1,792 research outputs found
Far Ultraviolet Observations of the Dwarf Nova VW Hyi in Quiescence
We present a 904-1183 A spectrum of the dwarf nova VW Hydri taken with the
Far Ultraviolet Spectroscopic Explorer during quiescence, eleven days after a
normal outburst, when the underlying white dwarf accreter is clearly exposed in
the far ultraviolet. However, model fitting show that a uniform temperature
white dwarf does not reproduce the overall spectrum, especially at the shortest
wavelengths. A better approximation to the spectrum is obtained with a model
consisting of a white dwarf and a rapidly rotating ``accretion belt''. The
white dwarf component accounts for 83% of the total flux, has a temperature of
23,000K, a v sin i = 400 km/s, and a low carbon abundance. The best-fit
accretion belt component accounts for 17% of the total flux, has a temperature
of about 48,000-50,000K, and a rotation rate Vrot sin i around 3,000-4,000
km/s. The requirement of two components in the modeling of the spectrum of VW
Hyi in quiescence helps to resolve some of the differences in interpretation of
ultraviolet spectra of VW Hyi in quiescence. However, the physical existence of
a second component (and its exact nature) in VW Hyi itself is still relatively
uncertain, given the lack of better models for spectra of the inner disk in a
quiescent dwarf nova.Comment: 6 figures, 10 printed page in the journal, to appear in APJ, 1 Sept.
2004 issue, vol. 61
Genetic study of congenital bile-duct dilatation identifies de novo and inherited variants in functionally related genes
Background:
Congenital dilatation of the bile-duct (CDD) is a rare, mostly sporadic, disorder that results in bile retention with severe associated complications. CDD affects mainly Asians. To our knowledge, no genetic study has ever been conducted.
Methods:
We aim to identify genetic risk factors by a “trio-based” exome-sequencing approach, whereby 31 CDD probands and their unaffected parents were exome-sequenced. Seven-hundred controls from the local population were used to detect gene-sets significantly enriched with rare variants in CDD patients.
Results:
Twenty-one predicted damaging de novo variants (DNVs; 4 protein truncating and 17 missense) were identified in several evolutionarily constrained genes (p < 0.01). Six genes carrying DNVs were associated with human developmental disorders involving epithelial, connective or bone morphologies (PXDN, RTEL1, ANKRD11, MAP2K1, CYLD, ACAN) and four linked with cholangio- and hepatocellular carcinomas (PIK3CA, TLN1 CYLD, MAP2K1). Importantly, CDD patients have an excess of DNVs in cancer-related genes (p < 0.025). Thirteen genes were recurrently mutated at different sites, forming compound heterozygotes or functionally related complexes within patients.
Conclusions:
Our data supports a strong genetic basis for CDD and show that CDD is not only genetically heterogeneous but also non-monogenic, requiring mutations in more than one genes for the disease to develop. The data is consistent with the rarity and sporadic presentation of CDD
The Tevatron at the Frontier of Dark Matter Direct Detection
Direct detection of dark matter (DM) requires an interaction of dark matter
particles with nucleons. The same interaction can lead to dark matter pair
production at a hadron collider, and with the addition of initial state
radiation this may lead to mono-jet signals. Mono-jet searches at the Tevatron
can thus place limits on DM direct detection rates. We study these bounds both
in the case where there is a contact interaction between DM and the standard
model and where there is a mediator kinematically accessible at the Tevatron.
We find that in many cases the Tevatron provides the current best limit,
particularly for light dark matter, below 5 GeV, and for spin dependent
interactions. Non-standard dark matter candidates are also constrained. The
introduction of a light mediator significantly weakens the collider bound. A
direct detection discovery that is in apparent conflict with mono-jet limits
will thus point to a new light state coupling the standard model to the dark
sector. Mono-jet searches with more luminosity and including the spectrum shape
in the analysis can improve the constraints on DM-nucleon scattering cross
section.Comment: 20 pages, 8 figures, final version in JHE
Quasiparticle interfacial level alignment of highly hybridized frontier levels: HO on TiO(110)
Knowledge of the frontier levels' alignment prior to photo-irradiation is
necessary to achieve a complete quantitative description of HO
photocatalysis on TiO(110). Although HO on rutile TiO(110) has been
thoroughly studied both experimentally and theoretically, a quantitative value
for the energy of the highest HO occupied levels is still lacking. For
experiment, this is due to the HO levels being obscured by hybridization
with TiO(110) levels in the difference spectra obtained via ultraviolet
photoemission spectroscopy (UPS). For theory, this is due to inherent
difficulties in properly describing many-body effects at the
HO-TiO(110) interface. Using the projected density of states (DOS) from
state-of-the-art quasiparticle (QP) , we disentangle the adsorbate and
surface contributions to the complex UPS spectra of HO on TiO(110). We
perform this separation as a function of HO coverage and dissociation on
stoichiometric and reduced surfaces. Due to hybridization with the TiO(110)
surface, the HO 3a and 1b levels are broadened into several peaks
between 5 and 1 eV below the TiO(110) valence band maximum (VBM). These
peaks have both intermolecular and interfacial bonding and antibonding
character. We find the highest occupied levels of HO adsorbed intact and
dissociated on stoichiometric TiO(110) are 1.1 and 0.9 eV below the VBM. We
also find a similar energy of 1.1 eV for the highest occupied levels of HO
when adsorbed dissociatively on a bridging O vacancy of the reduced surface. In
both cases, these energies are significantly higher (by 0.6 to 2.6 eV) than
those estimated from UPS difference spectra, which are inconclusive in this
energy region. Finally, we apply self-consistent QP (scQP1) to obtain
the ionization potential of the HO-TiO(110) interface.Comment: 12 pages, 12 figures, 1 tabl
Organization of Block Copolymers using NanoImprint Lithography: Comparison of Theory and Experiments
We present NanoImprint lithography experiments and modeling of thin films of
block copolymers (BCP). The NanoImprint lithography is used to align
perpendicularly lamellar phases, over distances much larger than the natural
lamellar periodicity. The modeling relies on self-consistent field calculations
done in two- and three-dimensions. We get a good agreement with the NanoImprint
lithography setups. We find that, at thermodynamical equilibrium, the ordered
BCP lamellae are much better aligned than when the films are deposited on
uniform planar surfaces
Rewritable nanoscale oxide photodetector
Nanophotonic devices seek to generate, guide, and/or detect light using
structures whose nanoscale dimensions are closely tied to their functionality.
Semiconducting nanowires, grown with tailored optoelectronic properties, have
been successfully placed into devices for a variety of applications. However,
the integration of photonic nanostructures with electronic circuitry has always
been one of the most challenging aspects of device development. Here we report
the development of rewritable nanoscale photodetectors created at the interface
between LaAlO3 and SrTiO3. Nanowire junctions with characteristic dimensions
2-3 nm are created using a reversible AFM writing technique. These nanoscale
devices exhibit a remarkably high gain for their size, in part because of the
large electric fields produced in the gap region. The photoconductive response
is gate-tunable and spans the visible-to-near-infrared regime. The ability to
integrate rewritable nanoscale photodetectors with nanowires and transistors in
a single materials platform foreshadows new families of integrated
optoelectronic devices and applications.Comment: 5 pages, 5 figures. Supplementary Information 7 pages, 9 figure
Nationwide Genomic Study in Denmark Reveals Remarkable Population Homogeneity
Denmark has played a substantial role in the history of Northern Europe. Through a nationwide scientific outreach initiative, we collected genetic and anthropometrical data from ∼800 high school students and used them to elucidate the genetic makeup of the Danish population, as well as to assess polygenic predictions of phenotypic traits in adolescents. We observed remarkable homogeneity across different geographic regions, although we could still detect weak signals of genetic structure reflecting the history of the country. Denmark presented genomic affinity with primarily neighboring countries with overall resemblance of decreasing weight from Britain, Sweden, Norway, Germany, and France. A Polish admixture signal was detected in Zealand and Funen, and our date estimates coincided with historical evidence of Wend settlements in the south of Denmark. We also observed considerably diverse demographic histories among Scandinavian countries, with Denmark having the smallest current effective population size compared to Norway and Sweden. Finally, we found that polygenic prediction of self-reported adolescent height in the population was remarkably accurate (R2 = 0.639 ± 0.015). The high homogeneity of the Danish population could render population structure a lesser concern for the upcoming large-scale gene-mapping studies in the country
Advances in IVUS/OCT and Future Clinical Perspective of Novel Hybrid Catheter System in Coronary Imaging
Intravascular ultrasound (IVUS) and optical coherence tomography (OCT) have been
developed and improved as both diagnostic and guidance tools for interventional
procedures over the past three decades. IVUS has a resolution of 100µm with a
high tissue penetration and capability of assessing the entire structure of a coronary
artery including the external elastic membrane, whereas OCT has a higher resolution of
10–20µm to assess endoluminal structures with a limited tissue penetration compared
to IVUS. Recently, two companies, CONAVI and TERUMO, integrated IVUS and OCT into
a single catheter system. With their inherent strength and limitations, the combined IVUS
and OCT probes are complementary and work synergistically to enable a comprehensive
depiction of coronary artery. In this review, we summarize the performance of the two
intracoronary imaging modalit
MicroRNAs in pulmonary arterial remodeling
Pulmonary arterial remodeling is a presently irreversible pathologic hallmark of pulmonary arterial hypertension (PAH). This complex disease involves pathogenic dysregulation of all cell types within the small pulmonary arteries contributing to vascular remodeling leading to intimal lesions, resulting in elevated pulmonary vascular resistance and right heart dysfunction. Mutations within the bone morphogenetic protein receptor 2 gene, leading to dysregulated proliferation of pulmonary artery smooth muscle cells, have been identified as being responsible for heritable PAH. Indeed, the disease is characterized by excessive cellular proliferation and resistance to apoptosis of smooth muscle and endothelial cells. Significant gene dysregulation at the transcriptional and signaling level has been identified. MicroRNAs are small non-coding RNA molecules that negatively regulate gene expression and have the ability to target numerous genes, therefore potentially controlling a host of gene regulatory and signaling pathways. The major role of miRNAs in pulmonary arterial remodeling is still relatively unknown although research data is emerging apace. Modulation of miRNAs represents a possible therapeutic target for altering the remodeling phenotype in the pulmonary vasculature. This review will focus on the role of miRNAs in regulating smooth muscle and endothelial cell phenotypes and their influence on pulmonary remodeling in the setting of PAH
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