Benzene-1,3-diammonium bis­(pyridine-2,6-dicarboxyl­ato-κ3 O 2,N,O 6)cobaltate(II) penta­hydrate

In the title compound, (C6H10N2)[Co(C7H3NO4)2]·5H2O, the CoII ion is six-coordinated in an N2O4 environment by two pyridine-2,6-dicarboxyl­ate (pydc) ligands, having a distorted octa­hedral geometry. The crystal packing is stabilized by inter­molecular N—H⋯O, O—H⋯O and weak C—H⋯O hydrogen bonds. There are also π–π inter­actions between the pyridine rings of the pydc ligands and between the pydc ligands and the benzene-1,3-diammonium cations, with centroid–centroid distances of 3.4575 (15) and 3.7521 (15) Å

Bis(2-amino-6-methyl­pyridinium) tris­(pyridine-2,6-dicarboxyl­ato)zirconate(IV) dihydrate

In the title compound, (C6H9N2)2[Zr(C7H3NO4)3]·2H2O, the ZrIV atom is nine-coordinated by three pyridine-2,6-dicarboxyl­ate ligands in a distorted tricapped trigonal–prismatic ZrN3O6 environment. The crystal packing is stabilized by inter­molecular N—H⋯O and O—H⋯O hydrogen bonds

Poly[tri-μ2-aqua-(μ3-pyridine-2,4-dicarboxyl­ato-κ4 N,O 2:O 2:O 2′)barium]

In the polymeric title compound, [Ba(C7H3NO4)(H2O)3]n, the BaII ion is ten-coordinated in an NO9 environment by one N atom and three O atoms from three pyridine-2,4-dicarboxyl­ate (pydc) ligands and six water mol­ecules. The μ3-pydc ligands and the bridging water mol­ecules connect the Ba atoms into a layer parallel to (100). The crystal packing is stabilized by O—H⋯O and C—H⋯O hydrogen bonds

Plakoglobin: Role in Tumorigenesis and Metastasis

Plakoglobin (γ-catenin) is a member of the Armadillo family of proteins and a homolog of β-catenin. As a component of both the adherens junctions and desmosomes, plakoglobin plays a pivotal role in the regulation of cell-cell adhesion. Furthermore, similar to β-catenin, plakoglobin is capable of participating in cell signaling. However, unlike β-catenin that has well-documented oncogenic potential through its involvement in the Wnt signaling pathway, plakoglobin generally acts as a tumor/metastasis suppressor. The exact roles that plakoglobin plays during tumorigenesis and metastasis are not clear; however, recent evidence suggests that it may regulate gene expression, cell proliferation, apoptosis, invasion, and migration. In this paper, we describe plakoglobin, its discovery and characterization, its role in regulating cell-cell adhesion, and its signaling capabilities in regulation of tumorigenesis and metastasis

Paraoxonase gene polymorphisms and haplotype analysis in a stroke population

Peer reviewedPublisher PD

Mask Off: Analytic-based Malware Detection By Transfer Learning and Model Personalization

The vulnerability of smartphones to cyberattacks has been a severe concern to users arising from the integrity of installed applications (\textit{apps}). Although applications are to provide legitimate and diversified on-the-go services, harmful and dangerous ones have also uncovered the feasible way to penetrate smartphones for malicious behaviors. Thorough application analysis is key to revealing malicious intent and providing more insights into the application behavior for security risk assessments. Such in-depth analysis motivates employing deep neural networks (DNNs) for a set of features and patterns extracted from applications to facilitate detecting potentially dangerous applications independently. This paper presents an Analytic-based deep neural network, Android Malware detection (ADAM), that employs a fine-grained set of features to train feature-specific DNNs to have consensus on the application labels when their ground truth is unknown. In addition, ADAM leverages the transfer learning technique to obtain its adjustability to new applications across smartphones for recycling the pre-trained model(s) and making them more adaptable by model personalization and federated learning techniques. This adjustability is also assisted by federated learning guards, which protect ADAM against poisoning attacks through model analysis. ADAM relies on a diverse dataset containing more than 153000 applications with over 41000 extracted features for DNNs training. The ADAM's feature-specific DNNs, on average, achieved more than 98% accuracy, resulting in an outstanding performance against data manipulation attacks

Cafeato de metilo butilado: un nuevo antioxidante

A novel caffeic acid derivative, butylated methyl caffeate (BMC), was synthesized via esterification between butylated caffeic acid (BCA) and methanol. Its antioxidant activity was investigated and compared to TBHQ, caffeic acid (CA), methyl caffeate (MC) and BCA through deep-frying, an oven test in oil-in-water emulsions and DPPH radical scavenging. BMC showed the strongest antioxidant activity among the five anti­oxidants in emulsions and its antioxidant activity was almost as strong as BCA in frying. Its soybean oil-water partition coefficient was 9.18 due to its ester and tert-butyl groups, far greater than those of MC (4.82), BCA (2.41), CA (0.84) and TBHQ (3.22). This meant that it was much more soluble in the lipid phase than the other four antioxidants in emulsions. The DPPH radical scavenging activity of BMC was near TBHQ, lower than the other three because of its steric hindrance and less functional phenolic hydroxyl groups compared to others when their masses were the same.Un novedoso derivado del ácido cafeico, el cafeato de metilo butilado (BMC), fue sintetizado mediante esterificación entre el ácido cafeico butilado (BCA) y el metanol. Se investigó su actividad antioxidante y se comparó con TBHQ, ácido cafeico (CA), cafeato de metilo (MC) y BCA mediante pruebas de fritura, pruebas en horno, en emulsiones de aceite en agua y mediante eliminación de radicales DPPH. BMC mostró la mayor actividad antioxidante entre los cinco antioxidantes en emulsiones y tenía una actividad antioxidante casi tan fuerte como la del BCA en fritura. Su coeficiente de partición aceite de soja-agua es de 9.18 debido a sus grupos éster y terc-butilo, mucho mayores que los de MC (4.82), BCA (2.41), CA (0.84) y TBHQ (3.22). Esto significa que es mucho más soluble en la fase lipídica que los otros cuatro antioxidantes cuando está en emulsiones. La actividad de captación de radicales DPPH de BMC fue cercana a la del TBHQ, más baja que las otras tres debido a su impedimento estérico y grupos hidroxilo fenólicos, menos funcionales en comparación con los otros cuando sus masas son iguales

GATA3 somatic mutations are associated with clinicopathological features and expression profile in TCGA breast cancer patients

Acknowledgments This work was mainly conducted in a sabbatical period at the Discipline of Genetics, Faculty of Medicine, Memorial University, St. John’s, Canada (FA), with the financial support from the Mashhad University of Medical Sciences, Mashhad, Iran. Authors gratefully acknowledge the use of data generated by TCGA Research Network (https://www.cancer.gov/tcga). Funding Information: This work was financially supported by Mashhad University of Medical Sciences under grant 931185. Supplementary Information: The online version contains supplementary material available at https://doi. org/10.1038/s41598-020-80680-9.Peer reviewedPublisher PD