Review of Hridroga W.S.R. to the Ischemic Heart Disease

Hridroga (Heart disease) is very common in present scenario due to the sedentary life style and increase psychosocial stress. The major causative factors for heart problems are cigarette smoking, tobacco chewing, alcohol consumption, junk foods and obesity. According to WHO Ischemic heart disease or Coronary artery disease is the major causes of mortality. Therefore, it is needed to explore knowledge on heart disease time to time. The main purpose of this article is to promote the awareness about the heart disease, so prevalence of such problem can be reduced by avoiding risk factors. Keywords: Hridroga, Hritshool, Heart disease, Ayurveda, IHD (Ischemic Heart Diseases)

Prevalence of diphtheria in a tertiary care hospital of Western part of India – A clinicoepidemiological study

Background: Diphtheria, a very common vaccine-preventable disease, is still persistent in India without much decline in the past decade. Objective: The objective of this study was to study the clinicoepidemiological profile of diphtheria in children up to 12 years of age, their outcome in tertiary care hospital of Western Gujarat. Materials and Methods: This prospective observational study was conducted among 164 children admitted in the tertiary hospital of Western Gujarat, who were diagnosed with during the period of July 2016–August 2018. Results: It was observed that the highest prevalence of diphtheria was seen in the age group of 5–9 years. There was slight male preponderance with 1.5:1. The majority of patients were referred from rural areas. Immunization status was the most determining feature as 68 patients out of the study population were unimmunized at the time of admission. Conclusion: The rise in the prevalence in more advanced age group of 8–12 years might be due to waning immunity and emphasizes on the need for increasing primary immunization coverage along with both booster doses in areas having less adequate health-care facilities or poor access

AYURVEDA PERSPECTIVE ON MOOTRASHMARI AND ITS MANAGEMENT: AN LITERATURE BASED REVIEW

The formation of stone is one of the common problems of urinary system and as per modern science only few medicines are available for such condition along with surgery. It is second most common disease of urinary tract with high recurrence rate. The common symptoms of ureter culculi are pain, haematuria, burning micturiton, dysurea, tenderness and sometimes fever. Ayurveda described Mootrashmari as urinary calculus disease of Mutravaha Srotas and considered as Asthamahagada. Ayurveda described various treatment approaches for the management of disease; use of herbs, ayurveda formulation and Kshara, etc. this article presented summarative review on Mootrashmari. Keywords: Ayurveda, Ashmari, Mutravaha Srotas, Mootrashmar

Evaluation of genetic diversity in different genotypes of Gerbera jamesonii Bolus using random amplified polymorphic DNA (RAPD) markers

Genetic diversity within Gerbera jamesonii Bolus is the key to genetic improvement of this important ornamental species. In the present study, genetic diversity of 12 accessions of gerbera was assessed through random amplified polymorphic DNA (RAPD) markers. A total of 40 RAPD primers belonging to OPD, OPE, OPF and OPG series of universal primers set were used out of which, only 10 primers produced clear, reproducible and scorable bands. Ten (10) decamer RAPD primers produced a total of 49 scorable bands from 12 genotypes of G. jamesonii Bolus, out of which 42 were polymorphic and seven were monomorphic. The percentage of polymorphism ranged from a maximum of 100.00% by OPE-02, OPE-14, OPF-18, OPG-18, OPG-16 and OPG-17 to a minimum of 50.00% by OPE-08. The RAPD profiles generated were further evaluated for studying the Jaccard’s similarity coefficient. The average genetic similarity coefficient for the 12 accessions evaluated by Jaccard index was 0.66 ranging from 0.35 to 0.86. The RAPD amplification data were used to obtain similarity matrix and for generation of dendrogram using unweighted pair group method with arithmetic averages (UPGMA) method. Based on the dendrogram, all 12 genotypes could be distinctly divided into two clusters and the accession CF Orange was found most dissimilar from other accessions. This study shows that DNA based molecular marker RAPD is a powerful, less time consuming and cost effective molecular technique for assessment of genetic diversity among different genotypes of G. jamesonii Bolus. The availability of these gerbera RAPD markers would facilitate the use of molecular markers in gerbera breeding and genetic studiesKeywords: Gerbera jamesonii Bolus, molecular markers, genetic diversity, RAPDAfrican Journal of Biotechnology, Vol. 13(10), pp. 1117-1122, 5 March, 201

A Review on Role of Shankhpushpi Kalka and Yashtimadhu Taila Shirodhara towards the Management of Anidra

Insomnia (Anidra) is one of the common health issues of current global scenario and number of such patients increases day by day sue to the diversified living pattern. The disease mainly associated with mental anxiety, grief, anger, depression and presence of other disease conditions. The modern medical science utilizes antipsychotic, sedatives and anti-depressant medicine for the management of insomnia while Ayurveda focuses to pacify disease pathology through Shodhna; Shirodhara, Nasya karma, Murdhni Chikitsa, use of natural herbs and Ayurveda formulations. The Ayurveda formulations containing herbs like Shankhpushpi and Yashtimadhu offers beneficial effects in Anidra, therefore in present article we emphasizes role of some classical therapies for the management of Anidra. Keywords: Ayurveda, Anidra, Shankhpushpi, Shirodhara, Yashtimadh

Case Report Icatibant in the Treatment of Angiotensin-Converting Enzyme Inhibitor-Induced Angioedema

We describe the case of a 75-year-old woman who presented with massive tongue and lip swelling secondary to angiotensinconverting enzyme inhibitor-induced angioedema. An awake fibre-optic intubation was performed because of impending airway obstruction. As there was no improvement in symptoms after 72 hours, the selective bradykinin B2 receptor antagonist icatibant (Firazyr) was administered and the patient's trachea was successfully extubated 36 hours later. To our knowledge this is the first documented case of icatibant being used for the treatment of angiotensin-converting enzyme inhibitor-induced angioedema in the United Kingdom and represents a novel therapeutic option in its management

Chiral emergence in multistep hierarchical assembly of achiral conjugated polymers

Intimately connected to the rule of life, chirality remains a long-time fascination in biology, chemistry, physics and materials science. Chiral structures, e.g., nucleic acid and cholesteric phase developed from chiral molecules are common in nature and synthetic soft materials. While it was recently discovered that achiral but bent core mesogens can also form chiral helices, the assembly of chiral microstructures from achiral polymers has rarely been explored. Here, we reveal chiral emergence from achiral conjugated polymers for the first time, in which hierarchical helical structures are developed through a multistep assembly pathway. Upon increasing concentration beyond a threshold volume fraction, pre-aggregated polymer nanofibers form lyotropic liquid crystalline (LC) mesophases with complex, chiral morphologies. Combining imaging, X-ray and spectroscopy techniques with molecular simulations, we demonstrate that this structural evolution arises from torsional polymer molecules which induce multiscale helical assembly, progressing from nano- to micron scale helical structures as the solution concentration increases. This study unveils a previously unknown complex state of matter for conjugated polymers that can pave way to a new field of chiral (opto)electronics. We anticipate that hierarchical chiral helical structures can profoundly impact how conjugated polymers interact with light, transport charges, and transduce signals from biomolecular interactions and even give rise to properties unimagined before.Comment: 47 pages, 7 figure

INTERNATIONAL JOURNAL OF PHARMACY & LIFE SCIENCES Dendrimers-a novel drug delivery system

Abstract Dendrimers are the polymeric materials for targeted delivery of drug molecule. These are the highly branched nanoscopic structure for the potential delivery of bioactive. The structure of these materials has a great impact on their physical and chemical properties. As a result of their unique behaviour dendrimers are suitable for a wide range of biomedical and industrial applications. The bioactive agents can be easily encapsulated into the interior of the dendrimers or chemically attached i.e. conjugated or physically adsorbed onto the dendrimer surface, serving the desired properties of the carrier to the specific needs of the active material and its therapeutic applications. In addition to supplying a multivalent backbone for drug attachment, dendrimers also provide access to various new polymer architectures that are potentially relevant to drug delivery applications. Through this review we are mainly focusing on the various properties and applications of dendrimer in pharmaceutical sciences

Interstitial Lung Abnormalities After Hospitalization for Covid-19 in Patients With Cancer: A Prospective Cohort Study

INTRODUCTION: Survivors of SARS-CoV-2 pneumonia often develop persistent respiratory symptom and interstitial lung abnormalities (ILAs) after infection. Risk factors for ILA development and duration of ILA persistence after SARS-CoV-2 infection are not well described in immunocompromised hosts, such as cancer patients. METHODS: We conducted a prospective cohort study of 95 patients at a major cancer center and 45 patients at a tertiary referral center. We collected clinical and radiographic data during the index hospitalization for COVID-19 pneumonia and measured pneumonia severity using a semi-quantitative radiographic score, the Radiologic Severity Index (RSI). Patients were evaluated in post-COVID-19 clinics at 3 and 6 months after discharge and underwent comprehensive pulmonary evaluations (symptom assessment, chest computed tomography, pulmonary function tests, 6-min walk test). The association of clinical and radiological factors with ILAs at 3 and 6 months post-discharge was measured using univariable and multivariable logistic regression. RESULTS: Sixty-six (70%) patients of cancer cohort had ILAs at 3 months, of whom 39 had persistent respiratory symptoms. Twenty-four (26%) patients had persistent ILA at 6 months after hospital discharge. In adjusted models, higher peak RSI at admission was associated with ILAs at 3 (OR 1.5 per 5-point increase, 95% CI 1.1-1.9) and 6 months (OR 1.3 per 5-point increase, 95% CI 1.1-1.6) post-discharge. Fibrotic ILAs (reticulation, traction bronchiectasis, and architectural distortion) were more common at 6 months post-discharge. CONCLUSIONS: Post-COVID-19 ILAs are common in cancer patients 3 months after hospital discharge, and peak RSI and older age are strong predictors of persistent ILAs

Integrated genome-wide chromatin occupancy and expression analyses identify key myeloid pro-differentiation transcription factors repressed by Myb

To gain insight into the mechanisms by which the Myb transcription factor controls normal hematopoiesis and particularly, how it contributes to leukemogenesis, we mapped the genome-wide occupancy of Myb by chromatin immunoprecipitation followed by massively parallel sequencing (ChIP-Seq) in ERMYB myeloid progenitor cells. By integrating the genome occupancy data with whole genome expression profiling data, we identified a Myb-regulated transcriptional program. Gene signatures for leukemia stem cells, normal hematopoietic stem/progenitor cells and myeloid development were overrepresented in 2368 Myb regulated genes. Of these, Myb bound directly near or within 793 genes. Myb directly activates some genes known critical in maintaining hematopoietic stem cells, such as Gfi1 and Cited2. Importantly, we also show that, despite being usually considered as a transactivator, Myb also functions to repress approximately half of its direct targets, including several key regulators of myeloid differentiation, such as Sfpi1 (also known as Pu.1), Runx1, Junb and Cebpb. Furthermore, our results demonstrate that interaction with p300, an established coactivator for Myb, is unexpectedly required for Myb-mediated transcriptional repression. We propose that the repression of the above mentioned key pro-differentiation factors may contribute essentially to Myb’s ability to suppress differentiation and promote self-renewal, thus maintaining progenitor cells in an undifferentiated state and promoting leukemic transformation