Determinant Spreading of T Helper Cell 2 (Th2) Responses to Pancreatic Islet Autoantigens

The nature (Th1 versus Th2) and dynamics of the autoimmune response during the development of insulin-dependent diabetes mellitus (IDDM) and after immunotherapy are unclear. Here, we show in nonobese diabetic (NOD) mice that the autoreactive T cell response starts and spreads as a pure Th1 type autoimmunity, suggesting that a spontaneous Th1 cascade underlies disease progression. Surprisingly, induction of antiinflammatory Th2 responses to a single β cell antigen (βCA) resulted in the spreading of Th2 cellular and humoral immunity to unrelated βCAs in an infectious manner and protection from IDDM. The data suggest that both Th1 and Th2 autoimmunity evolve in amplificatory cascades by generating site-specific, but not antigen-specific, positive feedback circuits. Determinant spreading of Th2 responses may be a fundamental mechanism underlying antigen-based immunotherapeutics, explaining observations of infectious tolerance and providing a new theoretical framework for therapeutic intervention

SWAS and Arecibo observations of H2O and OH in a diffuse cloud along the line-of-sight to W51

Observations of W51 with the Submillimeter Wave Astronomy Satellite (SWAS) have yielded the first detection of water vapor in a diffuse molecular cloud. The water vapor lies in a foreground cloud that gives rise to an absorption feature at an LSR velocity of 6 km/s. The inferred H2O column density is 2.5E+13 cm-2. Observations with the Arecibo radio telescope of hydroxyl molecules at ten positions in W51 imply an OH column density of 8E+13 cm-2 in the same diffuse cloud. The observed H2O/OH ratio of ~ 0.3 is significantly larger than an upper limit derived previously from ultraviolet observations of the similar diffuse molecular cloud lying in front of HD 154368. The observed variation in H2O/OH likely points to the presence in one or both of these clouds of a warm (T > 400) gas component in which neutral-neutral reactions are important sources of OH and/or H2O.Comment: 15 pages (AASTeX) including 4 (eps) figures. To appear in the Astrophysical Journa

Inferring individual attributes from search engine queries and auxiliary information

Internet data has surfaced as a primary source for investigation of different aspects of human behavior. A crucial step in such studies is finding a suitable cohort (i.e., a set of users) that shares a common trait of interest to researchers. However, direct identification of users sharing this trait is often impossible, as the data available to researchers is usually anonymized to preserve user privacy. To facilitate research on specific topics of interest, especially in medicine, we introduce an algorithm for identifying a trait of interest in anonymous users. We illustrate how a small set of labeled examples, together with statistical information about the entire population, can be aggregated to obtain labels on unseen examples. We validate our approach using labeled data from the political domain. We provide two applications of the proposed algorithm to the medical domain. In the first, we demonstrate how to identify users whose search patterns indicate they might be suffering from certain types of cancer. In the second, we detail an algorithm to predict the distribution of diseases given their incidence in a subset of the population at study, making it possible to predict disease spread from partial epidemiological data

Opportunities for Public Aquariums to Increase the Sustainability of the Aquatic Animal Trade

The global aquatic pet trade encompasses a wide diversity of freshwater and marine organisms. While relying on a continual supply of healthy, vibrant aquatic animals, few sustainability initiatives exist within this sector. Public aquariums overlap this industry by acquiring many of the same species through the same sources. End users are also similar, as many aquarium visitors are home aquarists. Here we posit that this overlap with the pet trade gives aquariums significant opportunity to increase the sustainability of the trade in aquarium fishes and invertebrates. Improving the sustainability ethos and practices of the aquatic pet trade can carry a conservation benefit in terms of less waste, and protection of intact functioning ecosystems, at the same time as maintaining its economic and educational benefits and impacts. The relationship would also move forward the goal of public aquariums to advance aquatic conservation in a broad sense. For example, many public aquariums in North America have been instrumental in working with the seafood industry to enact positive change toward increased sustainability. The actions include being good consumers themselves, providing technical knowledge, and providing educational and outreach opportunities. These same opportunities exist for public aquariums to partner with the ornamental fish trade, which will serve to improve business, create new, more ethical and more dependable sources of aquatic animals for public aquariums, and perhaps most important, possibly transform the home aquarium industry from a threat, into a positive force for aquatic conservation. Zoo Biol. 32:1-12, 2013. © 2012 Wiley Periodicals, Inc

Stratigraphy and Whole-Rock Amino Acid Geochronology of Key Holocene and Last Interglacial Carbonate Deposits in the Hawaiian Islands

We evaluated the utility of whole-rock amino acid racemization as a method for the stratigraphic correlation and dating of carbonate sediments in the Hawaiian Islands. D-alloisoleucine/L-isoleucine (A/I) ratios were determined for carbonate sand and sandstone samples from 25 localities in the archipelago. The superposition of A/I ratios within stratigraphic sections and the regional concordance of ratios within geological formations support the integrity of the method. To correlate the A/I ratios with an absolute chronology, comparisons were made with previously published uranium series dates on corals and with 14C dates on carbonate sand and organic material, including several new dates reported herein. The A/I mean from four marine isotope stage (MIS) 5e U-series calibration sites was 0.505 ± 0.027 (n = 11), and 12 "test sites" of previously uncertain or speculative geochronological age yielded an A/I mean of 0.445 ± 0.058 (n = 17). Similarly, extensive Holocene dunes on Moloka'i and Kaua'i were correlated by a mean A/I ratio of 0.266 ± 0.022 (n = 8) and equated with a 14C bulk sediment mean age of 8600 yr B.P. Our results indicate that the eolian dunes currently exposed in various localities in the Islands originated primarily during two major periods of dune formation, the last interglacial (MIS 5e) and the early Holocene (MIS 1). MIS 5e and MIS 1 A/I ratios from the Hawaiian Islands show close agreement with previous whole-rock studies in Bermuda and the Bahamas. We discuss these results in terms of their relevance to models of lithospheric flexure and to imposing constraints on the time frame for the extinction of fossil birds

Prospectus, October 26, 1983

LEARNING LAB IS A LIFE SAVER; News Digest; What to do about childhood stress; Braille room fills needs of the blind; PC Happenings; Did you know that?; How to reorganize homemaking chores; TV results; Pumpkin Contest; Health Information; C.A.A.R.; WPCD quizzes high schools; Register for spring semester; Apples remain fave fruit; Be cool in case of fire; Rural Illinois growth increases; Cowboy Brock programs sports; Pulitzer winner visits C-U; Quality circles solve problems; Oktoberfest is today; Around Parkland; The truth behind Halloween is haunting; Brighten a Soldier\u27s Christmas; Interesting story ideas brighten series; Passion at Krannert; Zelig restores Allen\u27s stature; Classified; Krannert adds on; Fast Freddy statistics; Fast Freddy Contest; Bowling scoreshttps://spark.parkland.edu/prospectus_1983/1007/thumbnail.jp

Biomass burning emission inventory with daily resolution: Application to aircraft observations of Asian outflow

Asian outflo

Outcomes after angiography with sodium bicarbonate and acetylcysteine

Background: Intravenous sodium bicarbonate and oral acetylcysteine are widely used to prevent acute kidney injury and associated adverse outcomes after angiography without definitive evidence of their efficacy. Methods: Using a 2-by-2 factorial design, we randomly assigned 5177 patients at high risk for renal complications who were scheduled for angiography to receive intravenous 1.26% sodium bicarbonate or intravenous 0.9% sodium chloride and 5 days of oral acetylcysteine or oral placebo; of these patients, 4993 were included in the modified intention-to-treat analysis. The primary end point was a composite of death, the need for dialysis, or a persistent increase of at least 50% from baseline in the serum creatinine level at 90 days. Contrast-associated acute kidney injury was a secondary end point. Results: The sponsor stopped the trial after a prespecified interim analysis. There was no interaction between sodium bicarbonate and acetylcysteine with respect to the primary end point (P=0.33). The primary end point occurred in 110 of 2511 patients (4.4%) in the sodium bicarbonate group as compared with 116 of 2482 (4.7%) in the sodium chloride group (odds ratio, 0.93; 95% confidence interval [CI], 0.72 to 1.22; P=0.62) and in 114 of 2495 patients (4.6%) in the acetylcysteine group as compared with 112 of 2498 (4.5%) in the placebo group (odds ratio, 1.02; 95% CI, 0.78 to 1.33; P=0.88). There were no significant between-group differences in the rates of contrast-associated acute kidney injury. Conclusions: Among patients at high risk for renal complications who were undergoing angiography, there was no benefit of intravenous sodium bicarbonate over intravenous sodium chloride or of oral acetylcysteine over placebo for the prevention of death, need for dialysis, or persistent decline in kidney function at 90 days or for the prevention of contrast-associated acute kidney injury. (Funded by the U.S. Department of Veterans Affairs Office of Research and Development and the National Health and Medical Research Council of Australia; PRESERVE ClinicalTrials.gov number, NCT01467466.