Secured Data Outsourcing in Cloud Computing

Cloud computing is a popular technology in the IT world. After internet, it is the biggest thing for IT world. Cloud computing uses the Internet for performing the task on the computer and it is the next- generation architecture of IT Industry. It is related to different technologies and the convergence of various technologies has emerged to be called as cloud computing. It places the application software and databases to the huge data centers, where the supervision of the data and services may not be fully trusted. This unique attribute poses many new security challenges which have not been well understood. In this paper, we develop system which allows customer to use cloud server with various profits and strong securities. So when customer stores his sensitive data on cloud server he should not worry about securities, we also protect customer’s account from malicious behaviors by verifying the result. This result verification mechanism is highly efficient for both cloud server and cloud customer. Covering security analysis and experiment results shows the immediate practicability of our mechanism design. DOI: 10.17762/ijritcc2321-8169.150314

COAGULATION PARAMETERS AS PREDICTORS OF OUTCOMES IN SNAKE BITE ENVENOMATION: A PROSPECTIVE STUDY IN RURAL INDIA

Snake bites are a serious concern in rural areas and are a major cause of morbidity and mortality globally. Activated Partial Thromboplastin Time (APTT) and Prothrombin Time (PT), in particular, are the focus of this study's investigation of the association between coagulation parameters and the consequences of snake bite envenomation. Materials and Methods: At Krishna Institute Medical Sciences, Karad, 100 patients who had been admitted with snake bites to the Medical Intensive Care Unit were the subject of an 18-month prospective study (November 2020–April 2022). The study looked at coagulation factors, clinical characteristics, and consequences. Statistical analysis methods, such as t-tests and chi-square tests, were used with OpenEpi Software version 2.3 and SPSS version 21. Results: Vipers were to blame for 80% of the bites among the 100 patients, mostly on the lower limbs (78%). In 85% of the cases, there were fang marks, and in 56% of them, there was bleeding. Renal failure (26.7%) and cellulitis (13.3%) were among the complications (30%). In 80% and 70% of difficult cases, respectively, prolonged APTT and PT were noted. All of the deaths had extended APTT and PT, with a mortality rate of 7%. Conclusion: Prolonged APTT and PT at appearance were related to issues and death, highlighting their importance as indicators of how a snake bite envenomation will turn out. Health care professionals use coagulation measures like APTT and PT as crucial markers to help them make decisions and improve patient outcomes

Application of Innovative Cost effective flow resistivity measurement system for Acoustic Performance Analysis of Natural fibers

In design of the interior of car, workplace and companies, acoustic material plays very important role. To attenuate unwanted noise, passive noise control technique using acoustic material is used extensively. The non-biodegradable synthetic acoustic material, which are used nowadays cause environmental pollution. This environmental pollution motivates researchers to find eco-friendly and sustainable acoustic materials as an alternative sound absorber. Research is going on to find new acoustic materials for many industrial and domestic applications. The value of sound absorption coefficient has correlation with frequency of sound. Hence, it would be very helpful if the characteristic acoustic properties of these materials are known prior using them for a particular application. This paper presents the utilization of new flow resistivity measurement set up. This flow resistivity set up is developed as per ASTM C522-03 standard. Delany-Bazley model can be used to predict sound absorption coefficient using flow resistivity values. The numerical analysis using MATLAB program based on Delany-Bazley models is made to determine sound absorption coefficient of material prepared from natural fibers of sugarcane waste, wheat straw and PU foam, Glass wool. The sound absorption coefficients of all four materials are also obtained by experimental investigation using impedance tube as per ASTM E 1050 standard. Comparisons of the experimental and the numerical results confirm that the sound absorption coefficients of all material are well corroborated

Compressed Natural Gas Operated Two-Wheeler

In this paper the results obtained on a 110cc two-wheeler S.I. engine using both petrol and CNG as fuel. Tests like Acceleration test, Emission test, Mileage test and Exhaust noise test were conducted at different operating condition. The basic petrol engine is converted into a bi-fuel engine and regulated by means of an electronically controlled Solenoid Actuated Valve system. On a comparative analysis CNG fuelled engine accelerated slower compared to petrol fuelled engine, but the CO and CO2 emissions were lesser indicated that CNG when used as fuel accelerates at a faster rate, the emission of hazardous gases is comparatively far lower than petrol, fuel consumption of CNG is less and it is economical. The noise test shows that the exhaust of CNG is louder as compared to petrol

Health Detector Android Application using IOT for Rural Area

Technology is being increasing rapidly day by day. Growing technology make user to use different devices and integrate all of them in one frame, so as to reduce implementation cost and increase functionality of module and that will be implemented. Health Detector application is a good platform to measure different health parameters via sensors. Integrating whole system with android will make it available and useful. Pulse rate sensor and ECG sensors are easily available with the moderate worth hence it is affordable to the end user. This system will be an elixir for the people who are living scurry life. Android platform help to add different functionalities like disease prediction on the basis of symptoms stored into SQLite database, calling ambulance on emergency mode, locating nearest hospitals, medicals and blood bank on an emergency mode via GPS sensors. Regular health check-ups like heartbeat, BMI is also provided

Identification of genetic polymorphisms in DNA repair xenoderma pigmentosum group D gene and its association with head and neck cancer susceptibility in rural Indian population: a hospital based case-control study from south-western Maharashtra, India

Background: Smoking and alcohol related head and neck cancer is a major concern of health risk in developing countries, such as India. In this study, we aimed to determine the frequency of polymorphisms in DNA repair gene, xeroderma pigmentosum complementation group D (XPD) at codon (cd) 156, cd199, cd320, cd751 in patients of oral cancer from South-Western Maharashtra, India and to evaluate their association with oral cancer development.Methods: We used polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) to analyze XPD gene polymorphisms in 320 patients with oral cancer and in 400 age and sex matched disease-free controls.Results: There was no significant difference in the genotype distribution between oral cancer patients and controls for each polymorphism (p>0.05) except XPD199. The result from our study showed that allele frequencies of selected genes were not statistically different between the groups for XPD Arg156, XPD Asn320, XPD Gln751. XPDMet199 (OR=29.44; 95% CI= (18.47-46.92); p≤0.0001) genotypes significantly increased the risk of head and neck cancer.Conclusions: This study indicates that polymorphisms in cd199 of XPD gene could play a role in modifying genetic susceptibility of individual to head and neck cancer inMaharashtra patients. Thus, the case-control study suggest that selected DNA repair genes represent genetic determinants in oral carcinogenesis along with other risk factors in the rural Indian population.

A disordered region controls cBAF activity via condensation and partner recruitment

Intrinsically disordered regions (IDRs) represent a large percentage of overall nuclear protein content. The prevailing dogma is that IDRs engage in non-specific interactions because they are poorly constrained by evolutionary selection. Here, we demonstrate that condensate formation and heterotypic interactions are distinct and separable features of an IDR within the ARID1A/B subunits of the mSWI/SNF chromatin remodeler, cBAF, and establish distinct sequence grammars underlying each contribution. Condensation is driven by uniformly distributed tyrosine residues, and partner interactions are mediated by non-random blocks rich in alanine, glycine, and glutamine residues. These features concentrate a specific cBAF protein-protein interaction network and are essential for chromatin localization and activity. Importantly, human disease-associated perturbations in ARID1B IDR sequence grammars disrupt cBAF function in cells. Together, these data identify IDR contributions to chromatin remodeling and explain how phase separation provides a mechanism through which both genomic localization and functional partner recruitment are achieved

Genetic Drivers of Heterogeneity in Type 2 Diabetes Pathophysiology

Type 2 diabetes (T2D) is a heterogeneous disease that develops through diverse pathophysiological processes1,2 and molecular mechanisms that are often specific to cell type3,4. Here, to characterize the genetic contribution to these processes across ancestry groups, we aggregate genome-wide association study data from 2,535,601 individuals (39.7% not of European ancestry), including 428,452 cases of T2D. We identify 1,289 independent association signals at genome-wide significance (P \u3c 5 × 10-8) that map to 611 loci, of which 145 loci are, to our knowledge, previously unreported. We define eight non-overlapping clusters of T2D signals that are characterized by distinct profiles of cardiometabolic trait associations. These clusters are differentially enriched for cell-type-specific regions of open chromatin, including pancreatic islets, adipocytes, endothelial cells and enteroendocrine cells. We build cluster-specific partitioned polygenic scores5 in a further 279,552 individuals of diverse ancestry, including 30,288 cases of T2D, and test their association with T2D-related vascular outcomes. Cluster-specific partitioned polygenic scores are associated with coronary artery disease, peripheral artery disease and end-stage diabetic nephropathy across ancestry groups, highlighting the importance of obesity-related processes in the development of vascular outcomes. Our findings show the value of integrating multi-ancestry genome-wide association study data with single-cell epigenomics to disentangle the aetiological heterogeneity that drives the development and progression of T2D. This might offer a route to optimize global access to genetically informed diabetes care

Genetic drivers of heterogeneity in type 2 diabetes pathophysiology

Type 2 diabetes (T2D) is a heterogeneous disease that develops through diverse pathophysiological processes1,2 and molecular mechanisms that are often specific to cell type3,4. Here, to characterize the genetic contribution to these processes across ancestry groups, we aggregate genome-wide association study data from 2,535,601 individuals (39.7% not of European ancestry), including 428,452 cases of T2D. We identify 1,289 independent association signals at genome-wide significance (P &lt; 5 × 10-8) that map to 611 loci, of which 145 loci are, to our knowledge, previously unreported. We define eight non-overlapping clusters of T2D signals that are characterized by distinct profiles of cardiometabolic trait associations. These clusters are differentially enriched for cell-type-specific regions of open chromatin, including pancreatic islets, adipocytes, endothelial cells and enteroendocrine cells. We build cluster-specific partitioned polygenic scores5 in a further 279,552 individuals of diverse ancestry, including 30,288 cases of T2D, and test their association with T2D-related vascular outcomes. Cluster-specific partitioned polygenic scores are associated with coronary artery disease, peripheral artery disease and end-stage diabetic nephropathy across ancestry groups, highlighting the importance of obesity-related processes in the development of vascular outcomes. Our findings show the value of integrating multi-ancestry genome-wide association study data with single-cell epigenomics to disentangle the aetiological heterogeneity that drives the development and progression of T2D. This might offer a route to optimize global access to genetically informed diabetes care.</p

Adding 6 months of androgen deprivation therapy to postoperative radiotherapy for prostate cancer: a comparison of short-course versus no androgen deprivation therapy in the RADICALS-HD randomised controlled trial

Background Previous evidence indicates that adjuvant, short-course androgen deprivation therapy (ADT) improves metastasis-free survival when given with primary radiotherapy for intermediate-risk and high-risk localised prostate cancer. However, the value of ADT with postoperative radiotherapy after radical prostatectomy is unclear. Methods RADICALS-HD was an international randomised controlled trial to test the efficacy of ADT used in combination with postoperative radiotherapy for prostate cancer. Key eligibility criteria were indication for radiotherapy after radical prostatectomy for prostate cancer, prostate-specific antigen less than 5 ng/mL, absence of metastatic disease, and written consent. Participants were randomly assigned (1:1) to radiotherapy alone (no ADT) or radiotherapy with 6 months of ADT (short-course ADT), using monthly subcutaneous gonadotropin-releasing hormone analogue injections, daily oral bicalutamide monotherapy 150 mg, or monthly subcutaneous degarelix. Randomisation was done centrally through minimisation with a random element, stratified by Gleason score, positive margins, radiotherapy timing, planned radiotherapy schedule, and planned type of ADT, in a computerised system. The allocated treatment was not masked. The primary outcome measure was metastasis-free survival, defined as distant metastasis arising from prostate cancer or death from any cause. Standard survival analysis methods were used, accounting for randomisation stratification factors. The trial had 80% power with two-sided α of 5% to detect an absolute increase in 10-year metastasis-free survival from 80% to 86% (hazard ratio [HR] 0·67). Analyses followed the intention-to-treat principle. The trial is registered with the ISRCTN registry, ISRCTN40814031, and ClinicalTrials.gov, NCT00541047. Findings Between Nov 22, 2007, and June 29, 2015, 1480 patients (median age 66 years [IQR 61–69]) were randomly assigned to receive no ADT (n=737) or short-course ADT (n=743) in addition to postoperative radiotherapy at 121 centres in Canada, Denmark, Ireland, and the UK. With a median follow-up of 9·0 years (IQR 7·1–10·1), metastasis-free survival events were reported for 268 participants (142 in the no ADT group and 126 in the short-course ADT group; HR 0·886 [95% CI 0·688–1·140], p=0·35). 10-year metastasis-free survival was 79·2% (95% CI 75·4–82·5) in the no ADT group and 80·4% (76·6–83·6) in the short-course ADT group. Toxicity of grade 3 or higher was reported for 121 (17%) of 737 participants in the no ADT group and 100 (14%) of 743 in the short-course ADT group (p=0·15), with no treatment-related deaths. Interpretation Metastatic disease is uncommon following postoperative bed radiotherapy after radical prostatectomy. Adding 6 months of ADT to this radiotherapy did not improve metastasis-free survival compared with no ADT. These findings do not support the use of short-course ADT with postoperative radiotherapy in this patient population