as a first step in the transport process

Partial discharge patterns in high voltage insulation

Partial discharge (PD) is an electrical discharge, which does not bridge the electrodes between an insulation system completely under high electric field stress. PD events may affect the performance of insulation system because in long term, it may cause the breakdown of insulation system and failure of high voltage component due to repetition of PD events. In this work, two techniques of analysing PD data have been studied; the phase resolved partial discharge (PRPD) pattern and pulse sequential analysis (PSA) techniques. These two techniques were used to distinguish three main types of PD; they are corona, void and surface discharges. PD data were obtained from the measurement in high voltage laboratory in the University of Southampton, UK. In the end of the analysis, comparison between the PRPD and PSA methods was done to evaluate the advantages and disadvantages between the two techniques

Pathogenicity and immunogenicity of attenuated, nef-deleted HIV-1 strains in vivo

In efforts to develop an effective vaccine, sterilizing immunity to primate lentiviruses has only been achieved by the use of live attenuated viruses carrying major deletions in nef and other accessory genes. Although live attenuated HIV vaccines are unlikely to be developed due to a myriad of safety concerns, opportunities exist to better understand the correlates of immune protection against HIV infection by studying rare cohorts of long-term survivors infected with attenuated, nef-deleted HIV strains such as the Sydney blood bank cohort (SBBC). Here, we review studies of viral evolution, pathogenicity, and immune responses to HIV infection in SBBC members. The studies show that potent, broadly neutralizing anti-HIV antibodies and robust CD8+ T-cell responses to HIV infection were not necessary for long-term control of HIV infection in a subset of SBBC members, and were not sufficient to prevent HIV sequence evolution, augmentation of pathogenicity and eventual progression of HIV infection in another subset. However, a persistent T-helper proliferative response to HIV p24 antigen was associated with long-term control of infection. Together, these results underscore the importance of the host in the eventual outcome of infection. Thus, whilst generating an effective antibody and CD8+ T-cell response are an essential component of vaccines aimed at preventing primary HIV infection, T-helper responses may be important in the generation of an effective therapeutic vaccine aimed at blunting chronic HIV infection

A qualitative understanding of the effects of reusable sanitary pads and puberty education: Implications for future research and practice

BACKGROUND: The management of menstruation has come to the fore as a barrier to girls’ education attainment in low income contexts. Interventions have been proposed and piloted, but the emerging nature of the field means limited evidence is available to understand their pathways of effect. // METHODS: This study describes and compares schoolgirls’ experiences of menstruation in rural Uganda at the conclusion of a controlled trial of puberty education and sanitary pad provision to elucidate pathways of effect in the interventions. Semi-structured interviews were undertaken with schoolgirls who participated in the Menstruation and the Cycle of Poverty trial concurrent with the final set of quantitative surveys. A framework approach and cross-case analysis were employed to describe and compare the experiences of 27 menstruating girls across the four intervention conditions; education (n = 8), reusable sanitary pads (n = 8), education with reusable sanitary pads (n = 6), and control (n = 5). // RESULTS: Themes included: menstrual hygiene, soiling, irritation and infection, physical experience, knowledge of menstruation, psychological, social and cultural factors, and support from others. Those receiving reusable pads experienced improvements in comfort and reliability. This translated into reduced fears around garment soiling and related school absenteeism. Other menstrual hygiene challenges of washing, drying and privacy remained prominent. Puberty education improved girls’ confidence to discuss menstruation and prompted additional support from teachers and peers. // CONCLUSIONS: Findings have important implications for the development and evaluation of future interventions. Results suggest the provision of menstrual absorbents addresses one core barrier to menstrual health, but that interventions addressing broader needs such as privacy may improve effectiveness. Puberty education sessions should increase attention to body awareness and include strategies to address a wider range of practical menstrual challenges, including pain management. Interviews revealed possibilities for improving quantitative surveys in future research

Sustaining entrepreneurial business: a complexity perspective on processes that produce emergent practice

This article examines the management practices in an entrepreneurial small firm which sustain the business. Using a longitudinal qualitative case study, four general processes are identified (experimentation, reflexivity, organising and sensing), that together provide a mechanism to sustain the enterprise. The analysis draws on concepts from entrepreneurship and complexity science. We suggest that an entrepreneur’s awareness of the role of these parallel processes will facilitate their approaches to sustaining and developing enterprises. We also suggest that these processes operate in parallel at multiple levels, including the self, the business and inter-firm networks. This finding contributes to a general theory of entrepreneurship. A number of areas for further research are discussed arising from this result