S1 stanica, rijeka Po: rukovanje podacima i prikaz podataka

The technical setting of the mete-oceanographic buoy at site S1 south of the Po River delta is presented. The station was deployed by Istituto di Scienze Marine (ISMAR) of CNR of Bologna, in cooperation with the local Regional Government and Environmental Agencies (ARPA) of E. Romagna, and ADRICOSM. The buoy mooring and data flow architecture is discussed, with some emphasis on the WWW data presentation. The possible integration with other remote stations, data and mete-oceanographic operational activities is also proposed.U radu je predstavljen tehnički postav meteorološko-oceanografske plutače na položaju S1 južno od delte rijeke Po. Stanicu su postavili ISMAR CNR iz Bolonje, u suradnji s lokalnom agencijom za zaštitu okoliša (ARPA) iz pokrajine Emilia-Romagna i ADRICOSM-om. Diskutirana su sama struktura plutače i arhitektura tijeka podataka s naglaskom na prikaz podataka na web-u. Predložena je, također, i moguća integracija s ostalim postajama, izvorima podataka i ostalim operativnim meteorološko-oceanografskim aktivnostima

Bioprofiling TS/A Murine Mammary Cancer for a Functional Precision Experimental Model

The TS/A cell line was established in 1983 from a spontaneous mammary tumor arisen in an inbred BALB/c female mouse. Its features (heterogeneity, low immunogenicity and metastatic ability) rendered the TS/A cell line suitable as a preclinical model for studies on tumor-host interactions and for gene therapy approaches. The integrated biological profile of TS/A resulting from the review of the literature could be a path towards the description of a precision experimental model of mammary cancer

Natural Versus Anthropic Influence on North Adriatic Coast Detected by Geochemical Analyses

This study focused on the geochemical and sedimentological characterization of recent sediments from two marine sites (S1 and E1) located in the North Adriatic Sea, between the Po River prodelta and the Rimini coast. Major and trace metal concentrations reflect the drainage area of the Po River and its tributaries, considered one of the most polluted areas in Europe. Sediment geochemistry of the two investigated sites denote distinct catchment areas. High values of Cr, Ni, Pb and Zn detected in sediments collected in the Po River prodelta (S1 site) suggest the Po River supply, while lower levels of these elements characterize sediments collected in front of the Rimini coast (E1 site), an indication of Northern Apennines provenance. Historical trends of Pb and Zn reconstructed from the sedimentary record around the E1 site document several changes that can be correlated with the industrialization subsequent to World War II, the implementation of the environmental policy in 1976 and the effects of the Comacchio dumping at the end of 1980. At the S1 site, the down core distributions of trace elements indicate a reduction of contaminants due to the introduction of the Italian Law 319/76 and the implementation of anti-pollution policies on automotive Pb (unleaded fuels) in the second half of the 1980s

AN ANALYTIC NETWORK MODEL FOR SMART CITIES

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Physical Volcanology and Facies Analysis of Silicic Lavas: Monte Amiata Volcano (Italy)

Monte Amiata (Italy) is a middle Pleistocene silicic volcano characterized by the extrusion of extensive (5–8 km long and 60 m thick on average) sheet-like lava flows (SLLFs). It is one of the prime volcanoes that have been involved in the volcanological debate on the genetic interpretation of large silicic flows. We performed integrated stratigraphic, volcanological, and structural field survey and petrochemical study of Monte Amiata SLLFs to describe their volcanic facies characteristics and to elucidate their eruptive and emplacement processes. Individual flow units exhibit basal autoclastic breccia beds or shear zones, frontal ramp structures, massive cores with subvertical cooling columnar jointing, coherent non-vesicular upper parts, and plain surfaces with pressure ridges. Internal shear-bedding and crystals and vesicles lineations define planar to twisted and straightened outflow layering. The absence of fragmental textures, both at micro- and macro-scale, supports the effusive nature for the SLLFs. The most common lithology is a vitrophyric trachydacite of whitish to light-gray color, showing a homogeneous porphyritic texture of K-feldspar, plagioclase, pyroxene, and biotite, in a glassy perlitic or microcrystalline poorly vesicular groundmass. Morphological features, facies characteristics, internal structure, and petrographic textures of these silicic sheet-like and long-lasting flows suggest that their effusive emplacement was governed by peculiar physicochemical and structural conditions

Pancreatic cancer spheres are more than just aggregates of stem marker-positive cells

Pancreatic cancer stem-like cells are described by membrane expression of CD24, CD44 and ESA (epithelial-specific antigen) and their capacity to grow as spheres in a serum-free medium containing well-defined growth factors. The capacity of a panel of four pancreatic cancer cell lines (PANC-1, CFPAC-1, PancTu-1 and PSN-1) to form spheres was tested. All cell lines with the exception of PancTu-1 developed spheres. Phenotypically, the sphere-growing cells showed an increased in vitro invasion capability. Both gene and protein expressions of markers of metastases [CXCR4 (CXC chemokine receptor 4), OPN (osteopontin) and CD44v6] and components of active hedgehog pathway signalling were assessed. Spheres clearly demonstrated increased expression of the above-mentioned markers when compared with their adherent counterpart. With the aim of identifying a minimum set of markers able to separate cells that have the capacity to form spheres from those incapable of forming spheres, a PCA (principal component analysis) of the multidimensional dataset was performed. Although PCA of the ‘accepted’ stemness genes was unable to separate sphere-forming from sphere-incapable cell lines, the addition of the ‘aggressiveness’ marker CD44v6 allowed a clear differentiation. Moreover, inoculation of the spheres and the adherent cells in vivo confirmed the superior aggressiveness (proliferation and metastasis) of the spheres over the adherent cells. In conclusion, the present study suggests that the sphere-growing cell population is not only composed of cells displaying classical stem membrane markers but also needs CD44v6-positive cells to successfully form spheres. Our results also emphasize the potential therapeutic importance of pathways such as CXCR4 and hedgehog for pancreatic cancer treatment