A retrospective study of 50 cases of lower limb soft tissue infection and its different modalities of presentation and its management

Background: Soft tissue infections are common in everyday practice. They show great variations in their severity. Skin and soft tissue infections are usually preceded by minor traumatic events. Among them soft tissue bacterial infections of lower limbs are more common. Patients having diabetes makes the scenario even worst. Diagnosis, intervention and treatment of these infections are very important. This study aims at understanding the pathology involved for lower limb soft tissue infections, spectrum of organisms and different treatment modalities in various age group and gender.Methods: 50 cases of lower limb soft tissue infections were included in this study. Detailed history, clinical examination, investigations, pre-operative preparation, intraoperative details and post-operative management were included.Results: 94% patients were having history of trauma.88% patients were having history of diabetes. Staphylococcus aureus was the most common (43%) organism cultured from swabs followed by pseudomonas (36%) out of total cases. Minimum stay in hospital was of 4 days to a maximum of 34 days. Most of the patients were managed with regular dressing and debridement.Conclusions: The patients sought treatment only when they had extensive lesions which affect their daily living. Health education regarding foot care forms an integral part of surgical management of lower limb soft tissue infections. Readmissions are mainly due to inadequate local control or fluctuating blood sugar levels and improper foot care due to illiteracy, poverty, ignorance and lack of adequate primary care facilities

Spadin, a Sortilin-Derived Peptide, Targeting Rodent TREK-1 Channels: A New Concept in the Antidepressant Drug Design

We found that spadin, a natural peptide derived from sortilin, blocks the mouse TREK-1 channel and might be an efficient and fast-acting antidepressant

An Epidemiological Analysis of SARS-CoV-2 Genomic Sequences from Different Regions of India

The number of Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) cases is increasing in India. This study looks upon the geographic distribution of the virus clades and variants circulating in different parts of India between January and August 2020. The NPS/OPS from representative positive cases from different states and union territories in India were collected every month through the VRDLs in the country and analyzed using next-generation sequencing. Epidemiological analysis of the 689 SARS-CoV-2 clinical samples revealed GH and GR to be the predominant clades circulating in different states in India. The northern part of India largely reported the ‘GH’ clade, whereas the southern part reported the ‘GR’, with a few exceptions. These sequences also revealed the presence of single independent mutations—E484Q and N440K—from Maharashtra (first observed in March 2020) and Southern Indian States (first observed in May 2020), respectively. Furthermore, this study indicates that the SARS-CoV-2 variant (VOC, VUI, variant of high consequence and double mutant) was not observed during the early phase of virus transmission (January–August). This increased number of variations observed within a short timeframe across the globe suggests virus evolution, which can be a step towards enhanced host adaptation