DISCUS - The Deep Interior Scanning CubeSat mission to a rubble pile near-Earth asteroid

We have performed an initial stage conceptual design study for the Deep Interior Scanning CubeSat (DISCUS), a tandem 6U CubeSat carrying a bistatic radar as main payload. DISCUS will be operated either as an independent mission or accompanying a larger one. It is designed to determine the internal macroporosity of a 260-600 m diameter Near Earth Asteroid (NEA) from a few kilometers distance. The main goal will be to achieve a global penetration with a low-frequency signal as well as to analyze the scattering strength for various different penetration depths and measurement positions. Moreover, the measurements will be inverted through a computed radar tomography (CRT) approach. The scientific data provided by DISCUS would bring more knowledge of the internal configuration of rubble pile asteroids and their collisional evolution in the Solar System. It would also advance the design of future asteroid deflection concepts. We aim at a single-unit (1U) radar design equipped with a half-wavelength dipole antenna. The radar will utilize a stepped-frequency modulation technique the baseline of which was developed for ESA's technology projects GINGER and PIRA. The radar measurements will be used for CRT and shape reconstruction. The CubeSat will also be equipped with an optical camera system and laser altimeter to sup- port navigation and shape reconstruction. We provide the details of the measurement methods to be applied along with the requirements derived of the known characteristics of rubble pile asteroids.Comment: Submitted to Advances in Space Researc

Famine as the Outcome of Political Production and Market Failures

Summary Famines are not explainable as short?term crisis events; they are more a function of long?term trends resulting from a failure of policy to deal appropriately with demographic, environmental, productivity, and political pressures, all of which make segments of society and regions highly vulnerable to exogenous shocks. Optimal strategies for famine prevention must, therefore, build on a recognition that institutions and their policies play a key role, and that long?term forces are as relevant as short?term factors. An end to armed conflict will go far to prevent famine in Africa, but without sustainable economic growth, supported by well?designed public action and improved private participation, the risk of famine will persist. Resumé La Famine Comme Résultat De L'Échec De La Politique, De La Production Et Du Marché L'on ne saurait expliquer les famines en tant qu'événements qui se produisent dans des crises à court terme; elles sont plutôt le résultat de tendances séculaires à plus long terme qui découlent d'un manquement de la politique à s'adresser de manière appropriée aux pressions démographiques, environnementales, productives et politiques: lesquelles pressions rendent certains secteurs de la société, et des régions, hautement vulnérables aux chocs exogènes. Toute stratégie optimale de lutte contre la famine doit donc se fonder sur la reconnaissance du fait que les institutions et leurs politiques jouent un rôle crucial, et que les forces agissant à long terme sont tout aussi pertinentes que les facteurs à échéance plus corte. Une cessation du combat armé contribuerait d'une manière très décisive à la lutte contre la famine en Afrique; or, dans l'absence d'une croissance économique sou tenable ayant à son appui une action publique judicieusement planifiée et une participation meilleure du secteur privé, les risques de la famine vont persister. Resumen El Hambre Como Resultado De Fracasos Políticos, Productivos Y Mercantiles El hambre no puede explicarse como una serie de situaciones críticas a corto plazo; mas bien es una función de tendencias establecidas que a largo plazo son el resultado de fracasos de los programas de acción al confrontar presiones demográficas, ambientales, de productividad y políticas; todos estos factores hacen que ciertos segmentos de la sociedad y de las regiones sean altamente vulnerables a choques externos. Por lo tanto, las estrategias óptimas para la prevención del hambre deberían edificar sobre el reconocimiento de que las instituciones y sus programas juegan un papel vital, y de que las fuerzas a largo plazo son tan pertinentes como los factores a corto plazo. El fin de los conflictos armados contribuiría en gran medida a la prevención del hambre en el Africa, pero sin un crecimiemto económico sostenible, apoyado por una acción pública bien planeada y mayor participación privada, el riesgo del hambre persistirá

Efficacy and safety of TDF/FTC-containing first-line HAART in clinical practice – 2-year data from the German Outpatient Cohort

Poster presentation: Purpose of the study First-line HAART with tenofovir DF (TDF) and FTC in pivotal trials has been associated with high efficacy and good tolerability. However, real-life clinical practice often differs from clinical trials due to co-morbidities, co-infections, and less intensive clinical monitoring. To evaluate efficacy and safety of first-line HAART in a day-to-day setting, this Gilead-sponsored non-interventional cohort was established. Methods Between July 2005 and August 2006, 533 HIV-1 infected antiretroviral-naïve patients from 50 German centres enrolled in this non-interventional cohort. All patients were followed every 3 months for 3 years to monitor efficacy (viral load [VL], CD4), tolerability, renal safety, regimen changes and resistance profile. All patients received TDF+FTC as a single tablet (Truvada, TVD) in combination with either an NNRTI or PI/r as their first antiretroviral regimen. Summary of results As of June 2008, 2 years of therapy have been documented for 330/533 (62%) patients. At treatment initiation, 81% were male; median age was 39 years; clinical AIDS diagnosis was documented in 22%; 47% started therapy with CD4 <200 cells/mm3. TVD was combined with an NNRTI (43%) or a PI/r (57%). After 24 months, in an As-Treated (AT) analysis, 85% patients achieved a VL <50 copies/ml (VL <500 copies/ml: 97%), median CD4 count increased from 217 at baseline to 450 cells/mm3 (IQR: 325–608). Truvada showed a good safety profile; 76 adverse events (AEs) of any grade were reported in 66/533 patients (12%); six of these were judged serious. Fourteen (2.6%) patients discontinued TVD due to AEs. Renal abnormalities of any grade were reported in 10 patients (1.9%). Virological failure was documented in nine patients, of which eight were genotyped; M184V/I was detected in three, K65R in two patients. Conclusion During 2 years of follow-up, the overall safety of TVD was good; renal AEs of any grade were reported in 1.9% of patients. K65R was detected in two patients. First-line HAART with TVD plus an NNRTI or PI/r in clinical practice showed comparable efficacy to that observed in controlled clinical trials

Neural correlates of finger gnosis

Neuropsychological studies have described patients with a selective impairment of finger identification in association with posterior parietal lesions. However, evidence of the role of these areas in finger gnosis from studies of the healthy human brain is still scarce. Here we used functional magnetic resonance imaging to identify the brain network engaged in a novel finger gnosis task, the intermanual in-between task (IIBT), in healthy participants. Several brain regions exhibited a stronger blood oxygenation level-dependent (BOLD) response in IIBT than in a control task that did not explicitly rely on finger gnosis but used identical stimuli and motor responses as the IIBT. The IIBT involved stronger signal in the left inferior parietal lobule (IPL), bilateral precuneus (PCN), bilateral premotor cortex, and left inferior frontal gyrus. In all regions, stimulation of nonhomologous fingers of the two hands elicited higher BOLD signal than stimulation of homologous fingers. Only in the left anteromedial IPL (a-mIPL) and left PCN did signal strength decrease parametrically from nonhomology, through partial homology, to total homology with stimulation delivered synchronously to the two hands. With asynchronous stimulation, the signal was stronger in the left a-mIPL than in any other region, possibly indicating retention of task-relevant information. We suggest that the left PCN may contribute a supporting visuospatial representation via its functional connection to the right PCN. The a-mIPL may instead provide the core substrate of an explicit bilateral body structure representation for the fingers that when disrupted can produce the typical symptoms of finger agnosia

The photosynthesis apparatus of European mistletoe (Viscum album)

European mistletoe (Viscum album) is known for its special mode of cellular respiration. It lacks the mitochondrial NADH dehydrogenase complex (Complex I of the respiratory chain) and has restricted capacities to generate mitochondrial adenosine triphosphate (ATP). Here, we present an investigation of the V. album energy metabolism taking place in chloroplasts. Thylakoids were purified from young V. album leaves, and membrane-bound protein complexes were characterized by Blue native polyacrylamide gel electrophoresis as well as by the complexome profiling approach. Proteins were systematically identified by label-free quantitative shotgun proteomics. We identified 41,800 distinct proteins (accessible at https://complexomemap.de/va_leaves), including nearly 100 proteins forming part of the protein complexes involved in the light-dependent part of photosynthesis. The photosynthesis apparatus of V. album has distinct features: (1) comparatively low amounts of Photosystem I; (2) absence of the NDH complex (the chloroplast pendant of mitochondrial Complex I involved in cyclic electron transport (CET) around Photosystem I); (3) reduced levels of the proton gradient regulation 5 (PGR5) and proton gradient regulation 5-like 1 (PGRL1) proteins, which offer an alternative route for CET around Photosystem I; (4) comparable amounts of Photosystem II and the chloroplast ATP synthase complex to other seed plants. Our data suggest a restricted capacity for chloroplast ATP biosynthesis by the photophosphorylation process. This is in addition to the limited ATP supply by the mitochondria. We propose a view on mistletoe’s mode of life, according to which its metabolism relies to a greater extent on energy-rich compounds provided by the host trees

A Half-Megasecond Chandra Observation of the Oxygen-Rich Supernova Remnant G292.0+1.8

We report on our initial analysis of a deep 510 ks observation of the Galactic oxygen-rich supernova remnant (SNR) G292.0+1.8 with the {\it Chandra X-ray Observatory}. Our new {\it Chandra} ACIS-I observation has a larger field of view and an order of magnitude deeper exposure than the previous {\it Chandra} observation, which allows us to cover the entire SNR and to detect new metal-rich ejecta features. We find a highly non-uniform distribution of thermodynamic conditions of the X-ray emitting hot gas that correlates well with the optical [O {\small III}] emission, suggesting the possibility that the originating supernova explosion of G292.0+1.8 was itself asymmetric. We also reveal spectacular substructures of a torus, a jet, and an extended central compact nebula all associated with the embedded pulsar J1124$-$5916.Comment: 10 pages including 1 table and 2 figures (both figures are color), accepted by ApJ Letter