8,522 research outputs found
Quantitative Stability and Optimality Conditions in Convex Semi-Infinite and Infinite Programming
This paper concerns parameterized convex infinite (or semi-infinite)
inequality systems whose decision variables run over general
infinite-dimensional Banach (resp. finite-dimensional) spaces and that are
indexed by an arbitrary fixed set T . Parameter perturbations on the right-hand
side of the inequalities are measurable and bounded, and thus the natural
parameter space is . Based on advanced variational analysis, we
derive a precise formula for computing the exact Lipschitzian bound of the
feasible solution map, which involves only the system data, and then show that
this exact bound agrees with the coderivative norm of the aforementioned
mapping. On one hand, in this way we extend to the convex setting the results
of [4] developed in the linear framework under the boundedness assumption on
the system coefficients. On the other hand, in the case when the decision space
is reflexive, we succeed to remove this boundedness assumption in the general
convex case, establishing therefore results new even for linear infinite and
semi-infinite systems. The last part of the paper provides verifiable necessary
optimality conditions for infinite and semi-infinite programs with convex
inequality constraints and general nonsmooth and nonconvex objectives. In this
way we extend the corresponding results of [5] obtained for programs with
linear infinite inequality constraints
Chronic Stress Triggers Expression of Immediate Early Genes and Differentially Affects the Expression of AMPA and NMDA Subunits in Dorsal and Ventral Hippocampus of Rats
Indexación: Web of Science; Scopus.Previous studies in rats have demonstrated that chronic restraint stress triggers anhedonia, depressive-like behaviors, anxiety and a reduction in dendritic spine density in hippocampal neurons. In this study, we compared the effect of repeated stress on the expression of α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) and N-methyl-D-aspartate (NMDA) receptor subunits in dorsal and ventral hippocampus (VH). Adult male Sprague-Dawley rats were randomly divided into control and stressed groups, and were daily restrained in their motion (2.5 h/day) during 14 days. We found that chronic stress promotes an increase in c-Fos mRNA levels in both hippocampal areas, although it was observed a reduction in the immunoreactivity at pyramidal cell layer. Furthermore, Arc mRNAs levels were increased in both dorsal and VH, accompanied by an increase in Arc immunoreactivity in dendritic hippocampal layers. Furthermore, stress triggered a reduction in PSD-95 and NR1 protein levels in whole extract of dorsal and VH. Moreover, a reduction in NR2A/NR2B ratio was observed only in dorsal pole. In synaptosomal fractions, we detected a rise in NR1 in dorsal hippocampus (DH). By indirect immunofluorescence we found that NR1 subunits rise, especially in neuropil areas of dorsal, but not VH. In relation to AMPA receptor (AMPAR) subunits, chronic stress did not trigger any change, either in dorsal or ventral hippocampal areas. These data suggest that DH is more sensitive than VH to chronic stress exposure, mainly altering the expression of NMDA receptor (NMDAR) subunits, and probably favors changes in the configuration of this receptor that may influence the function of this area.https://www.frontiersin.org/articles/10.3389/fnmol.2017.00244/ful
Short-term memory binding in mild cognitive impairment
We showed that short-term memory (STM) binding is sensitive to sporadic and familial Alzheimer's disease (AD) but is not affected by healthy ageing, chronic depression in the elderly or other forms of dementia. STM binding deficits were also observed in individuals with a genetic susceptibility for AD in the preclinical stages. Hence, we aim to investigate longitudinally individuals with Mild Cognitive Impairment (MCI) using STM binding tasks. Here we report on preliminary cross-sectional results. A comprehensive neuropsychological test battery and a visual STM task were given to 21 MCI patients and 20 controls. The STM task required participants to recognise changes across two consecutive arrays presenting either single features (colour or shape) or feature bindings. The MCI group performed significantly poorer than controls on standard tests of memory, attention and on the binding condition of the STM task, but not on single feature conditions. Performance on the binding task and on standard memory tests did not correlate. Eight MCI patients clearly performed outwith the range of normality in the binding task. However, they did not significantly differ from the other 13 MCI patients in disease severity or demographic and neuropsychological variables. Six patients with binding impairments showed a multiple domain profile whereas ten patients with a preserved binding function showed an amnesic profile [Chi-square = 5.45, p = 0.020]. These results suggest that (1) the binding task is assessing a function different from other memory tests and that (2) STM binding may be differentially impaired in MCI subgroups
Turbulent transport in tokamak plasmas with rotational shear
Nonlinear gyrokinetic simulations have been conducted to investigate
turbulent transport in tokamak plasmas with rotational shear. At sufficiently
large flow shears, linear instabilities are suppressed, but transiently growing
modes drive subcritical turbulence whose amplitude increases with flow shear.
This leads to a local minimum in the heat flux, indicating an optimal E x B
shear value for plasma confinement. Local maxima in the momentum fluxes are
also observed, allowing for the possibility of bifurcations in the E x B shear.
The sensitive dependence of heat flux on temperature gradient is relaxed for
large flow shear values, with the critical temperature gradient increasing at
lower flow shear values. The turbulent Prandtl number is found to be largely
independent of temperature and flow gradients, with a value close to unity.Comment: 4 pages, 5 figures, submitted to PR
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Stress rapidly suppresses in vivo LH pulses and increases activation of RFRP-3 neurons in male mice
Restraint stress is a psychosocial stressor that suppresses reproductive status, including LH pulsatile secretion, but the neuroendocrine mechanisms underlying this inhibition remains unclear. Reproductive neural populations upstream of gonadotropin-releasing hormone (GnRH) neurons, such as kisspeptin, neurokinin B and RFRP-3 (GnIH) neurons, are possible targets for psychosocial stress to inhibit LH pulses, but this has not been well examined, especially in mice in which prior technical limitations prevented assessment of in vivo LH pulse secretion dynamics. Here, we examined whether one-time acute restraint stress alters in vivo LH pulsatility and reproductive neural populations in male mice, and what the time-course is for such alterations. We found that endogenous LH pulses in castrated male mice are robustly and rapidly suppressed by one-time, acute restraint stress, with suppression observed as quickly as 12â18âmin. This rapid LH suppression parallels with increased in vivo corticosterone levels within 15âmin of restraint stress. Although Kiss1, Tac2 and Rfrp gene expression in the hypothalamus did not significantly change after 90 or 180 min restraint stress, arcuate Kiss1 neural activation was significantly decreased after 180âmin. Interestingly, hypothalamic Rfrp neuronal activation was strongly increased at early times after restraint stress initiation, but was attenuated to levels lower than controls by 180âmin of restraint stress. Thus, the male neuroendocrine reproductive axis is quite sensitive to short-term stress exposure, with significantly decreased pulsatile LH secretion and increased hypothalamic Rfrp neuronal activation occurring rapidly, within minutes, and decreased Kiss1 neuronal activation also occurring after longer stress durations
Zero-Turbulence Manifold in a Toroidal Plasma
Sheared toroidal flows can cause bifurcations to zero-turbulent-transport
states in tokamak plasmas. The maximum temperature gradients that can be
reached are limited by subcritical turbulence driven by the parallel velocity
gradient. Here it is shown that q/\epsilon (magnetic field pitch/inverse aspect
ratio) is a critical control parameter for sheared tokamak turbulence. By
reducing q/\epsilon, far higher temperature gradients can be achieved without
triggering turbulence, in some instances comparable to those found
experimentally in transport barriers. The zero-turbulence manifold is mapped
out, in the zero-magnetic-shear limit, over the parameter space (\gamma_E,
q/\epsilon, R/L_T), where \gamma_E is the perpendicular flow shear and R/L_T is
the normalised inverse temperature gradient scale. The extent to which it can
be constructed from linear theory is discussed.Comment: 5 Pages, 4 Figures, Submitted to PR
Transport Bifurcation in a Rotating Tokamak Plasma
The effect of flow shear on turbulent transport in tokamaks is studied
numerically in the experimentally relevant limit of zero magnetic shear. It is
found that the plasma is linearly stable for all non-zero flow shear values,
but that subcritical turbulence can be sustained nonlinearly at a wide range of
temperature gradients. Flow shear increases the nonlinear temperature gradient
threshold for turbulence but also increases the sensitivity of the heat flux to
changes in the temperature gradient, except over a small range near the
threshold where the sensitivity is decreased. A bifurcation in the equilibrium
gradients is found: for a given input of heat, it is possible, by varying the
applied torque, to trigger a transition to significantly higher temperature and
flow gradients.Comment: 4 pages, 4 figures, submitted to PR
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