The Middlesex University rehabilitation robot

This paper outlines the historical developments of Wheelchair-Mounted Robot Arms (WMRA's) and then focuses on the ongoing research at Middlesex to develop a low-cost aid to daily living for users with high-level quadriplegia. A detailed review is given explaining the design specification. It describes the construction of the robotic device and its control architecture. The prototype robot used several gesture recognition and other input systems. The prototype has been tested on disabled and non-disabled users with positive feedback. They observed that it was easy to use, but issues about speed of operation were resolved after further development. The robot has a payload of greater than 1kg with a maximum reach of 0.7–0.9m. Published by the Taylor & Francis Publishing Group, this publication is one of the only journals to cover the multi-disciplinary area of medical technology research. Currently, research bids are being formulated with the School of Computing Science to continue this research

Intention and motor representation in purposive action

Are there distinct roles for intention and motor representation in explaining the purposiveness of action? Standard accounts of action assign a role to intention but are silent on motor representation. The temptation is to suppose that nothing need be said here because motor representation is either only an enabling condition for purposive action or else merely a variety of intention. This paper provides reasons for resisting that temptation. Some motor representations, like intentions, coordinate actions in virtue of representing outcomes; but, unlike intentions, motor representations cannot feature as premises or conclusions in practical reasoning. This implies that motor representation has a distinctive role in explaining the purposiveness of action. It also gives rise to a problem: were the roles of intention and motor representation entirely independent, this would impair effective action. It is therefore necessary to explain how intentions interlock with motor representations. The solution, we argue, is to recognise that the contents of intentions can be partially determined by the contents of motor representations. Understanding this content-determining relation enables better understanding how intentions relate to actions

Groundwater seepage landscapes from distant and local sources in experiments and on Mars

© 2014 Author(s). Valleys with theater-shaped heads can form due to the seepage of groundwater and as a result of knickpoint (waterfall) erosion generated by overland flow. This ambiguity in the mechanism of formation hampers the interpretation of such valleys on Mars, particularly since there is limited knowledge of material properties. Moreover, the hydrological implications of a groundwater or surface water origin are important for our understanding of the evolution of surface features on Mars, and a quantification of valley morphologies at the landscape scale may provide diagnostic insights on the formative hydrological conditions. However, flow patterns and the resulting landscapes produced by different sources of groundwater are poorly understood. We aim to improve the understanding of the formation of entire valley landscapes through seepage processes from different groundwater sources that will provide a framework of landscape metrics for the interpretation of such systems. We study groundwater seepage from a distant source of groundwater and from infiltration of local precipitation in a series of sandbox experiments and combine our results with previous experiments and observations of the Martian surface. Key results are that groundwater flow piracy acts on valleys fed by a distant groundwater source and results in a sparsely dissected landscape of many small and a few large valleys. In contrast, valleys fed by a local groundwater source, i.e., nearby infiltration, result in a densely dissected landscape. In addition, valleys fed by a distant groundwater source grow towards that source, while valleys with a local source grow in a broad range of directions and have a strong tendency to bifurcate, particularly on flatter surfaces. We consider these results with respect to two Martian cases: Louros Valles shows properties of seepage by a local source of groundwater and Nirgal Vallis shows evidence of a distant source, which we interpret as groundwater flow from Tharsis

The evolutionary state of short-period magnetic white dwarf binaries

We present phase-resolved spectroscopy of two new short-period low accretion rate magnetic binaries, SDSS J125044.42+154957.3 (Porb= 86 min) and SDSS J151415.65+074446.5 (Porb= 89 min). Both systems were previously identified as magnetic white dwarfs from the Zeeman splitting of the Balmer absorption lines in their optical spectra. Their spectral energy distributions exhibit a large near-infrared excess, which we interpret as a combination of cyclotron emission and possibly a late-type companion star. No absorption features from the companion are seen in our optical spectra. We derive the orbital periods from a narrow, variable Hα emission line which we show to originate on the companion star. The high radial velocity amplitude measured in both systems suggests a high orbital inclination, but we find no evidence for eclipses in our data. The two new systems resemble the polar EF Eri in its prolonged low state and also SDSS J121209.31+013627.7, a known magnetic white dwarf plus possible brown dwarf binary, which was also recovered by our method

Evidence of Low-Temperature Superparamagnetism in Mn3O_{3}O_{4}$ Nanoparticle Ensembles

Please refer to the abstract within the main body of the paper

Relationships and events: towards a general theory of reification and truthmaking.

We propose a novel ontological analysis of relations and relationships based on a re-visitation of a classic problem in the practice of knowledge repre- sentation and conceptual modeling, namely relationship reification. Our idea is that a relation holds in virtue of a relationship's existence. Relationships are therefore truthmakers of relations. In this paper we present a general theory or reification and truthmaking, and discuss the interplay between events and rela- tionships, suggesting that relationships are the focus of events, which emerge from the context (the scene) they occur in

A magnetic white dwarf in a detached eclipsing binary

SDSS J030308.35+005444.1 is a close, detached, eclipsing white dwarf plus M dwarf binary which shows a large infrared excess which has been interpreted in terms of a circumbinary dust disc. In this paper, we present optical and near-infrared photometric and spectroscopic data for this system. At optical wavelengths, we observe heated pole caps from the white dwarf caused by accretion of wind material from the main-sequence star on to the white dwarf. At near-infrared wavelengths, we see the eclipse of two poles on the surface of the white dwarf by the main-sequence star indicating that the white dwarf is magnetic. Our spectroscopic observations reveal Zeeman-split emission lines in the hydrogen Balmer series, which we use to measure the magnetic field strength as 8 MG. This measurement indicates that the cyclotron lines are located in the infrared, naturally explaining the infrared excess without the need for a circumbinary dust disc. We also detect magnetically confined material located roughly midway between the two stars. Using measurements of the radial velocity amplitude and rotational broadening of the M star, we constrain the physical parameters of the system, a first for a magnetic white dwarf, and the location of the poles on the surface of the white dwarf. SDSS J030308.35+005444.1 is a pre-cataclysmic variable that will likely evolve into an intermediate polar in ∼1 Gyr

High expression of nicotinamide N-methyltransferase in patients with sporadic Alzheimer’s disease

We have previously shown that the expression of nicotinamide N-methyltransferase (NNMT) is significantly increased in the brains of patients who have died of Parkinson’s disease (PD). In this study, we have compared the expression of NNMT in post-mortem medial temporal lobe, hippocampus and cerebellum of 10 Alzheimer’s disease (AD) and 9 non-disease control subjects using a combination of quantitative Western blotting, immunohistochemistry and dual-label confocal microscopy coupled with quantitative analysis of colocalisation. NNMT was detected as a single protein of 29 kDa in both AD and non-disease control brains, which was significantly increased in AD medial temporal lobe compared to non-disease controls (7.5-fold, P < 0.026). There was no significant difference in expression in the cerebellum (P = 0.91). NNMT expression in AD medial temporal lobe and hippocampus was present in cholinergic neurones with no glial localisation. Cell-type expression was identical in both non-disease control and AD tissues. These results are the first to show, in a proof-of-concept study using a small patient cohort, that NNMT protein expression is increased in the AD brain and is present in neurones which degenerate in AD. These results suggest that the elevation of NNMT may be a common feature of many neurodegenerative diseases. Confirmation of this overexpression using a larger AD patient cohort will drive the future development of NNMT-targetting therapeutics which may slow or stop the disease pathogenesis, in contrast to current therapies which solely address AD symptoms