1,821 research outputs found
Intrinsic decoherence and classical-quantum correspondence in two coupled delta-kicked rotors
We show that classical-quantum correspondence of center of mass motion in two
coupled delta-kicked rotors can be obtained from intrinsic decoherence of the
system itself which occurs due to the entanglement of the center of mass motion
to the internal degree of freedom without coupling to external environment
The Importance of Hydration in Wound Healing: Reinvigorating the clinical perspective
Balancing skin hydration levels is important as any disruption in skin integrity will result in disturbance of the dermal water balance. The discovery that a moist wound healing environment actively supports the healing response when compared to a dry environment highlights the importance of water and good hydration levels for optimal wound healing.
The benefits of âwetâ or âhyper-hydratedâ wound healing appears to offer benefits that are similar to those offered by moist wound healing over wounds healing in a dry environment. This suggests that the presence of free water itself during wound healing may not be detrimental to healing but that any adverse effects of wound fluid on tissues is more likely related to the biological components contained within chronic wound exudate (e.g. elevated protease levels).
Appropriate dressings applied to wounds must be able to absorb not only the exudate but also retain this excess fluid together with its protease solutes while concurrently preventing desiccation. This is particularly important in the case of chronic wounds where peri-wound skin barrier properties are compromised and there is increased permeation across the injured skin barrier. This review discusses the importance of appropriate levels of hydration in skin with a particular focus on the need for optimal hydration levels for effective healing
The effect of psycho-motor play on motor and body perception competence for young children with developmental delays
This paper aims to describe how psycho-motor play advances motor competence and body perception, by helping to shape a positive
self-image and activate movement. The participants were 4-7 year-old children with developmental delays who attended an inclusive
nursery school. The measurement tools used for the pre-test and post-tests were the Mot 4-6 test, the Perception/Motor Competence
Test and the Psycho-Educational Profile. The children participated in a six week programme in which they were exposed to various
pieces of play equipment. For the data analysis, the total result of the childrenâs performance was averaged and statistical significance
with the t-test and Wilcoxon-test used to determine the difference between pre and post programme scores. The following results were
obtained: Firstly, psycho-motor play was effective in the improvement of balance, postural control, and the coordination in the motor
competence of Young Children with Developmental Delays (YCDD). Secondly, psycho-motor play was effective for the improvement of
body scheme (a component of body perception) and spatial orientation.http://www.otasa.org.za/otasa_journal/index.htmlnf201
Wound healing and hyper-hydration - a counter intuitive model
Winters seminal work in the 1960s relating to providing an optimal level of moisture to aid wound healing (granulation and re-epithelialisation) has been the single most effective advance in wound care over many decades. As such the development of advanced wound dressings that manage the fluidic wound environment have provided significant benefits in terms of healing to both patient and clinician. Although moist wound healing provides the guiding management principle confusion may arise between what is deemed to be an adequate level of tissue hydration and the risk of developing maceration. In addition, the counter-intuitive model âhyper-hydrationâ of tissue appears to frustrate the moist wound healing approach and advocate a course of intervention whereby tissue is hydrated beyond what is a normally acceptable therapeutic level. This paper discusses tissue hydration, the cause and effect of maceration and distinguishes these from hyper-hydration of tissue. The rationale is to provide the clinician with a knowledge base that allows optimisation of treatment and outcomes and explains the reasoning behind wound healing using hyper-hydration
Structural and magnetic properties of Fe/ZnSe(001) interfaces
We have performed first principles electronic structure calculations to
investigate the structural and magnetic properties of Fe/ZnSe(001) interfaces.
Calculations involving full geometry optimizations have been carried out for a
broad range of thickness of Fe layers(0.5 monolayer to 10 monolayers) on top of
a ZnSe(001) substrate. Both Zn and Se terminated interfaces have been explored.
Total energy calculations show that Se segregates at the surface which is in
agreement with recent experiments.
For both Zn and Se terminations, the interface Fe magnetic moments are higher
than the bulk bcc Fe moment.
We have also investigated the effect of adding Fe atoms on top of a
reconstructed ZnSe surface to explore the role of reconstruction of
semiconductor surfaces in determining properties of metal-semiconductor
interfaces. Fe breaks the Se dimer bond formed for a Se-rich (2x1)
reconstructed surface. Finally, we looked at the reverse growth i.e. growth of
Zn and Se atoms on a bcc Fe(001) substrate to investigate the properties of the
second interface of a magnetotunnel junction. The results are in good agreement
with the theoretical and experimental results, wherever available.Comment: 7 pages, 8 figures, accepted for publication in PR
Physical tests for Random Numbers in Simulations
We propose three physical tests to measure correlations in random numbers
used in Monte Carlo simulations. The first test uses autocorrelation times of
certain physical quantities when the Ising model is simulated with the Wolff
algorithm. The second test is based on random walks, and the third on blocks of
n successive numbers. We apply the tests to show that recent errors in high
precision simulations using generalized feedback shift register algorithms are
due to short range correlations in random number sequences. We also determine
the length of these correlations.Comment: 16 pages, Post Script file, HU-TFT-94-
Brane Decay of a (4+n)-Dimensional Rotating Black Hole. III: spin-1/2 particles
In this work, we have continued the study of the Hawking radiation on the
brane from a higher-dimensional rotating black hole by investigating the
emission of fermionic modes. A comprehensive analysis is performed that leads
to the particle, power and angular momentum emission rates, and sheds light on
their dependence on fundamental parameters of the theory, such as the spacetime
dimension and angular momentum of the black hole. In addition, the angular
distribution of the emitted modes, in terms of the number of particles and
energy, is thoroughly studied. Our results are valid for arbitrary values of
the energy of the emitted particles, dimension of spacetime and angular
momentum of the black hole, and complement previous results on the emission of
brane-localised scalars and gauge bosons.Comment: Latex file, JHEP style, 34 pages, 16 figures Energy range in plots
increased, minor changes, version published in JHE
Current reversal with type-I intermittency in deterministic inertia ratchets
The intermittency is investigated when the current reversal occurs in a
deterministic inertia ratchet system. To determine which type the intermittency
belongs to, we obtain the return map of velocities of particle using
stroboscopic recording, and numerically calculate the distribution of average
laminar length . The distribution follows the scaling law of , the characteristic relation of type-I
intermittency.Comment: 4 pages, 7 figure
Dose-linearity of the pharmacokinetics of an intravenous [C-14]midazolam microdose in children
Aims Drug disposition in children may vary from adults due to age-related variation in drug metabolism. Microdose studies present an innovation to study pharmacokinetics (PK) in paediatrics; however, they should be used only when the PK is dose linear. We aimed to assess dose linearity of a [C-14]midazolam microdose, by comparing the PK of an intravenous (IV) microtracer (a microdose given simultaneously with a therapeutic midazolam dose), with the PK of a single isolated microdose. Methods Preterm to 2-year-old infants admitted to the intensive care unit received [C-14]midazolam IV as a microtracer or microdose, followed by dense blood sampling up to 36 hours. Plasma concentrations of [C-14]midazolam and [C-14]1-hydroxy-midazolam were determined by accelerator mass spectrometry. Noncompartmental PK analysis was performed and a population PK model was developed. Results Of 15 infants (median gestational age 39.4 [range 23.9-41.4] weeks, postnatal age 11.4 [0.6-49.1] weeks), 6 received a microtracer and 9 a microdose of [C-14]midazolam (111 Bq kg(-1); 37.6 ng kg(-1)). In a 2-compartment PK model, bodyweight was the most significant covariate for volume of distribution. There was no statistically significant difference in any PK parameter between the microdose and microtracer, nor in the area under curve ratio [C-14]1-OH-midazolam/[C-14]midazolam, showing the PK of midazolam to be linear within the range of the therapeutic and microdoses. Conclusion Our data support the dose linearity of the PK of an IV [C-14]midazolam microdose in children. Hence, a [C-14]midazolam microdosing approach may be used as an alternative to a therapeutic dose of midazolam to study developmental changes in hepatic CYP3A activity in young children
Dose-linearity of the pharmacokinetics of an intravenous [C-14]midazolam microdose in children
Aims Drug disposition in children may vary from adults due to age-related variation in drug metabolism. Microdose studies present an innovation to study pharmacokinetics (PK) in paediatrics; however, they should be used only when the PK is dose linear. We aimed to assess dose linearity of a [C-14]midazolam microdose, by comparing the PK of an intravenous (IV) microtracer (a microdose given simultaneously with a therapeutic midazolam dose), with the PK of a single isolated microdose. Methods Preterm to 2-year-old infants admitted to the intensive care unit received [C-14]midazolam IV as a microtracer or microdose, followed by dense blood sampling up to 36 hours. Plasma concentrations of [C-14]midazolam and [C-14]1-hydroxy-midazolam were determined by accelerator mass spectrometry. Noncompartmental PK analysis was performed and a population PK model was developed. Results Of 15 infants (median gestational age 39.4 [range 23.9-41.4] weeks, postnatal age 11.4 [0.6-49.1] weeks), 6 received a microtracer and 9 a microdose of [C-14]midazolam (111 Bq kg(-1); 37.6 ng kg(-1)). In a 2-compartment PK model, bodyweight was the most significant covariate for volume of distribution. There was no statistically significant difference in any PK parameter between the microdose and microtracer, nor in the area under curve ratio [C-14]1-OH-midazolam/[C-14]midazolam, showing the PK of midazolam to be linear within the range of the therapeutic and microdoses. Conclusion Our data support the dose linearity of the PK of an IV [C-14]midazolam microdose in children. Hence, a [C-14]midazolam microdosing approach may be used as an alternative to a therapeutic dose of midazolam to study developmental changes in hepatic CYP3A activity in young children
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