WILLINGNESS-TO-PAY FOR VALUE ADDED BRED HEIFER CHARACTERISTICS

Livestock Production/Industries,

Placed for Success: Which Teachers Benefit from High-Quality Student Teaching Placements?

In the present study we consider whether certain pre-service teachers (PSTs) particularly benefit from high-quality student teaching experiences. To conduct these analyses, we connect student teaching and K-12 workforce data for six educator preparation programs (EPPs) and assess whether placement school and cooperating teacher characteristics predict the effectiveness of early-career teachers. Results show that high-quality student teaching placements especially benefit PSTs with lower GPAs and narrow effectiveness gaps between teachers with lower versus higher GPAs. These findings call for closer partnerships between EPPs and school districts and suggest that EPPs may wish to prioritize placements for PSTs with lower GPAs

Polyubiquitin binding to ABIN1 is required to prevent autoimmunity

The protein ABIN1 possesses a polyubiquitin-binding domain homologous to that present in nuclear factor kappa B (NF-kappa B) essential modulator (NEMO), a component of the inhibitor of NF-kappa B (I kappa B) kinase (IKK) complex. To address the physiological significance of polyubiquitin binding, we generated knockin mice expressing the ABIN1[D485N] mutant instead of the wild-type (WT) protein. These mice developed all the hallmarks of autoimmunity, including spontaneous formation of germinal centers, isotype switching, and production of autoreactive antibodies. Autoimmunity was suppressed by crossing to MyD88(-/-) mice, demonstrating that toll-like receptor (TLR)-MyD88 signaling pathways are needed for the phenotype to develop. The B cells and myeloid cells of the ABIN1[D485N] mice showed enhanced activation of the protein kinases TAK, IKK-alpha/beta, c-Jun N-terminal kinases, and p38 alpha mitogen-activated protein kinase and produced more IL-6 and IL-12 than WT. The mutant B cells also proliferated more rapidly in response to TLR ligands. Our results indicate that the interaction of ABIN1 with polyubiquitin is required to limit the activation of TLR-MyD88 pathways and prevent autoimmunity

Physiological stress response, reflex impairment and delayed mortality of white sturgeon Acipenser transmontanus exposed to simulated fisheries stressors

White sturgeon (Acipenser transmontanus) are the largest freshwater fish in North America and a species exposed to widespread fishing pressure. Despite the growing interest in recreational fishing for white sturgeon, little is known about the sublethal and lethal impacts of angling on released sturgeon. In summer (July 2014, mean water temperature 15.3°C) and winter (February 2015, mean water temperature 6.6°C), captive white sturgeon (n = 48) were exposed to a combination of exercise and air exposure as a method of simulating an angling event. After the stressor, sturgeon were assessed for a physiological stress response, and reflex impairments were quantified to determine overall fish vitality (i.e. capacity for survival). A physiological stress response occurred in all sturgeon exposed to a fishing-related stressor, with the magnitude of the res

Applicability of precision medicine approaches to managing hypertension in rural populations

As part of the Heart Healthy Lenoir Project, we developed a practice level intervention to improve blood pressure control. The goal of this study was: (i) to determine if single nucleotide polymorphisms (SNPs) that associate with blood pressure variation, identified in large studies, are applicable to blood pressure control in subjects from a rural population; (ii) to measure the association of these SNPs with subjects’ responsiveness to the hypertension intervention; and (iii) to identify other SNPs that may help understand patient-specific responses to an intervention. We used a combination of candidate SNPs and genome-wide analyses to test associations with either baseline systolic blood pressure (SBP) or change in systolic blood pressure one year after the intervention in two genetically defined ancestral groups: African Americans (AA) and Caucasian Americans (CAU). Of the 48 candidate SNPs, 13 SNPs associated with baseline SBP in our study; however, one candidate SNP, rs592582, also associated with a change in SBP after one year. Using our study data, we identified 4 and 15 additional loci that associated with a change in SBP in the AA and CAU groups, respectively. Our analysis of gene-age interactions identified genotypes associated with SBP improvement within different age groups of our populations. Moreover, our integrative analysis identified AQP4-AS1 and PADI2 as genes whose expression levels may contribute to the pleiotropy of complex traits involved in cardiovascular health and blood pressure regulation in response to an intervention targeting hypertension. In conclusion, the identification of SNPs associated with the success of a hypertension treatment intervention suggests that genetic factors in combination with age may contribute to an individual’s success in lowering SBP. If these findings prove to be applicable to other populations, the use of this genetic variation in making patient-specific interventions may help providers with making decisions to improve patient outcomes. Further investigation is required to determine the role of this genetic variance with respect to the management of hypertension such that more precise treatment recommendations may be made in the future as part of personalized medicine

Diabetic gastroparesis: Therapeutic options

Gastroparesis is a condition characterized by delayed gastric emptying and the most common known underlying cause is diabetes mellitus. Symptoms include nausea, vomiting, abdominal fullness, and early satiety, which impact to varying degrees on the patient’s quality of life. Symptoms and deficits do not necessarily relate to each other, hence despite significant abnormalities in gastric emptying, some individuals have only minimal symptoms and, conversely, severe symptoms do not always relate to measures of gastric emptying. Prokinetic agents such as metoclopramide, domperidone, and erythromycin enhance gastric motility and have remained the mainstay of treatment for several decades, despite unwanted side effects and numerous drug interactions. Mechanical therapies such as endoscopic pyloric botulinum toxin injection, gastric electrical stimulation, and gastrostomy or jejunostomy are used in intractable diabetic gastroparesis (DG), refractory to prokinetic therapies. Mitemcinal and TZP-101 are novel investigational motilin receptor and ghrelin agonists, respectively, and show promise in the treatment of DG. The aim of this review is to provide an update on prokinetic and mechanical therapies in the treatment of DG

Diving into the vertical dimension of elasmobranch movement ecology

Knowledge of the three-dimensional movement patterns of elasmobranchs is vital to understand their ecological roles and exposure to anthropogenic pressures. To date, comparative studies among species at global scales have mostly focused on horizontal movements. Our study addresses the knowledge gap of vertical movements by compiling the first global synthesis of vertical habitat use by elasmobranchs from data obtained by deployment of 989 biotelemetry tags on 38 elasmobranch species. Elasmobranchs displayed high intra- and interspecific variability in vertical movement patterns. Substantial vertical overlap was observed for many epipelagic elasmobranchs, indicating an increased likelihood to display spatial overlap, biologically interact, and share similar risk to anthropogenic threats that vary on a vertical gradient. We highlight the critical next steps toward incorporating vertical movement into global management and monitoring strategies for elasmobranchs, emphasizing the need to address geographic and taxonomic biases in deployments and to concurrently consider both horizontal and vertical movements

Assessing and treating three to twelve-year-olds displaying disruptive behaviour problems

The aim of this thesis was (a) to examine a Swedish version of a measure for early identification and treatment evaluation of children with disruptive behaviour problems and (b) to explore the effectiveness, in terms of reduction of children’s disruptive behavioural problems, of interventions not specifically directed towards the children but to their caregivers and other adults in their immediate environment. The focus of this thesis has been on clinical applicability. However, their have been considerable advances in the knowledge of the origins, development and maintenance of disruptive behaviour in children. This has led to corresponding changes in treatment. In line with this, research on phenomenology, prevalence, etiology, treatment and assessment of children that display disruptive behaviour are presented as an introduction to the empirical studies. The aim of study I was to develop and examine a systemic school-based model for detection and early intervention among 4 to 12 year old children who displayed externalizing behaviour problems. The intervention was a combination of the Marte Meo model and Coordination meetings. Treatment effects in the group who had received the intervention (N= 33) were compared with a group (N=16) who had received treatment-as-usual in their ordinary school setting. Assessments were carried out before and two years after the intervention. There was a significant decrease in children’s symptoms for the intervention group, but not for the comparison group. The aim of study II was to evaluate the effectiveness of the structured parent training programme Incredible Years Series in diverse clinical settings in Sweden. Parents of 113 children aged 3 to 9 participated in the study. Pre-data were collected prior to commencement of the parent training groups and post-data immediately after the training group sessions had finished. Significant reduction was found on all symptom-related measures in parents’ ratings. A significant increase in the self-rated well-being of the parents was also found. The aim of study III was to examine the psychometric properties and obtain Swedish norms for the Eyberg Child Behaviour Inventory (ECBI). Parents of 841 children aged 3 to 10 participated. The ECBI showed sound psychometric properties and seems to be a very useful measure in a Swedish context. Normative data from the Swedish sample was also presented. The aim of Study IV was to examine a three factor solution of the ECBI in a confirmatory factor analysis based on 22 items in a Swedish sample. The same sample as in study III was used. The results were consistent with the results from an American sample indicating that the 22-item version of the ECBI is a robust and useful alternative that can be used for evaluating and measuring treatment outcome. Preliminary normative data was also presented. Key words: Disruptive Behaviour Problems, Assessment, Early intervention, Eyberg Child Behaviour Inventory (ECBI), School based model, Marte Meo, Parent training, Incredible Years Serie