Escenarios de aprendizajes en el año 2030 en la educación de adolescentes, jóvenes y adultos: entramado didáctico

Fil: Ferreyra, Horacio Ademar. Universidad Católica de Córdoba. Facultad de Educación; ArgentinaFil: Labate, Hugo Alberto. Universidad Católica de Córdoba. Facultad de Educación; ArgentinaFil: Blanas de Marengo, Georgia Estela. Universidad Católica de Córdoba. Facultad de Educación; ArgentinaFil: Pasut, Marta.Universidad Católica de Córdoba. Facultad de Educación; ArgentinaFil: Rosales, Marcela Alejandra. Universidad Católica de Córdoba. Facultad de Educación; ArgentinaFil: Vidales, Silvia Noemí. Universidad Católica de Córdoba. Facultad de Educación; Argentin

Escenarios de aprendizajes en el año 2030 en la educación de adolescentes, jóvenes y adultos : entramado didáctico

Fil: Ferreyra, Horacio Ademar. Universidad Católica de Córdoba. Facultad de Educación; ArgentinaFil: Labate, Hugo Alberto. Universidad Católica de Córdoba. Facultad de Educación; ArgentinaFil: Blanas de Marengo, Georgia Estela. Universidad Católica de Córdoba. Facultad de Educación; ArgentinaFil: Pasut, Marta.Universidad Católica de Córdoba. Facultad de Educación; ArgentinaFil: Rosales, Marcela Alejandra. Universidad Católica de Córdoba. Facultad de Educación; ArgentinaFil: Vidales, Silvia Noemí. Universidad Católica de Córdoba. Facultad de Educación; Argentin

Educación secundaria Argentina. Reflexiones para superar el diagnóstico y avanzar hacia su transformación.

En esta entrevista grupal con la RIE, el grupo de investigación integrado por Dr. Horacio Ferreyra (coordinador), Lic. María Jacinta Eberle, Mgter. Griselda Gallo, Lic. Cecilia Larrovere, Dr. Mónica Luque, Lic. Marta Pasut, Prof. Gabriela Peretti y Prof. Rubén Rimondino, que el pasado 11 de septiembre de 2008 recibiera el Premio Domingo Faustino Sarmiento que otorga la Academia Nacional de Educación (Argentina), comparten algunas reflexiones sobre la educación secundaria con el propósito de alimentar el debate en torno a este nivel educativo.Fil: Ferreyra, Horacio Ademar. Universidad Católica de Córdoba. Facultad de Educación; Argentin

Educación secundaria Argentina. Reflexiones para superar el diagnóstico y avanzar hacia su transformación

En esta entrevista grupal con la RIE, el grupo de investigación integrado por Dr. Horacio Ferreyra (coordinador), Lic. María Jacinta Eberle, Mgter. Griselda Gallo, Lic. Cecilia Larrovere, Dr. Mónica Luque, Lic. Marta Pasut, Prof. Gabriela Peretti y Prof. Rubén Rimondino, que el pasado 11 de septiembre de 2008 recibiera el Premio Domingo Faustino Sarmiento que otorga la Academia Nacional de Educación (Argentina), comparten algunas reflexiones sobre la educación secundaria con el propósito de alimentar el debate en torno a este nivel educativo.Fil: Ferreyra, Horacio Ademar. Universidad Católica de Córdoba. Facultad de Educación; Argentin

De aprendizajes, competencias y capacidades en la educación primaria. Desandando caminos para construir nuevos senderos…

Fil: Ferreyra, Horacio Ademar. Universidad Católica de Córdoba. Facultad de Educación; Argentin

Bulk airflow measurements in a large naturally ventilated atrium in a mild climate

In recent years, concerns about global warming and greenhouse gas emissions have motivated designers to reduce building energy consumption through the implementation of passive solutions without compromising users’ thermal comfort. This evidence has stimulated a renewed interest in designers for the exploitation of natural ventilation as means of passive cooling solutions. The adoption of ventilative cooling is particularly suitable for large spaces (non-residential buildings) as a measure to reduce the HVAC system high cooling loads. Due the inability to control and ensure a constant airflow rate through natural ventilation most of the times designers choice goes towards mixed-mode buildings. Mixed-mode buildings are designed in such a way that the HVAC system acts as backup to prevent uncomfortable conditions when natural ventilation is not sufficient to guarantee a comfortable environment. Unfortunately, information about the actual performance of mixed-mode buildings is difficult to obtain due the difficulties to set up measurements in naturally ventilated buildings that highly depend on building geometry and outdoor conditions (weather, pollution and noise). This limitation leads designers to follow a traditional design approach based on mechanical air conditioned systems. With the aim of reducing the lack of information about the actual performance of mixed-mode non-residential buildings, this paper presents a full-scale bulk air flow measurements for a large naturally ventilated atrium in a mild climate. The methodology and the results presented in this paper refers at the first step of a more complete and complex work which aims at assessing the performance of the large mixed-mode atrium. The general performance of the atrium are tested through a long term measurement campaign which is indeed ongoing. The final aim is to quantify the effect of ventilative night cooling in term of cooling energy reduction and indoor thermal environment

Overcoming Cancer Cell Drug Resistance by a Folic Acid Targeted Polymeric Conjugate of Buthionine Sulfoximine

Background: Glutathione (GSH), which is the predominant low molecular weight intracellular thiol in mammals, has multiple functions, such as those of protecting against oxidative stress and detoxifying endogenous and exogenous electrophiles. High GSH levels, which have been observed in various types of tumors, have been thought to contribute to the resistance of neoplastic cells to apoptotic stimuli triggered by pro-oxidant therapy. Although L-(S,R)-buthionine sulfoximine (BSO), a selective irreversible inhibitor of glutamate cysteine ligase, depletes GSH in vitro and in in vivo and sensitizes tumor cells to radiation and some cancer chemotherapeutics, its toxicity and short in vivo half-life have limited its application to combination anticancer therapies. Objective: To demonstrate that a folate-targeted PEGylated BSO conjugate can sensitize cancer cells to a reactive oxygen species (ROS)-generating anticancer agent by depleting GSH. Method: A novel folate-targeted PEGylated-BSO conjugate was synthesized and tested in combination with gemcitabine in human cell lines that over-express (HeLa) or do not express (A549) the folate receptor. Results: The prepared folate-PEG-GFLG-BSO conjugate proved to be efficacious in reducing GSH levels and, when used in combination with the pro-oxidant drug gemcitabine, it enhanced drug activity in the cell line overexpressing the folate receptor. Conclusion: The folate-PEG-GFLG-BSO conjugate studied was found to be effective in sensitizing folate-receptor positive cancer cells to the ROS-generating drug gemcitabine

A hyaluronic acid-salmon calcitonin conjugate for the local treatment of osteoarthritis: Chondro-protective effect in a rabbit model of early OA

Osteoarthritis (OA) is characterized by chronic degeneration of joints, involving mainly the articular cartilage and the underlying bone, and severely impairing the quality of life of the patient. Although with limited efficacy, currently available pharmacological treatments for OA aim to control pain and to retard disease progression. Salmon calcitonin (sCT) is a drug which has been shown to have therapeutic effects in experimental arthritis by inhibiting both bone turnover and cartilage degradation and reducing the activities of matrix metalloproteinases (MMP). High molecular weight hyaluronic acid (HA) is used as a lubricant in OA therapy, and, interestingly, HA polymers may normalize the levels of MMP-1, -3 and -13. We demonstrated that sCT rapidly clears from the knee joint of rat animal model, after intra-articular (i.a.) administration, and it induces systemic effects. Here, sCT was conjugated to HA (200 kDa) with the aim of prolonging the residence time of the polypeptide in the joint space by reducing its clearance. An aldehyde derivative of HA was used for N-terminal site-selective coupling of sCT. The activity of sCT was preserved, both in vitro and in vivo, after its conjugation and the i.a. injection of HA-sCT did not trigger any systemic effects in rats. The efficacy of HA-sCT treatment was tested in a rabbit OA model and clear chondro-protective effect was proven by macro-and microscopic assessments and histological findings. Our results indicate that HAylation of sCT increases the size of the polypeptide in a stable covalent manner and delays its passage into the blood stream. We conclude that HA conjugation prolongs the anti-catabolic effects of sCT in joint tissues, including the synovial membrane and cartilage. (C) 2014 Elsevier B. V. All rights reserved

Guidelines on how to approach the energy-efficient retrofitting of shopping centres

Special architectural conditions and needs are common in almost all shopping centres. The main retrofit drivers are: (i) improve the indoor environmental quality and functionality, to enhance the customers experience; (ii) reduce the energy consumption; (iii) optimize the building operation and relative maintenance costs and (iv) improve the overall sustainability level reducing the environmental, social, and economic impact. Shopping centres vary in their functions, typologies, forms and size, as well as the (shopping) trip purpose. To consider the shopping centre building stock as one segment with its own boundaries and trends, the EU FP7 CommONEnergy project set a shopping centre definition1: “A shopping centre is a formation of one or more retail buildings comprising units and ‘communal’ areas, which are planned and managed as a single entity related in its location, size and type of shops to the trade area that it serves.” The European wholesale and retail sector is the big marketplace of Europe, contributing with around 11% of the EU’s GDP2. Therefore, sustainability of the retail sector may significantly contribute to reaching the EU long-term environmental and energy goals. Within the retail sector, shopping centres are of particular interest due to: their structural complexity and multi-stakeholders’ decisional process, their high energy savings and carbon emissions reduction potential, as well as their importance and influence in shopping tendencies and lifestyle. A shopping centre is a building, or a complex of buildings, designed and built to contain many interconnected activities in different areas. Next to public spaces, there are areas related to work spaces, with different use and location and according to the shopping centre type. They have different opening hours and entrances than the shopping centre. Today, in addition to the mere commercial function, a shopping centre responds to several customer needs: it exhibits recreational attractions …publishedVersio