SJS/TEN 2019: From Science to Translation

Stevens-Johnson syndrome and toxic epidermal necrolysis (SJS/TEN) are potentially life-threatening, immune-mediated adverse reactions characterized by widespread erythema, epidermal necrosis, and detachment of skin and mucosa. Efforts to grow and develop functional international collaborations and a multidisciplinary interactive network focusing on SJS/TEN as an uncommon but high burden disease will be necessary to improve efforts in prevention, early diagnosis and improved acute and long-term management. SJS/TEN 2019: From Science to Translation was a 1.5-day scientific program held April 26-27, 2019, in Vancouver, Canada. The meeting successfully engaged clinicians, researchers, and patients and conducted many productive discussions on research and patient care needs

Impact of clinical phenotypes on management and outcomes in European atrial fibrillation patients: a report from the ESC-EHRA EURObservational Research Programme in AF (EORP-AF) General Long-Term Registry

Background: Epidemiological studies in atrial fibrillation (AF) illustrate that clinical complexity increase the risk of major adverse outcomes. We aimed to describe European AF patients\u2019 clinical phenotypes and analyse the differential clinical course. Methods: We performed a hierarchical cluster analysis based on Ward\u2019s Method and Squared Euclidean Distance using 22 clinical binary variables, identifying the optimal number of clusters. We investigated differences in clinical management, use of healthcare resources and outcomes in a cohort of European AF patients from a Europe-wide observational registry. Results: A total of 9363 were available for this analysis. We identified three clusters: Cluster 1 (n = 3634; 38.8%) characterized by older patients and prevalent non-cardiac comorbidities; Cluster 2 (n = 2774; 29.6%) characterized by younger patients with low prevalence of comorbidities; Cluster 3 (n = 2955;31.6%) characterized by patients\u2019 prevalent cardiovascular risk factors/comorbidities. Over a mean follow-up of 22.5 months, Cluster 3 had the highest rate of cardiovascular events, all-cause death, and the composite outcome (combining the previous two) compared to Cluster 1 and Cluster 2 (all P <.001). An adjusted Cox regression showed that compared to Cluster 2, Cluster 3 (hazard ratio (HR) 2.87, 95% confidence interval (CI) 2.27\u20133.62; HR 3.42, 95%CI 2.72\u20134.31; HR 2.79, 95%CI 2.32\u20133.35), and Cluster 1 (HR 1.88, 95%CI 1.48\u20132.38; HR 2.50, 95%CI 1.98\u20133.15; HR 2.09, 95%CI 1.74\u20132.51) reported a higher risk for the three outcomes respectively. Conclusions: In European AF patients, three main clusters were identified, differentiated by differential presence of comorbidities. Both non-cardiac and cardiac comorbidities clusters were found to be associated with an increased risk of major adverse outcomes

Distribution of Reinforcing Particles in the Pressure Die Cast AlSi11/20% Sic Composite

A method of pressure die casting of composites with AlSi11 alloy matrix reinforced with 20 vol. % of SiC particles and the analysis of the distribution of particles within the matrix are presented. The composite castings were produced at various values of the piston velocity in the second stage of injection, at diverse intensification pressure values, and various injection gate width values. The distribution of particles over the entire cross-section of the tensile specimen is shown. The index of distribution was determined on the basis of particle count in elementary measuring fields. The regression equation describing the change of the considered index was found as a function of the pressure die casting parameters. The conclusion presents an analysis of the obtained results and their interpretation.Przedstawiono metodykę odlewania ciśnieniowego kompozytów na osnowie stopu AlSi11 zbrojonego 20% udziałem objętościowym cząstek SiC i ich rozmieszczenia w osnowie. Odlewy kompozytowe wykonano przy różnych wielkościach prędkości tłoka w II fazie ruchu, ciśnieniu doprasowania i szerokości szczeliny wlewowej. Przedstawiono rozmieszczenie cząstek SiC na całym przekroju odlewu próbki do badania rozciągania. Na podstawie zliczeń liczby cząstek w elementarnych polach pomiarowych określono wskaźnik ich rozmieszczenia. Obliczono równanie regresji zmiany tego wskaźnika jako funkcję parametrów odlewania ciśnieniowego. W podsumowaniu przedstawiono analizę uzyskanych wyników i ich interpretację

The Influence of Pressure Die Casting Parameters on the Mechanical Properties of AlSi11/10 Vol.% SiC Composite

The paper presents the method of preparing a composite slurry composed of AlSi11 alloy matrix and 10 vol.% of SiC particles, as well as the method of its high-pressure die casting and the measurement results concerning the tensile strength, the yield point, the elongation and hardness of the obtained composite. Composite castings were produced at various values of the piston velocity in the second stage of injection, diverse intensification pressure values, and various injection gate width values. There were found the regression equations describing the change of mechanical properties of the examined composite as a function of pressure die casting process parameters. The conclusion gives the analysis and the interpretation of the obtained results

The influence of pressure die casting parameters on distribution of reinforcing particles in the AlSi11/10% SiC composite

The method of pressure die casting of composites with AlSi11 alloy matrix reinforced with 10 vol. % of SiC particles and the analysis of the distribution of particles within the matrix is presented. The composite castings were produced at various values of the piston velocity in the second stage of injection, at diverse intensification pressure values, and various injection gate width values. The distribution of particles over the entire cross-section of the tensile specimen is shown. The index of distribution was determined on the basis of particle count in elementary measuring fields. The regression equation describing the change of the considered index was found as a function of the pressure die casting parameters. The conclusion presents an analysis of the obtained results and their interpretation

The Influence of Pressure Die Casting Parameters on the Mechanical Properties of AlSi11/10 Vol.% SiC Composite

The paper presents the method of preparing a composite slurry composed of AlSi11 alloy matrix and 10 vol.% of SiC particles, as well as the method of its high-pressure die casting and the measurement results concerning the tensile strength, the yield point, the elongation and hardness of the obtained composite. Composite castings were produced at various values of the piston velocity in the second stage of injection, diverse intensification pressure values, and various injection gate width values. There were found the regression equations describing the change of mechanical properties of the examined composite as a function of pressure die casting process parameters. The conclusion gives the analysis and the interpretation of the obtained results

Tribological Properties of AlSi11-SiCp Composite Castings Produced by Pressure Die Casting Method

The measurement results concerning the abrasive wear of AlSi11-SiC particles composites are presented in paper. The method of preparing a composite slurry composed of AlSi11 alloy matrix and 10, 20% vol.% of SiC particles, as well as the method of its high-pressure die casting was described. Composite slurry was injected into metal mould of cold chamber pressure die cast machine and castings were produced at various values of the piston velocity in the second stage of injection, diverse intensification pressure values, and various injection gate width values. Very good uniform arrangement of SiC particles in volume composite matrix was observed and these results were publicated early in this journal. The kinetics of abrasive wear and correlation with SiC particles arrangement in composite matrix were presented. Better wear resistance of composite was observed in comparison with aluminium alloy. Very strong linear correlation between abrasive wear and particle arrangement was observed. The conclusion gives the analysis and the interpretation of the obtained results

Rozmieszczenie cząstek fazy zbrojącej w odlewanym ciśnieniowo kompozycie AlSi11/20% SiC

A method of pressure die casting of composites with AlSi11 alloy matrix reinforced with 20 vol. % of SiC particles and the analysis of the distribution of particles within the matrix are presented. The composite castings were produced at various values of the piston velocity in the second stage of injection, at diverse intensification pressure values, and various injection gate width values. The distribution of particles over the entire cross-section of the tensile specimen is shown. The index of distribution was determined on the basis of particle count in elementary measuring fields. The regression equation describing the change of the considered index was found as a function of the pressure die casting parameters. The conclusion presents an analysis of the obtained results and their interpretation.Przedstawiono metodykę odlewania ciśnieniowego kompozytów na osnowie stopu AlSi11 zbrojonego 20% udziałem objętościowym cząstek SiC i ich rozmieszczenia w osnowie. Odlewy kompozytowe wykonano przy różnych wielkościach prędkości tłoka w II fazie ruchu, ciśnieniu doprasowania i szerokości szczeliny wlewowej. Przedstawiono rozmieszczenie cząstek SiC na całym przekroju odlewu próbki do badania rozciągania. Na podstawie zliczeń liczby cząstek w elementarnych polach pomiarowych określono wskaźnik ich rozmieszczenia. Obliczono równanie regresji zmiany tego wskaźnika jako funkcję parametrów odlewania ciśnieniowego. W podsumowaniu przedstawiono analizę uzyskanych wyników i ich interpretację