The role of D-serine and glycine as co-agonists of NMDA receptors in motor neuron degeneration and amyotrophic lateral sclerosis (ALS).

The fundamental role of D-serine as a co-agonist at the N-methyl-D-aspartate receptor (NMDAR), mediating both physiological actions of glutamate in long term potentiation and nociception and also pathological effects mediated by excitotoxicty, are well-established. More recently, a direct link to a chronic neurodegenerative disease, amyotrophic lateral sclerosis/motor neuron disease (ALS) has been suggested by findings that D-serine levels are elevated in sporadic ALS and the G93A SOD1 model of ALS (Sasabe et al., 2007, 2012) and that a pathogenic mutation (R199W) in the enzyme that degrades D-serine, D-amino acid oxidase (DAO), co-segregates with disease in familial ALS (Mitchell et al., 2010). Moreover, D-serine, its biosynthetic enzyme, serine racemase (SR) and DAO are abundant in human spinal cord and severely depleted in ALS. Using cell culture models, we have defined the effects of R199W-DAO, and shown that it activates autophagy, leads to the formation of ubiquitinated aggregates and promotes apoptosis, all of which processes are attenuated by a D-serine/glycine site NMDAR antagonist. These studies provide considerable insight into the crosstalk between neurons and glia and also into potential therapeutic approaches for ALS

Infinite products involving binary digit sums

Let $(u_n)_{n\ge 0}$ denote the Thue-Morse sequence with values $\pm 1$. The Woods-Robbins identity below and several of its generalisations are well-known in the literature \begin{equation*}\label{WR}\prod_{n=0}^\infty\left(\frac{2n+1}{2n+2}\right)^{u_n}=\frac{1}{\sqrt 2}.\end{equation*} No other such product involving a rational function in $n$ and the sequence $u_n$ seems to be known in closed form. To understand these products in detail we study the function \begin{equation*}f(b,c)=\prod_{n=1}^\infty\left(\frac{n+b}{n+c}\right)^{u_n}.\end{equation*} We prove some analytical properties of $f$. We also obtain some new identities similar to the Woods-Robbins product.Comment: Accepted in Proc. AMMCS 2017, updated according to the referees' comment

QED and relativistic corrections in superheavy elements

In this paper we review the different relativistic and QED contributions to energies, ionic radii, transition probabilities and Land\'e $g$-factors in super-heavy elements, with the help of the MultiConfiguration Dirac-Fock method (MCDF). The effects of taking into account the Breit interaction to all orders by including it in the self-consistent field process are demonstrated. State of the art radiative corrections are included in the calculation and discussed. We also study the non-relativistic limit of MCDF calculation and find that the non-relativistic offset can be unexpectedly large.Comment: V3, May 31st, 200

Estimating Percent Residue Cover Using the Line-Transect Method

Leaving crop residue on the soil surface is one of the easiest and most cost-effective methods of reducing soil erosion. Research in Nebraska and other midwestern states has shown that leaving as little as 20 percent of the soil surface covered with crop residue can reduce soil erosion by one-half of what it would be from residue-free conditions. Greater amounts of residue cover will further reduce erosion. Many Conservation Plans specify crop residue management or residue left on the soil surface as the primary erosion control method. Generally, the amount of cover required after planting ranges from 30 percent to as much as 85 percent. Thus, it is important to accurately determine percent residue cover to verify effective erosion control and compliance with a Conservation Plan. Residue cover cannot be estimated merely by looking across a field. Such estimates, often attempted from the road or edge of the field, grossly overestimate the actual amount of cover. Accurate estimates of residue cover can only be obtained from measurements taken within the field, while looking straight down at the soil and residue. Crop residue management, or leaving residue on the soil surface, is the most cost-effective method of reducing soil erosion available to Nebraska farmers. Accurate measurements of percent residue cover are needed to determine if enough cover is present to adequately reduce erosion and to comply with a Conservation Plan. The line-transect method is one of the easiest and most accurate methods of determining percent residue cover

Industrial and organisational psychology

Industrial and organisational (I/0) psychology is concerned with people’s work-related values, attitudes and behaviours, and how these are influenced by the conditions in which they work. I/O psychologists contribute to both the effectiveness of organisations (e.g. improving productivity) and the health and well-being of people working within organisations. The field is related to other disciplines, such as organisational behaviour and human resource management, and also has close links with other sub-disciplines within psychology, especially social psychology and some aspects of human experimental psychology (e.g. cognition)

Low-energy gamma rays from Cygnus X-1

The Cyg X-1 was observed by the balloonborne telescope OPALE, in June 1976. The high energy spectrum of the source, which was in its superlow state, was seen to extend well beyond 1 MeV. The observed low energy gamma ray component of Cyg X-1 is compared with the predictions of recent models involving accretion onto a stellar black hole, and including a possible contribution from the pair annihilation 511 keV gamma ray line