Diet of oceanic loggerhead sea turtles (Caretta caretta) in the central North Pacific

Diet analysis of 52 loggerhead sea turtles (Caretta caretta) collected as bycatch from 1990 to 1992 in the high-seas driftnet fishery operating between lat. 29.5°N and 43°N and between long. 150°E and 154°W demonstrated that these turtles fed predominately at the surface; few deeper water prey items were present in their stomachs. The turtles ranged in size from 13.5 to 74.0 cm curved carapace length. Whole turtles (n =10) and excised stomachs (n= 42) were frozen and transported to a laboratory for analysis of major faunal components. Neustonic species accounted for four of the five most common prey taxa. The most common prey items were Janthina spp. (Gastropoda); Carinaria cithara Benson 1835 (Heteropoda); a chondrophore, Velella velella (Hydrodia); Lepas spp. (Cirripedia), Planes spp. (Decapoda: Grapsidae), and pyrosomas (Pyrosoma spp.)

Analysis and Evaluation of Participation by Prescibers and Dispensers in the Maine State Prescription Monitoring Program

As part of a Department of Justice, U.S. Attorneys Office grant for the analysis and evaluation of participation in the Prescription Monitoring Program (PMP), the Margaret Chase Smith Policy Center mapped and analyzed spatial patterns of prescriber and pharmacy locations as well as PMP participation, and conducted a survey of licensed prescribers and dispensers of controlled substances in Maine. The PMP, implemented beginning July 1, 2004, monitors all drugs in Schedules II, II, and IV, and any pharmacy that is licensed to dispense prescriptions in or into the state of Maine is required by law to report to the program. Prescribers receive automatic reports from the system about patients who exceed a threshold level of activity: prescribers, dispensers, or prescriptions. In addition, prescribers and pharmacists are encouraged to sign up to use the online system that allows them to check patient activity; participation is voluntary. Not all dispensing is tracked. Hospital inpatient dispensing data and data from veterinarians are not collected. Clinics that offer methadone assisted therapy for addictions do not participate. On January 5, 2009, the PMP opened a new web portal for their online system and participants were asked to re-enroll. As of June 9, 2009, 149 Data Submitters are registered to submit data for 403 pharmacies; and 1,197 Prescribers and 138 Dispensers of controlled substances in Maine are currently registered with the service to access online information on their own patients

Awaking the vacuum in relativistic stars

Void of any inherent structure in classical physics, the vacuum has revealed to be incredibly crowded with all sorts of processes in relativistic quantum physics. Yet, its direct effects are usually so subtle that its structure remains almost as evasive as in classical physics. Here, in contrast, we report on the discovery of a novel effect according to which the vacuum is compelled to play an unexpected central role in an astrophysical context. We show that the formation of relativistic stars may lead the vacuum energy density of a quantum field to an exponential growth. The vacuum-driven evolution which would then follow may lead to unexpected implications for astrophysics, while the observation of stable neutron-star configurations may teach us much on the field content of our Universe.Comment: To appear in Phys. Rev. Let

Cosmology with a long range repulsive force

We consider a class of cosmological models in which the universe is filled with a (non-electric) charge density that repels itself by means of a force carried by a vector boson with a tiny mass. When the vector's mass depends upon other fields, the repulsive interaction gives rise to an electromagnetic barrier which prevents these fields from driving the mass to zero. This can modify the cosmology dramatically. We present a very simple realization of this idea in which the vector's mass arises from a scalar field. The electromagnetic barrier prevents this field from rolling down its potential and thereby leads to accelerated expansion.Comment: 15 pages, 8 figures, LaTeX (version accepted for publication in PRD). 3 new figures, extended discussion of observational consequence

TSPO interacts with VDAC1 and triggers a ROS-mediated inhibition of mitochondrial quality control

The 18-kDa TSPO (translocator protein) localizes on the outer mitochondrial membrane (OMM) and participates in cholesterol transport. Here, we report that TSPO inhibits mitochondrial autophagy downstream of the PINK1-PARK2 pathway, preventing essential ubiquitination of proteins. TSPO abolishes mitochondrial relocation of SQSTM1/p62 (sequestosome 1), and consequently that of the autophagic marker LC3 (microtubule-associated protein 1 light chain 3), thus leading to an accumulation of dysfunctional mitochondria, altering the appearance of the network. Independent of cholesterol regulation, the modulation of mitophagy by TSPO is instead dependent on VDAC1 (voltage-dependent anion channel 1), to which TSPO binds, reducing mitochondrial coupling and promoting an overproduction of reactive oxygen species (ROS) that counteracts PARK2-mediated ubiquitination of proteins. These data identify TSPO as a novel element in the regulation of mitochondrial quality control by autophagy, and demonstrate the importance for cell homeostasis of its expression ratio with VDAC1

Transcript-indexed ATAC-seq for precision immune profiling.

T cells create vast amounts of diversity in the genes that encode their T cell receptors (TCRs), which enables individual clones to recognize specific peptide-major histocompatibility complex (MHC) ligands. Here we combined sequencing of the TCR-encoding genes with assay for transposase-accessible chromatin with sequencing (ATAC-seq) analysis at the single-cell level to provide information on the TCR specificity and epigenomic state of individual T cells. By using this approach, termed transcript-indexed ATAC-seq (T-ATAC-seq), we identified epigenomic signatures in immortalized leukemic T cells, primary human T cells from healthy volunteers and primary leukemic T cells from patient samples. In peripheral blood CD4+ T cells from healthy individuals, we identified cis and trans regulators of naive and memory T cell states and found substantial heterogeneity in surface-marker-defined T cell populations. In patients with a leukemic form of cutaneous T cell lymphoma, T-ATAC-seq enabled identification of leukemic and nonleukemic regulatory pathways in T cells from the same individual by allowing separation of the signals that arose from the malignant clone from the background T cell noise. Thus, T-ATAC-seq is a new tool that enables analysis of epigenomic landscapes in clonal T cells and should be valuable for studies of T cell malignancy, immunity and immunotherapy

Analysis and Perspective from the Complex Aerospace Systems Exchange (CASE) 2013

NASA Langley Research Center embedded four rapporteurs at the Complex Aerospace Systems Exchange (CASE) held in August 2013 with the objective to capture the essence of the conference presentations and discussions. CASE was established to provide a discussion forum among chief engineers, program managers, and systems engineers on challenges in the engineering of complex aerospace systems. The meeting consists of invited presentations and panels from industry, academia, and government followed by discussions among attendees. This report presents the major and reoccurring themes captured throughout the meeting and provides analysis and insights to further the CASE mission