La capacidad de carga y la función arquitectónica en el mercado Caquetá del distrito de San Martín de Porres, 2020. Mercado mayorista de carnes ubicado en la zona Caquetá, perteneciente al sector 1 del distrito San Martín de Porres, 2020

La investigación tiene como objetivo principal, determinar la relación que existe entre la función arquitectónica y la capacidad de carga en el mercado Caquetá del sector 1 del distrito de San Martin de Porres, 2020. El tipo de estudio, es correlacional de enfoque cuantitativo. Se utilizó como instrumento de investigación, la encuesta, conformada por un total de 30 casos definidos como, usuarios que hacen compras en el mercado Caquetá. Para fundamentar la investigación, partimos de las siguientes teorías, donde se menciona que la capacidad de carga se refiere al número de personas que pueden ingresar en un edificio, refiriéndose al calculo que se hace de acuerdo a ley, denominado aforo, (CienFuentes, 1999). Por otro lado, la función arquitectónica es un término que se puede interpretar de distintas formas, partiendo de los conceptos básicos del diseño, resolviendo las necesidades del espacio y del usuario (Calduch, 2005). Se concluye que, el grado de relación es de: 0.871 determinando que existe correlación positiva muy fuerte entre las Variables, resultado obtenido de Rho Spearman, aprobando la hipótesis alternativa la cual señala que: El número de los usuarios influye en el uso de la infraestructura cambiando las funciones arquitectónicas del mercado Caquetá del Distrito San Martin de Porres, 2020

You Have the Right to Remain Silent: True Rights Statement Confessions

Panel summary: Have you ever had any questions or concerns about rights statements but didn’t know who to ask? Need to confess a rights statements blunder? Following the launch of RightsStatements.org, many DPLA Hubs have started discussions about standardizing rights statements for digital collections. This BOF session will bring together various experts from mid-Atlantic DPLA Hubs who have implemented standardized rights statements for digital collections, worked on education and training for its constituent institutions’ digital collections, or have done rights statements analyses across their home institution or constituent collections. The ultimate goal of the session will help build collective awareness and skills among digital collections managers or interested archivists for implementing standardized rights statements in an open and understanding space. Participants are welcome and encouraged to bring any and all rights statements for review, questions, or confessions. They can share tales of heartbreak, confusion, and woe and we will help troubleshoot and commiserate.MARAC Spring 2018 birds-of-a-feather panel on rights statements for digital collections

Creating a Collaborative Network to Promote Cultures of Academic Integrity in Manitoba’s Post-Secondary Institutions

In this article, we, as representatives from several post-secondary institutions across Manitoba and British Columbia, describe how sharing knowledge and experiences across institutions has informed and enhanced academic integrity initiatives at our respective institutions. We outline how participation in provincial, national, and international teaching and learning events as a collective has informed our work in academic integrity and led to the emergence of the Manitoba Academic Integrity Network (MAIN) in May 2019. We discuss the benefits of collaborating within a provincial network and next steps for expanding the reach of the network across institutions by engaging faculty, staff, and students

Ordered Porous Gold Electrodes to Enhance the Sensitivity of Enzyme-Based Glucose Sensors

Glucose sensors are essential tools for diabetes patients to use in monitoring their blood glucose levels. However, to be able to detect glucose in non-invasively collected physiological fluids, such as tears and urine, the sensitivity of these glucose sensors must be significantly higher than sensors that are currently used to detect glucose concentrations in blood. Increasing the specific surface area of enzyme-based glucose sensors through the use of ordered porous gold electrodes has been shown to enhance the sensitivity of these sensors. The enzyme-based ordered porous gold glucose sensor was demonstrated to be suitable in detecting glucose concentrations ranges that are similar to those occurring in tears. Although sensitivity of the glucose sensor is enhanced, the saturation threshold of the sensor is lowered. Further optimizations of the porous gold electrodes are required to eliminate signal saturation of these improved sensors

Prospectus, August 1988

https://spark.parkland.edu/prospectus_1988/1000/thumbnail.jp

The targeted delivery of multicomponent cargos to cancer cells by nanoporous particle-supported lipid bilayers.

Encapsulation of drugs within nanocarriers that selectively target malignant cells promises to mitigate side effects of conventional chemotherapy and to enable delivery of the unique drug combinations needed for personalized medicine. To realize this potential, however, targeted nanocarriers must simultaneously overcome multiple challenges, including specificity, stability and a high capacity for disparate cargos. Here we report porous nanoparticle-supported lipid bilayers (protocells) that synergistically combine properties of liposomes and nanoporous particles. Protocells modified with a targeting peptide that binds to human hepatocellular carcinoma exhibit a 10,000-fold greater affinity for human hepatocellular carcinoma than for hepatocytes, endothelial cells or immune cells. Furthermore, protocells can be loaded with combinations of therapeutic (drugs, small interfering RNA and toxins) and diagnostic (quantum dots) agents and modified to promote endosomal escape and nuclear accumulation of selected cargos. The enormous capacity of the high-surface-area nanoporous core combined with the enhanced targeting efficacy enabled by the fluid supported lipid bilayer enable a single protocell loaded with a drug cocktail to kill a drug-resistant human hepatocellular carcinoma cell, representing a 10(6)-fold improvement over comparable liposomes

Platinum Ordered Porous Electrodes: Developing a Platform for Fundamental Electrochemical Characterization

High surface area platinum electrodes with an ordered porous structure (Pt-OP electrodes) have been prepared and characterized by electrochemical methods. This study builds a foundation upon which we can seek an in-depth understanding of the limitations and design considerations to make efficient and stable Pt-OP electrodes for use in electrochemical applications. A set of Pt-OP electrodes were prepared by controlled electrodeposition of Pt through a self-assembled array of spherical particles and subsequent removal of the spherical templates by solvent extraction. The preparation method was shown to be reproducible and the resulting electrodes were found to have clean Pt surfaces and a large electrochemical surface area (A ecsa) resulting from both the porous structure, as well as the nano- and micro-scale surface roughness. Additionally, the Pt-OP electrodes exhibit a surface area enhancement comparable to commercially available electrocatalysts. In summary, the Pt-OP electrodes prepared herein show properties of interest for both gaining fundamental insights into electrocatalytic processes and for use in applications that would benefit from enhanced electrochemical response

Self-Assembly of Nanoparticles onto the Surfaces of Polystyrene Spheres with a Tunable Composition and Loading

Functional colloidal materials were prepared by design through the self-assembly of nanoparticles (NPs) on the surfaces of polystyrene (PS) spheres with control over NP surface coverage, NP-to-NP spacing, and NP composition. The ability to control and fine tune the coating was extended to the first demonstration of the co-assembly of NPs of dissimilar composition onto the same PS sphere, forming a multi-component coating. A broad range of NP decorated PS (PS@NPs) spheres were prepared with uniform coatings attributed to electrostatic and hydrogen bonding interactions between stabilizing groups on the NPs and the functionalized surfaces of the PS spheres. This versatile two-step method provides more fine control than methods previously demonstrated in the literature. These decorated PS spheres are of interest for a number of applications, such as catalytic reactions where the PS spheres provide a support for the dispersion, stabilization, and recovery of NP catalysts. The catalytic properties of these PS@NPs spheres were assessed by studying the catalytic degradation of azo dyes, an environmental contaminant detrimental to eye health. The PS@NPs spheres were used in multiple, sequential catalytic reactions while largely retaining the NP coating

Template Assisted Preparation of High Surface Area Macroporous Supports with Uniform and Tunable Nanocrystal Loadings

The incorporation of catalytic nanocrystals into macroporous support materials has been very attractive due to their increased catalyst mass activity. This increase in catalytic efficiency is attributed in part to the increased surface area to volume ratio of the catalysts and the use of complementary support materials that can enhance their catalytic activity and stability. A uniform and tunable coating of nanocrystals on porous matrices can be difficult to achieve with some techniques such as electrodeposition. More sophisticated techniques for preparing uniform nanocrystal coatings include atomic layer deposition, but it can be difficult to reproduce these processes at commercial scales required for preparing catalyst materials. In this study, catalytic nanocrystals supported on three dimensional (3D) porous structures were prepared. The demonstrated technique utilized scalable approaches for achieving a uniform surface coverage of catalysts through the use of polymeric sacrificial templates. This template assisted technique was demonstrated with a good control over the surface coverage of catalysts, support material composition, and porosities of the support material. A series of regular porous supports were each prepared with a uniform coating of nanocrystals, such as NaYF4 nanocrystals supported by a porous 3D lattice of Ti1−xSixO2, Pt nanocrystals on a 3D porous support of TiO2, Pd nanocrystals on Ni nanobowls, and Pt nanocrystals on 3D assemblies of Au/TiO2 nanobowls. The template assisted preparation of high surface area macroporous supports could be further utilized for optimizing the use of catalytic materials in chemical, electrochemical, and photochemical reactions through increasing their catalytic efficiency and stability

Anorectic and aversive effects of GLP-1 receptor agonism are mediated by brainstem cholecystokinin neurons, and modulated by GIP receptor activation

This work was funded by an MRC Career Development Award (MR/ P009824/1 and MR/P009824/2) to GD’A, as well as an MRC grant to SML/GD’A (MR/T032669/1), a BBSRC grant to SML (BB/M001067/1), and an additional direct contribution from Eli Lilly. D.J.H. was sup- ported by MRC (MR/N00275X/1 and MR/S025618/1), Diabetes UK (17/ 0005681), and the European Research Council (ERC) under the Eu- ropean Union’s Horizon 2020 research and innovation programme (Starting Grant 715884 to D.J.H.). AC was supported for part of this project by a travel grant from the Italian Society of Pharmacology and a fellowship from the Veronesi Foundation (Italy).Peer reviewedPublisher PD