Development of an activity disease score in patients with uveitis (UVEDAI)

To develop a disease activity index for patients with uveitis (UVEDAI) encompassing the relevant domains of disease activity considered important among experts in this field. The steps for designing UVEDAI were: (a) Defining the construct and establishing the domains through a formal judgment of experts, (b) A two-round Delphi study with a panel of 15 experts to determine the relevant items, (c) Selection of items: A logistic regression model was developed that set ocular inflammatory activity as the dependent variable. The construct "uveitis inflammatory activity" was defined as any intraocular inflammation that included external structures (cornea) in addition to uvea. Seven domains and 15 items were identified: best-corrected visual acuity, inflammation of the anterior chamber (anterior chamber cells, hypopyon, the presence of fibrin, active posterior keratic precipitates and iris nodules), intraocular pressure, inflammation of the vitreous cavity (vitreous haze, snowballs and snowbanks), central macular edema, inflammation of the posterior pole (the presence and number of choroidal/retinal lesions, vascular inflammation and papillitis), and global assessment from both (patient and physician). From all the variables studied in the multivariate model, anterior chamber cell grade, vitreous haze, central macular edema, inflammatory vessel sheathing, papillitis, choroidal/retinal lesions and patient evaluation were included in UVEDAI. UVEDAI is an index designed to assess the global ocular inflammatory activity in patients with uveitis. It might prove worthwhile to motorize the activity of this extraarticular manifestation of some rheumatic diseases

FATTY ACIDS, a-TOCOFEROL AND L-CARNITINE: THEIR RELATIONSHIPS IN TURBOT (Scophthalmus maxímus L. GROWTH: FIRST RESULTS.

The effect that the administration of diets rich in essential fattyacids has on growth in weight of turbot (S. maxímus), contrasted with non-enriched diets supplemented with a-tocoferol, and at two different levels of administration of l-carnitine has be en studied. The weight of individual s corresponding to the different levels of treatment is analysed using MANOVA of repeated measures, resulting in significant differences between the different treatments, with p<O.OOl. An evaluation is made of the efficiency of each of the different treatments with respect to growth and body content in fat and protein

The production of ammonia in mass cultures of the rotifer, Brachionus plicatilis O. F. Müller, feeding on bread yeast

The production of ammonia in mass cultures of the rotifer, B.plicatilis,fed with different concentrations of bread yeast and temperatures are compared w i th that of the rotifer initially inoculated with algae culture.The levels of ammonia remained low in the last ones when the algae cells were still present They increased when the cells had been ingered by the rotifers. Nevertheless,the rotifer population initial1y inocu1ated in a1- gae culture always show a better growth than the ones fed on1y with bread yeast.This fact seems to be independent of the ammo- nia concentration in the culture water

EFFECT ON GROWTH AND MUSCLE CONTENTS OF TURBOT (Scophthalmus maximus) USING DIETS WITH DIFFERENT LEVELS OF FAT, TOCOPHEROL AND L-CARNITINE.

This work studies growth in weight of 10 groups of turbot (S. maximus) fed on a diet in which fat, ó-tocopherol or L-Carnitine have been incorporated, or in other cases a combination of the these. Significant differences between the groups were found, which were determined through a MANOVA with a design of repeated measurements, being p<O.OOl for all groups. Those which presented higher growth ingested a dose of 300 mg of l-Carnitine and those presenting lower growth ingested fat (16% of dry food), without any other factors added. The protein and lipid content analyses in carcass and liver showa difference of fat accumulation, with values varying from 7 to 20% of humid weight for those treated with l-Carnitine, ó-tocopherol, and fat respectively according to treatment

First results obtained about the contents in lipid, protein, water, ash and free fatty-acids, in same species of sea-fish most commonly used in feeding in aquaculture

In this report; we introduce the first results obtained about the contents in Lipid, Protein, Water, and Ash of the following species: Bogue (Boops boops,L.), Horse mackerel (Trachurus trachurus,L.), Mackerel (Scomber scombrus, L.), Blue whiting (Micromesistius poutassou, R.). In Spain, these species are basicaly used as much for their fresh consumption as for the production of fodder and flour for Aquaculture At the same time, the contents in free fatty acids of the same species in different periods of cold conservation are introduced.A cette comunication nous presentons les premiers resultés obtenues du contenue de grases, proteines, humedité et cendres du suivantes species: Bogue (Boops boops, L.), Chinchard (Trachurus trachurus, L.), Maquereau (Scomber scombrus, L.) et Poutassou (Micromesistius poutassou,R.). Cettes espéces sont fondamentellement employees en Spagne autant pour son employee domestique comme pour la production de aliments et farines pour l'acuiculture. Au meme temps ont presente le contenue en acides grases libres des memes espéces en diferents periodes de conservation au froid

Growth of turbot (Scophthalmus maximus L.) from 1 to 3,000 g in the north of Spain

Growth of Turbot from 1 y. to 3000 g. is related in this paper. Groups of fish were fed on semihumid food. Gompertz's and Bertalanffy's equations were applied for growth in weight and length respectively. Parameters such as food conversion index and specific growth rate, as well as condition factor were calculated.Growth is presented as a curve-line for different intervals

Use of pyridoxine and ascorbic acid at different doses in turbot (Scophtalmus maximus) in experimental feeding.

This paper repported the use of different doses of pyridoxine combined with ascorbic acid in turbot oxidized diet. Growht of groups were compared with a variance analysis oneway, showing no significative differences between any groups (p>0.5). Also survival was analyzed by actuarial Method Cutler-Ederer with Breslow and Mantel-Cox tests. They showed differences between groups that were fed on less amount of B, and vitamin C combined than their homologue with double dose of both vitamins, (p<0.05), but no differences with thoses fed in B6, absent in diet. Finally all of them were compared with a qroup with no Pyridoxine and vitamin C, showing differences at level (p=0.0000) in survival.Cette communication rapporte l'utilisation de différents doses de piridoxine combinées avec de l'acid ascorbic dans une diete oxidée du turbot. La croissance des groups a été comparée avec une analyse de la variance d'une voie, ne montrant pas des différencés significatives entre les groups (p>0.05). La survivance a été analysée aussi, avec la métode Cutler-Ederer et les t-ests de Breslow et Mantel-Cox. Les différences furent significatives entre les groups qui avaient reÇu deux différent doses de piridoxine et de vitamin C (une dose avait deux fois la quantité chaque vitamine que l'autre) au niveau de p<0.05; mais elles ne le furent pas avec les groups qui nravaient pas recu de la vitamine B6, dans sa diète. Finalement tous les groups qui avaient recu quelque dose de vitamine C (avec ou sans vitamine B6,) ont été compares avec un group qui avait reÇu une diète sans piridoxine et sans vitamine C, résultant des différences en survivance significatives en tous les comparaisons (p=0.0000)

Effect of vitamin C on turbot (Scophthalmus maximus) using different experimental diets in feeding

The use of vitamin C on turbot has been repported in this paper. Groups of juvenile fish were fed in different diet, oxidated or not food combined whether or not with ascorbic acid. The growth of both groups were compared with oneway variance analysis, that showed no significative differences p>0.05. Also the effect of vitamin C on survival were analysed by actuarial method of Cutler-Ederer and groups compared by statistics of Breslow and Mantel-Cox. Groups feed on ascorbic acid(with oxidated food) showed significative differences with the equivalent without ascorbic acid (p=0.0000). Others groups did not show them (p>0.05).Dans ce papier, on montre l'utilization de la vitamine C par le turbot. Des groupes de poissons jeunes ont été alimentés avec des dietes différentes, oxydées et non oxydées, combinées avec et sans acide ascorbique. La croissance des deux groupes a été comparée avec un analysis de la variance unifactoriel, et n'a pas montré de différences significatives (p>0.05). On a aussi analysé l'effet de la vitamine sur la survie avec le méthode de Cutler-Ederer et les groupes ont été comparés avec le méthode statistique de Brestow et Mantel-Cox. Les groupes alimentés avec l'acide ascorbique (nourriture oxydée) ont montrés des dtfférences significatives avec le groupe sans acide ascorbique (p=0.0000). Des autres groupes ne le montrent pas (p>0.05)

Development of an activity disease score in patients with uveitis (UVEDAI)

To develop a disease activity index for patients with uveitis (UVEDAI) encompassing the relevant domains of disease activity considered important among experts in this field. The steps for designing UVEDAI were: (a) Defining the construct and establishing the domains through a formal judgment of experts, (b) A two-round Delphi study with a panel of 15 experts to determine the relevant items, (c) Selection of items: A logistic regression model was developed that set ocular inflammatory activity as the dependent variable. The construct "uveitis inflammatory activity" was defined as any intraocular inflammation that included external structures (cornea) in addition to uvea. Seven domains and 15 items were identified: best-corrected visual acuity, inflammation of the anterior chamber (anterior chamber cells, hypopyon, the presence of fibrin, active posterior keratic precipitates and iris nodules), intraocular pressure, inflammation of the vitreous cavity (vitreous haze, snowballs and snowbanks), central macular edema, inflammation of the posterior pole (the presence and number of choroidal/retinal lesions, vascular inflammation and papillitis), and global assessment from both (patient and physician). From all the variables studied in the multivariate model, anterior chamber cell grade, vitreous haze, central macular edema, inflammatory vessel sheathing, papillitis, choroidal/retinal lesions and patient evaluation were included in UVEDAI. UVEDAI is an index designed to assess the global ocular inflammatory activity in patients with uveitis. It might prove worthwhile to motorize the activity of this extraarticular manifestation of some rheumatic diseases