11 research outputs found
Intercellular Adhesion Molecule-5 Induces Dendritic Outgrowth by Homophilic Adhesion
Intercellular adhesion molecule-5 (ICAM-5)
is a dendritically polarized membrane glycoprotein in telencephalic neurons, which shows heterophilic binding to leukocyte
b2-integrins. Here, we show that the human ICAM-5 protein interacts in a homophilic manner through the binding of the immunoglobulin domain 1 to domains 4â5. Surface coated ICAM-5-Fc promoted
dendritic outgrowth and arborization of ICAM-
5âexpressing hippocampal neurons. During dendritogenesis in developing rat brain, ICAM-5 was in monomer form, whereas in mature neurons it migrated as a high molecular weight complex. The findings indicate
that its homophilic binding activity was regulated by nonmonomer/monomer transition. Thus, ICAM-5 displays two types of adhesion activity, homophilic binding between neurons and heterophilic binding between neurons and leukocytes