An Overview of the Karst Areas in British Columbia, Canada

Karst is a three-dimensional landscape that occurs in soluble bedrock (typically limestone, marble, dolostone, gypsum or halite) and is defined by a solutionally weathered surface, a subsurface drainage system (where conduit-flow dominates), and underground openings and caves. Karst can host unique flora and subsurface fauna, as well as a wide range of other scientific, recreational and cultural values. Karst and potential karst areas underlie approximately 10% of British Columbia (BC), but the distribution and extent of this landscape has yet to be fully explored and delineated. Some of the most extensive and well-developed karst areas occur within the forestedlimestone areas of coastal BC, such as on Vancouver Island and Haida Gwaii, where numerous surface karst features and caves are known. Karst in the interior plateau regions of British Columbia is less well known, being in part covered by thick deposits of glacial materials. Alpine karst regions are most apparent in the Rocky Mountains where there are limestone plateaus, karst drainages and cave systems that have close connections to past and present glacial systems. Mapping of karst is a critical component for any land-use or resource development activity in all regions of British Columbia, as the environmental impacts on karst and its associated values are potentially significant. The regional distribution of karst in BC is not well mapped, with only an office-based reconnaissance karst potential map (1:250,000-scale) and a related database completed in 1999. A renewed effort should now be made to better map karst across British Columbia using digital bedrock mapping data released in 2017, combined with more recent satellite imagery and improved field knowledge.RÉSUMÉLe karst est un paysage tridimensionnel qui se présente dans le substrat rocheux soluble (généralement calcaire, marbre, dolomite, gypse ou halite) et est défini par une surface altérée par dissolution, un système de drainage souterrain (où l’écoulement par conduit domine) et des ouvertures et cavernes souterraines. Le karst peut abriter une flore et une faune souterraine unique, ainsi qu’une grande variété d’autres ressources scientifiques, de loisir et culturelles. Les zones karstiques et potentiellement karstiques constituent environ 10% de la surface de la Colombie-Britannique, mais la répartition et l’étendue de ce paysage n’a pas été complètement explorées et circonscrites. Certaines des zones karstiques les plus étendues et les mieux développées se trouvent dans les calcaires des zones calcaires boisées de la côte de la Colombie-Britannique, telles que l’île de Vancouver et l’archipel de Haida Gwaii, où l’on connaît de nombreuses caractéristiques karstiques de surface et des cavernes. Le karst des régions des plateaux intérieurs de la Colombie-Britannique est moins bien connu, étant en partie recouvert d’épais dépôts de matériaux glaciaires. Les régions karstiques alpines sont plus apparentes dans les montagnes Rocheuses où se trouvent des plateaux calcaires, des bassins de drainage karstiques et des systèmes de cavernes étroitement liés aux systèmes glaciaires passés et contemporains. La cartographie du karst est une constituante essentielle de toute activité d’utilisation du terrain ou de développement des ressources dans toutes les régions de la Colombie-Britannique, car les impacts environnementaux sur le karst et ses bénéfices associés sont potentiellement importants. La distribution régionale et les caractéristiques des karsts en Colombie-Britannique ne sont pas bien cartographiées, avec seulement une carte de reconnaissance du potentiel karstique établie par une étude de bureau (à l’échelle de 1/250 000) et une base de données associée, complétées en 1999. Il faut aujourd’hui améliorer la cartographie de karsts en Colombie-Britannique en utilisant les données numériques de cartographie du substrat rocheux publiées en 2017, combinées avec des images satellite plus récentes et à une meilleure connaissance du terrain

Framework for a technology-watch relay station

At the centre of the PRIME Faraday Partnership’s Technology Watch service is a growing series of technology and market reviews for managers and engineers in small and medium-sized enterprises (SMEs) producing ‘smart’ products. Its aim is to help them maintain their awareness of new technologies and markets and thereby seize opportunities to innovate they might otherwise miss. The service has attracted considerable interest among users and observers. In this paper the authors outline the process behind the development of Technology Watch’s library of publications with a view to encouraging others to critique and adapt it for deployment in other industrial sectors

Multi-rotor unmanned aerial vehicles (UVAs) and high-resolution compact digital cameras: a promising new method for monitoring changes to surface karst resources

In the course of doctoral research, the authors required a quick and accurate means of documenting the real-time state of surface karst features at a variety of scales in remote and challenging field conditions. The main difficulty was finding an aerial platform that was 1) consistently effective; 2) versatile; and 3) relatively inexpensive. High resolution vertical images obtained during recreational use of a small multi-rotor unmanned aerial vehicle (UAV) seemed to have the potential to answer this need. Using five case studies, the authors examine the potential of these images for mapping, documenting, and monitoring changes to surface karst resources following forestry-related activities in the coastal temperate rainforest of British Columbia (B.C.). Possible applications, strengths and limitations of this technology are discussed. The authors conclude that mini quadcopter UAVs equipped with high-resolution compact digital cameras are a promising and cost-effective new tool for karst scientists and karst managers

Peat deposits of Ohio: their origin, formation and uses

In cooperation with the United States Bureau of Mines

A systematic review of loneliness in bereavement:Current research and future directions

Bereaved people suffer from loneliness and loneliness is associated with poor mental health. In this study, this topic is reviewed. An agenda is suggested for future research. Research that is theory-driven, addresses measurement consistency, correlates of loneliness in bereaved and non-bereaved, and treatment is necessary for prevention and intervention

Executive Functions and Prefrontal Cortex: A Matter of Persistence?

Executive function is thought to originates from the dynamics of frontal cortical networks. We examined the dynamic properties of the blood oxygen level dependent time-series measured with functional MRI (fMRI) within the prefrontal cortex (PFC) to test the hypothesis that temporally persistent neural activity underlies performance in three tasks of executive function. A numerical estimate of signal persistence, the Hurst exponent, postulated to represent the coherent firing of cortical networks, was determined and correlated with task performance. Increasing persistence in the lateral PFC was shown to correlate with improved performance during an n-back task. Conversely, we observed a correlation between persistence and increasing commission error – indicating a failure to inhibit a prepotent response – during a Go/No-Go task. We propose that persistence within the PFC reflects dynamic network formation and these findings underline the importance of frequency analysis of fMRI time-series in the study of executive functions

Towards functional 3D-stacked electrospun composite scaffolds of PHBV, silk fibroin and nanohydroxyapatite: mechanical properties and surface osteogenic differentiation

Bone tissue engineering scaffolds have two challenging functional tasks to fulfil: to encourage cell proliferation, differentiation and matrix synthesis, and to provide suitable mechanical stability upon implantation. Composites of biopolymers and bioceramics combine the advantages of both types of materials, resulting in better processability, and enhanced mechanical and biological properties through matrix reinforcement. In the present study novel thick bone composite scaffolds were successfully fabricated using electrospun flat sheets of polyhydroxybutyrate - polyhydroxyvalerate (PHBV)/ nanohydroxyapatite (nHAp)/ silk fibroin essence (SF) (2% nHAp - 2% SF and 5% nHAp - 5% SF, respectively). Their potential as in vitro bone regeneration scaffolds was evaluated using mouse calvarian osteoblast cells (MC3T3-E1), in terms of morphology (SEM), cell attachment, cell proliferation, Col type I ( COL I), osteopontin (OSPN), and bone alkaline phosphatase (ALP) activity (Quantitative Real Time Polymerase Chain Reaction [qRT-PCR], enzyme linked immunosorbent assay, immunocytochemistry). Electrospun polyhydroxybutyrate–polyhydroxyvalerate scaffolds were used as reference constructs. The results showed that the compressive and tensile mechanical properties of the scaffolds are dependent on the change in their composition, and the treatment these underwent. Furthermore, methanol-treated and autoclaved P2 (2% nanohydroxyapatite, 2% silk fibroin essence) samples appeared to exhibit more promising tensile properties. Additionally, the compressive tests results confirmed that the methanol pre-treatment and the autoclaving step lead to an increase in the P2 secant modulus when compared to the non-methanol treated ones, P2 and P5 (5% nanohydroxyapatite, 5% silk fibroin essence), respectively. Both formulations of polyhydroxybutyrate–polyhydroxyvalerate/nanohydroxyapatite/silk fibroin essence composite promoted greater cell adhesion and proliferation than the corresponding polyhydroxybutyrate–polyhydroxyvalerate control ones. Cells seeded on the composite fibrous scaffolds were extensively expanded and elongated on the fibre surface after 1 day in culture, whereas those seeded on the polyhydroxybutyrate–polyhydroxyvalerate scaffolds were not completely elongated. In addition, cells grown on P2 and P5 scaffolds had higher ALP activity when compared to those containing no nanohydroxyapatite/silk fibroin

Surface polaritons on left-handed cylinders: A complex angular momentum analysis

We consider the scattering of electromagnetic waves by a left-handed cylinder -- i.e., by a cylinder fabricated from a left-handed material -- in the framework of complex angular momentum techniques. We discuss both the TE and TM theories. We emphasize more particularly the resonant aspects of the problem linked to the existence of surface polaritons. We prove that the long-lived resonant modes can be classified into distinct families, each family being generated by one surface polariton propagating close to the cylinder surface and we physically describe all the surface polaritons by providing, for each one, its dispersion relation and its damping. This can be realized by noting that each surface polariton corresponds to a particular Regge pole of the $S$ matrix of the cylinder. Moreover, for both polarizations, we find that there exists a particular surface polariton which corresponds, in the large-radius limit, to the surface polariton which is supported by the plane interface. There exists also an infinite family of surface polaritons of whispering-gallery type which have no analogs in the plane interface case and which are specific to left-handed materials.Comment: published version. v3: reference list correcte

Neuronal pentraxins mediate synaptic refinement in the developing visual system

Peer reviewedPublisher PD

Exploiting macrophage autophagy-lysosomal biogenesis as a therapy for atherosclerosis

Macrophages specialize in removing lipids and debris present in the atherosclerotic plaque. However, plaque progression renders macrophages unable to degrade exogenous atherogenic material and endogenous cargo including dysfunctional proteins and organelles. Here we show that a decline in the autophagy-lysosome system contributes to this as evidenced by a derangement in key autophagy markers in both mouse and human atherosclerotic plaques. By augmenting macrophage TFEB, the master transcriptional regulator of autophagy-lysosomal biogenesis, we can reverse the autophagy dysfunction of plaques, enhance aggrephagy of p62-enriched protein aggregates and blunt macrophage apoptosis and pro-inflammatory IL-1β levels, leading to reduced atherosclerosis. In order to harness this degradative response therapeutically, we also describe a natural sugar called trehalose as an inducer of macrophage autophagy-lysosomal biogenesis and show trehalose's ability to recapitulate the atheroprotective properties of macrophage TFEB overexpression. Our data support this practical method of enhancing the degradative capacity of macrophages as a therapy for atherosclerotic vascular disease