133 research outputs found
Peliosis hepatis. Personal experience and literature review
Peliosis hepatis (PH) is a disease characterized by
multiple and small, blood-filled cysts within the
parenchymatous organs. PH is a very rare disease,
more common in adults, and when it affects the liver, it
comes to the surgeon’s attention only in an extremely
urgent situation after the lesion’s rupture with the
resulting hemoperitoneum. This report describes the
case of a 29-year-old woman affected by recurring
abdominal pain. CT scans showed a hepatic lesion
formed by multiple hypodense areas, which showed
an early acquisition of the contrast during the arterial
phase. Furthermore, it remained isodense with the
remaining parenchyma during the late venous phase.
We decided on performing a liver resection of segment
â…¦ while avoiding a biopsy for safety reasons. The
histopathologic examination confirmed the diagnosis
of focal PH. PH should always be considered in the
differential diagnosis of hepatic lesions. Clinicians
should discuss the possible causes and issues related to
the differential diagnosis in addition to the appropriate
therapeutic approach. The fortuitous finding of a
lesion, potentially compatible with PH, requires elective
surgery with diagnostic and therapeutic intents. The
main aim is to prevent the risk of a sudden bleeding
that, in absence of properly equipped structures, may
have a fatal outcome
Oncoplastic central quadrantectomies
Tumors localized in the central quadrant (centrally located breast tumors) have always represented a challenge for the surgeon because of the critical aesthetical matters related to the nipple-areola complex (NAC). Many years of experience with breast cancer patients treated by using various oncoplastic techniques, has allowed us to develop the modified hemibatwing for the treatment of central breast tumors, where the NAC is involved. Modified hemibatwing-along with the removal of the NAC-is a useful oncoplastic technique and it represents an ideal option for the treatment of central tumors because it assures oncological safety, a reduced surgical timetable and greater aesthetical results
An association of boswellia, betaine and myo-inositol (EumastĂłs) in the treatment of mammographic breast density. A randomized, double-blind study
Mammographic breast density is a recognized risk factor for breast cancer. The causes that lead to the proliferation of the glandular breast tissue and, therefore, to an increase of breast density are still unclear. However, a treatment strategy to reduce the mammary density may bring about very relevant clinical outcomes in breast cancer prevention. Myo-inositol is a six-fold alcohol of cyclohexane, has already been proved to modulate different pathways: inflammatory, metabolic, oxidative and endocrine processes, in a wide array of human diseases, including cancer and the genesis of mammary gland and breast diseases, like fibrosis, as well as metabolic and endocrine cues. Similarly, boswellic acid and betaine (three-methyl glycine) both inhibit inflammation and exert protective effects on breast physiology. Based on this scientific background, we hypothesized that a combination including, boswellic acid, betaine and myo-inositol would be able to reduce breast density working on different pathways.OBJECTIVE: Mammographic
breast density is a recognized risk factor for
breast cancer. The causes that lead to the proliferation
of the glandular breast tissue and,
therefore, to an increase of breast density are
still unclear. However, a treatment strategy to
reduce the mammary density may bring about
very relevant clinical outcomes in breast cancer
prevention.
Myo-inositol is a six-fold alcohol of cyclohexane,
has already been proved to modulate different
pathways: inflammatory, metabolic, oxidative
and endocrine processes, in a wide array of human
diseases, including cancer and the genesis
of mammary gland and breast diseases, like fibrosis,
as well as metabolic and endocrine cues.
Similarly, boswellic acid and betaine (threemethyl
glycine) both inhibit inflammation and exert
protective effects on breast physiology.
Based on this scientific background, we hypothesized
that a combinat ion including,
boswellic acid, betaine and myo-inositol would
be able to reduce breast density working on
different pathways.
PATIENTS AND METHODS: In this study,
seventy-six premenopausal women were randomly
assigned to the placebo and the experimental
drug arms (Eumastós®) for six months.
RESULTS: After 6 months of treatment, statistically
significant difference between the two
groups was recorded on the breast density reduction
(60% vs. 9%), using mammographic as
well as ultrasound examination.
CONCLUSIONS: Preliminary data collected
here with support the starting assumptions,that the association comprising boswellic acid,
betaine and myo-inositol significantly reduces
mammary density, providing the first evidence
for a new and safe approach for the management
of mammographic density treatment
A modified sentinel node and occult lesion localization (SNOLL) technique in non-palpable breast cancer. A pilot study
Background: The spread of mammographic screening programs has allowed an increasing amount of early breast
cancer diagnosis. A modern approach to non-palpable breast lesions requires an accurate intraoperative localization, in
order to achieve a complete surgical resection. In addiction, the assessment of lymph node status is mandatory as it
represents a major prognostic factor in these patients. The aim of this study is to evaluate the reliability of a modified
technical approach using a single nanocolloidal radiotracer to localize both sentinel node and breast occult lesion.
Methods: Twenty-five patients with a single non-palpable breast lesions and clinically negative axilla were enrolled. In the
same day of surgery, patients underwent intratumoral and peritumoral administration of 99mTc-labeled nanocolloid tracer
under sonographic guidance. A lymphoscintigraphy was performed to localize the sentinel lymph node and its cutaneous
projection was marked on the skin in order to guide the surgeon to an optimal incision. During surgery an hand-held
gamma-detection probe was used to select the best surgical access route and to guide localization of both occult breast
lesion and sentinel lymph node. After specimen excision, the surgical field was checked with the gamma-probe to verify
the absence of residual sources of significant radioactivity, thereby ensuring a radical treatment in a single surgical session
and minimizing normal tissue excision.
Results: Both targeted breast lesion and sentinel lymph node were localized and removed at the first attempt in every
patients and histopathological diagnosis of malignancy was confirmed in 25/26 samples. Non-palpable lesions were
included within the surgical margins in all patients and in all samples surgical margins were free from neoplastic infiltration
thus avoiding any further reintervention. Only two patients showed metastatic involvement of sentinel lymph node.
Conclusions: The modified sentinel node and occult lesion localization (SNOLL) technique performed with a single
injection of nanocolloidal radiotracer has shown an excellent intraoperative identification rate of both non-palpable lesion
and sentinel lymph node. This procedure offers, as opposed to standard techniques, an accurate, simple and reliable
approach to the management of non-palpable breast cancer
Rare chondrosarcoma of the breast treated with quadrantectomy instead of mastectomy. A case report
Breast chondrosarcoma is a rare sarcoma that mainly occurs in females >50 years old. To the best of our knowledge, only 16 cases were reported in the literature prior to 2013 and all patients were surgically treated by mastectomy, with or without lymphadenectomy, which was occasionally preceded by neoadjuvant chemotherapy. However, the literature does not report the benefit of mastectomy compared with a more conservative surgery. The present study reports a novel case of extraskeletal chondrosarcoma of the breast. A 63‑year‑old female patient presented with a neoplasm localized in the upper‑outer quadrant of the right breast. The palpable lesion with sharp margins was a firm parenchymatous mass, which was confirmed by ultrasonography and mammography. The patient underwent conservative quadrantectomy instead of mastectomy, followed by post‑surgical chemotherapy. A positron emission tomography scan performed five months subsequent to the surgery revealed no remnants of the disease. The patient underwent a strict clinical and instrumental follow‑up, and two and half years after surgery, there are no signs of recurrent disease. In conclusion, the present case is currently one of the two cases in which a more conservative quadrantectomy was performed, instead of mastectomy. This surgical approach did not lead to metastasis and resulted in a good follow‑up for the patient
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