7,492 research outputs found
Endophytic Mycoflora of Indian Medicinal Plant, Terminalia arjuna and their Biological Activities
Studies were undertaken to isolate, identify and evaluate the biological activities of endophytic mycoflora of Indian medicinal plant, Terminalia arjuna. A total of 20 isolates of endophytic fungi were obtained from the leaves, twigs and bark tissues of the Terminalia arjuna. Out of 20, six isolates exhibited promising antibacterial, antifungal and anti-inflammatory activities when cultivated at shake flask level. The selected isolates were identified on the basis of morphology and ITS gene sequencing. Three isolates, designated as TA BA 1, TA L1 and TA L2 were identified as Aspergillus flavus whereas; the remaining three endophytic fungi were identified as Diaporthe arengae (TA TW2), Alternaria Sp. (TA TW1) and Lasiodiplodia theobromae (TA BA2). Aspergillus flavus was found as the predominant endophyte in leaves and bark tissues of the plant. The crude extract of the test isolates showed considerable antimicrobial activity against common human bacterial (Staphylococcus aureus, Escherichia coli, Pseudomonas aeruginosa, Proteus vulgaris, Salmonella abony and Bacillus subtilis) and fungal (Candida albicans, Aspergillus niger and Penicilium sp.) pathogens. The extract of Diaporthe arengae (TA TW2) significantly reduced the concentration of DPPH free radical as percent DPPH scavenging activity was found to be highest (69.56%) in comparison with other isolates. The % inhibition of hemolysis of RBCs was found to be highest (82.85%) with Diaporthe arengae (TA TW2) in comparison (83.26%) with standard drug (Ibuprofen). Among all, the extract of the Diaporthe arengae (TA TW2) showed excellent biological activities and hence was subjected to further characterization. The phytochemical investigation of the extract revealed the presence of terpenoids as the major phytoconstituents which was supported by TLC and UV spectroscopic studies. The results indicate that the isolated endophytes could be the valuable source of these bioactive molecules with diverse biological activities. The bioactivities may be attributed to the terpenoids present in the endophytic extract
Assessment of gestational diabetes mellitus development in correlation with elevated first trimester serum uric acid levels
Background: More than 10% of pregnancies in the world are affected with gestational diabetes mellitus (GDM), making it a prevalent pregnancy complication. The goal of this research was to examine whether or not higher serum uric acid levels in the first trimester of pregnancy are associated with an increased risk of developing GDM.Methods: The study was conducted on 56 first-trimester pregnant females at risk of GDM attending the outpatient clinic of the S. S. institute of medical sciences, Davanagere. All cases underwent estimation of uric acid levels <15 weeks, 24 to 28 weeks, and oral glucose challenge test (OGCT) at 24 to 28 weeks.Results: In our study, among 56 pregnant women, 17 (30.3%) developed GDM. Of these 12 women (70.6%) with GDM had higher uric acid levels and 5 women (29.4%) with GDM had normal uric acid levels. Uric acid levels were higher in women with a higher BMI.Conclusions: GDM development is significantly correlated with elevated serum uric acid levels in the first trimester. Early interventions by dietary and exercise regimes in these patients can reduce the maternal and neonatal complications
Genetic evaluation for understanding combining ability effects and Heterotic grouping in Maize (Zea mays L.)
Combining ability of the genotypes/lines is a major factor in planning the breeding programme and for development of Heterotic hybrids. In the present study, twenty maize inbred lines were crossed to three diverse testers CM-111, GPM-549 and GPM-581 and the resultant F1 hybrids were evaluated in an alpha lattice design. General combining ability of lines which is representation of additive gene action was found to be significant for all the quantitative traits. Specific combining ability which is indication of non-additive gene action was found to be significant for the traits number of kernel rows per cob, number of kernels per row, cob girth, cob length, test weight and grain yield. Lines VL-058725, VL-1018527 and VL-108723 produced heterotic hybrids in cross combination with any of the tester due to their high GCA effects. Whereas, the lines VL-0536, SNL-1574 and VL-109086 interacted positively with their testers thus producing heterotic hybrids with high positive SCA. GGE biplot analysis was helpful in visualizing the combining ability effects and identify heterotic pattern among theinbred lines. Heterotic grouping based on SCA and mean grain yield was able to classify thirteen of the twenty inbred lines into two distinct heterotic groups i.e., Heterotic group A and B consisting of six and seven lines respectively. Heterotic group A consisted of lines with high GCA whereas, heterotic group B with low GCA lines. SCA effect showed significant positive correlation with all the quantitative traits and played a prominent role in determining the performance of hybrids, thus indicating the importance of non-additive gene action in developingheterotic hybrids
The Schrodinger equation with Hulthen potential plus ring-shaped potential
We present the solutions of the Schrdinger equation with the
Hulthn potential plus ring-shape potential for states
within the framework of an exponential approximation of the centrifugal
potential.Solutions to the corresponding angular and radial equations are
obtained in terms of special functions using the conventional Nikiforov-Uvarov
method. The normalization constant for the Hulthn potential is also
computed.Comment: Typed with LateX,12 Pages, Typos correcte
A CMOS silicon spin qubit
Silicon, the main constituent of microprocessor chips, is emerging as a
promising material for the realization of future quantum processors. Leveraging
its well-established complementary metal-oxide-semiconductor (CMOS) technology
would be a clear asset to the development of scalable quantum computing
architectures and to their co-integration with classical control hardware. Here
we report a silicon quantum bit (qubit) device made with an industry-standard
fabrication process. The device consists of a two-gate, p-type transistor with
an undoped channel. At low temperature, the first gate defines a quantum dot
(QD) encoding a hole spin qubit, the second one a QD used for the qubit
readout. All electrical, two-axis control of the spin qubit is achieved by
applying a phase-tunable microwave modulation to the first gate. Our result
opens a viable path to qubit up-scaling through a readily exploitable CMOS
platform.Comment: 12 pages, 4 figure
Pauli spin blockade in CMOS double quantum dot devices
Silicon quantum dots are attractive candidates for the development of
scalable, spin-based qubits. Pauli spin blockade in double quantum dots
provides an efficient, temperature independent mechanism for qubit readout.
Here we report on transport experiments in double gate nanowire transistors
issued from a CMOS process on 300 mm silicon-on-insulator wafers. At low
temperature the devices behave as two few-electron quantum dots in series. We
observe signatures of Pauli spin blockade with a singlet-triplet splitting
ranging from 0.3 to 1.3 meV. Magneto-transport measurements show that
transitions which conserve spin are shown to be magnetic-field independent up
to B = 6 T.Comment: 5 pages , 4 figure
Measuring galaxy cluster masses with CMB lensing using a Maximum Likelihood estimator: Statistical and systematic error budgets for future experiments
We develop a Maximum Likelihood estimator (MLE) to measure the masses of
galaxy clusters through the impact of gravitational lensing on the temperature
and polarization anisotropies of the cosmic microwave background (CMB). We show
that, at low noise levels in temperature, this optimal estimator outperforms
the standard quadratic estimator by a factor of two. For polarization, we show
that the Stokes Q/U maps can be used instead of the traditional E- and B-mode
maps without losing information. We test and quantify the bias in the recovered
lensing mass for a comprehensive list of potential systematic errors. Using
realistic simulations, we examine the cluster mass uncertainties from
CMB-cluster lensing as a function of an experiment's beam size and noise level.
We predict the cluster mass uncertainties will be 3 - 6% for SPT-3G, AdvACT,
and Simons Array experiments with 10,000 clusters and less than 1% for the
CMB-S4 experiment with a sample containing 100,000 clusters. The mass
constraints from CMB polarization are very sensitive to the experimental beam
size and map noise level: for a factor of three reduction in either the beam
size or noise level, the lensing signal-to-noise improves by roughly a factor
of two.Comment: 28 pages, 5 figures: figs 2, 3 updated, references added: accepted
for publication in JCA
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