Impactos da diversidade de informações sobre a pandemia de COVID-19 no conhecimento e comportamento populacional, no município de Araras – SP

No fim de 2019, em Wuhan, na China, foi descoberto um novo coronavírus causador da doença COVID-19. Depois, diversos casos da doença foram identificados pelo mundo e o vírus se espalhou, causando uma pandemia. Até hoje, faltam informações sobre essa patologia e seu vírus causador, principalmente quanto a seus tratamento e prevenção, levando à disseminação de pseudoinformações e de notícias equívocas sobre variados aspectos da COVID-19, o que favoreceu a prática de comportamentos de risco pela população. Conforme exposto acima, fez-se necessário analisar o quão grave foi o impacto da replicação descontrolada de informações ludibriosas sobre o novo coronavírus e sobre a COVID-19. Assim, foi realizada uma pesquisa aprofundada acerca dos danos causados na saúde pública pelo alastramento de tais notícias sendo a população da cidade de Araras escolhida para análise da dimensão dessas implicações por meio de entrevistas semi-estruturadas

Frequency of musculoskeletal pain and thermal comfort in students of dentistry

The objective of this study was to evaluate the frequency of musculoskeletal symptoms (MS) and thermal sensation in the clinical setting in dental students. We evaluated 124 students in the curricular stage. The frequency of MS was evaluated with the Nordic Musculoskeletal Questionnaire and the thermal sensation through reporting by scale ranging from very cold to very hot. About 80% of the students had some MS. The sites with the highest frequency were the regions of the thoracic spine (46%) and neck (45%) (P < 0.001). Neck pain was associated with thermal discomfort (P = 0.02), especially in women. Positive correlations were also observed between the different anatomical regions and intensity of the symptoms (P <0.05), mainly between the thoracic and lumbar spine (Rs = 0.53), knee and ankle/foot (Rs = 0.52), and neck and shoulder (Rs = 0.51) for both sexes. Regarding thermal sensation of the clinical environment, the clinical environment temperature was considered comfortable by 33.9% of the patients. MS are frequent in dentistry students, especially in the spinal region, and pain in the neck region is correlated with thermal sensation of cold, calling attention to the need for the prevention and for ergonomic and lifestyle changes

Chitosan-tripolyphosphate Nanoparticles As Arrabidaea Chica Standardized Extract Carrier: Synthesis, Characterization, Biocompatibility, And Antiulcerogenic Activity.

Natural products using plants have received considerable attention because of their potential to treat various diseases. Arrabidaea chica (Humb. & Bonpl.) B. Verlot is a native tropical American vine with healing properties employed in folk medicine for wound healing, inflammation, and gastrointestinal colic. Applying nanotechnology to plant extracts has revealed an advantageous strategy for herbal drugs considering the numerous features that nanostructured systems offer, including solubility, bioavailability, and pharmacological activity enhancement. The present study reports the preparation and characterization of chitosan-sodium tripolyphosphate nanoparticles (NPs) charged with A. chica standardized extract (AcE). Particle size and zeta potential were measured using a Zetasizer Nano ZS. The NP morphological characteristics were observed using scanning electron microscopy. Our studies indicated that the chitosan/sodium tripolyphosphate mass ratio of 5 and volume ratio of 10 were found to be the best condition to achieve the lowest NP sizes, with an average hydrodynamic diameter of 150±13 nm and a zeta potential of +45±2 mV. Particle size decreased with AcE addition (60±10.2 nm), suggesting an interaction between the extract's composition and polymers. The NP biocompatibility was evaluated using human skin fibroblasts. AcE-NP demonstrated capability of maintaining cell viability at the lowest concentrations tested, stimulating cell proliferation at higher concentrations. Antiulcerogenic activity of AcE-NP was also evaluated with an acute gastric ulcer experimental model induced by ethanol and indomethacin. NPs loaded with A. chica extract reduced the ulcerative lesion index using lower doses compared with the free extract, suggesting that extract encapsulation in chitosan NPs allowed for a dose reduction for a gastroprotective effect. The AcE encapsulation offers an approach for further application of the A. chica extract that could be considered a potential candidate for ulcer-healing pharmaceutical systems.103897-390

Chitosan-tripolyphosphate nanoparticles as arrabidaea chica standardized extract carrier: synthesis, characterization, biocompatibility, and antiulcerogenic activity

Natural products using plants have received considerable attention because of their potential to treat various diseases. Arrabidaea chica (Humb. & Bonpl.) B. Verlot is a native tropical American vine with healing properties employed in folk medicine for wound healing, inflammation, and gastrointestinal colic. Applying nanotechnology to plant extracts has revealed an advantageous strategy for herbal drugs considering the numerous features that nanostructured systems offer, including solubility, bioavailability, and pharmacological activity enhancement. The present study reports the preparation and characterization of chitosan-sodium tripolyphosphate nanoparticles (NPs) charged with A. chica standardized extract (AcE). Particle size and zeta potential were measured using a Zetasizer Nano ZS. The NP morphological characteristics were observed using scanning electron microscopy. Our studies indicated that the chitosan/sodium tripolyphosphate mass ratio of 5 and volume ratio of 10 were found to be the best condition to achieve the lowest NP sizes, with an average hydrodynamic diameter of 150 +/- 13 nm and a zeta potential of +45 +/- 2 mV. Particle size decreased with AcE addition (60 +/- 10.2 nm), suggesting an interaction between the extract's composition and polymers. The NP biocompatibility was evaluated using human skin fibroblasts. AcE-NP demonstrated capability of maintaining cell viability at the lowest concentrations tested, stimulating cell proliferation at higher concentrations. Antiulcerogenic activity of AcE-NP was also evaluated with an acute gastric ulcer experimental model induced by ethanol and indomethacin. NPs loaded with A. chica extract reduced the ulcerative lesion index using lower doses compared with the free extract, suggesting that extract encapsulation in chitosan NPs allowed for a dose reduction for a gastroprotective effect. The AcE encapsulation offers an approach for further application of the A. chica extract that could be considered a potential candidate for ulcer-healing pharmaceutical systems1038973909CONSELHO NACIONAL DE DESENVOLVIMENTO CIENTÍFICO E TECNOLÓGICO - CNPQFUNDAÇÃO DE AMPARO À PESQUISA DO ESTADO DE SÃO PAULO - FAPESPsem informação2009/16484-1; 2010/07781-0; 2009/51020-6; 2011/09127-

Liposomal lidocaine gel for topical use at the oral mucosa: characterization, in vitro assays and in vivo anesthetic efficacy in humans.

FAPESP - FUNDAÇÃO DE AMPARO À PESQUISA DO ESTADO DE SÃO PAULOTo characterize liposomal-lidocaine formulations for topical use on oral mucosa and to compare their in vitro permeation and in vivo anesthetic efficacy with commercially available lidocaine formulations. Large unilamellar liposomes (400 nm) containing lidocaine were prepared using phosphatidylcholine, cholesterol, and α-tocoferol (4:3:0.07, w:w:w) and were characterized in terms of membrane/water partition coefficient, encapsulation efficiency, size, polydispersity, zeta potential, and in vitro release. In vitro permeation across pig palatal mucosa and in vivo topical anesthetic efficacy on the palatal mucosa in healthy volunteers (double-blinded cross-over, placebo controlled study) were performed. The following formulations were tested: liposome-encapsulated 5% lidocaine (Liposome-Lido5); liposome-encapsulated 2.5% lidocaine (Liposome-Lido2.5); 5% lidocaine ointment (Xylocaina®), and eutectic mixture of lidocaine and prilocaine 2.5% (EMLA®). The Liposome-Lido5 and EMLA showed the best in vitro permeation parameters (flux and permeability coefficient) in comparison with Xylocaina and placebo groups, as well as the best in vivo topical anesthetic efficacy. We successfully developed and characterized a liposome encapsulated 5% lidocaine gel. It could be considered an option to other topical anesthetic agents for oral mucosa.To characterize liposomal-lidocaine formulations for topical use on oral mucosa and to compare their in vitro permeation and in vivo anesthetic efficacy with commercially available lidocaine formulations. Large unilamellar liposomes (400 nm) containing lidocaine were prepared using phosphatidylcholine, cholesterol, and α-tocoferol (4:3:0.07, w:w:w) and were characterized in terms of membrane/water partition coefficient, encapsulation efficiency, size, polydispersity, zeta potential, and in vitro release. In vitro permeation across pig palatal mucosa and in vivo topical anestheticefficacy on the palatal mucosa in healthy volunteers (double-blinded cross-over, placebo controlled study) were performed. The following formulations were tested: liposome-encapsulated 5% lidocaine (Liposome-Lido5); liposome-encapsulated 2.5% lidocaine (Liposome-Lido2.5); 5% lidocaine ointment (Xylocaina®), and eutectic mixture of lidocaine and prilocaine 2.5% (EMLA®). The Liposome-Lido5 and EMLA showed the best in vitro permeation parameters (flux and permeability coefficient) in comparison with Xylocaina and placebo groups, as well as the best in vivo topical anesthetic efficacy. We successfully developed and characterized a liposome encapsulated 5% lidocaine gel. It could be considered an option to other topical anesthetic agents for oral mucosa2511119FAPESP - FUNDAÇÃO DE AMPARO À PESQUISA DO ESTADO DE SÃO PAULOFAPESP - FUNDAÇÃO DE AMPARO À PESQUISA DO ESTADO DE SÃO PAULO2006/00121-9; 2007/05734-1; 2009/08860-

Pharmaceutical Compositions Comprising Arrabidaea Chica Extract In Controlled Release Systems, Production Process And Use Thereof

SISTEMA E MÉTODO DE FUMO ELÉTRICO. Um sistema de fumo elétrico (21) compreendendo um cigarro (23) e um acendedor elétrico (25), no qual o cigarro (23) compreende uma superfície fosca de tabaco tubular (66) parcialmente cheia com material de tabaco (80) de modo a definir uma porção de barra de tabaco cheia (60) e uma porção de barra de tabaco vaga (90). O cigarro (23) e o acendedor (25) são mutuamente dispostos de modo que quando o cigarro (23) é recebido no acendedor (25), o elemento do aquecedor elétrico (37) do acendedor (25) pelo menos parcialmente sobrepõe pelo menos uma porção da porção da barra de tabaco cheia (60). O cigarro (23) e o acendedor (25) são também mutuamente dispostos de modo que quando o cigarro (23) é recebido no acondedor (25), a extremidade livre (15) do cigarro (23) fica fechada. O cigarro (23) inclui uma zona de perfurações (12,14) em uma localização ao longo da porção da barra de tabaco cheia (60), com o cigarro sendo isento de perfurações ao longo da porção da barra de tabaco vaga (90).BRPI1105312 (A2)A61K36/185A61K9/127A61K9/50A61K9/51BR2011PI05312A61K36/185A61K9/127A61K9/50A61K9/5