Feeding and Swallowing Development in Children

The feeding and swallowing developments are involved in maturation of anatomy, food textures, and utensils. As children grow, the dependence of feeding moves to self-feeding. Understanding and educating individuals about feeding and swallowing development is critical. The knowledge of feeding and swallowing development can help parents support nutrition and growth in their children by learning timelines and normal feeding and swallowing expectations. This project is to provide clinical resources in order to assist in providing proper care for patients, recognizing signs demonstrating difficulty swallowing, and implementing appropriate self-feeding and consistency development timetables. Caregivers and clinicians will benefit from this information

Enhancing Quality of Life for Individuals with Dementia through a Virtual OT Based Equine-Assisted Activities Program

Individuals living with dementia typically experience progressive, cognitive, and functional decline which limits their ability to communicate and fully perform activities (Pimouguet el al., 2019). Horses have been shown to benefit individuals with dementia by improving well-being, physical health, functional capacity, and social relationships (Fields et. al., 2019). A 6-week OT based virtual equine-assisted activities program was conducted to determine if participation in equine-assisted activities could improve the quality of life of individuals with dementia. Outcomes of the program resulted in improvements in mood, energy level, engagement, communication, memory, socialization, and overall quality of life. FromSubjectReceivedSizeCategoriesLauren FearnAbstract for Poster7:11 PM26 KBhttps://soar.usa.edu/otdcapstonesfall2020/1007/thumbnail.jp

Skeletal muscle contractile function in heart failure with reduced ejection fraction - A focus on nitric oxide

Despite advances over the past few decades, heart failure with reduced ejection fraction (HFrEF) remains not only a mortal but a disabling disease. Indeed, the New York Heart Association classification of HFrEF severity is based on how much exercise a patient can perform. Moreover, exercise capacity-both aerobic exercise performance and muscle power-are intimately linked with survival in patients with HFrEF. This review will highlight the pathologic changes in skeletal muscle in HFrEF that are related to impaired exercise performance. Next, it will discuss the key role that impaired nitric oxide (NO) bioavailability plays in HFrEF skeletal muscle pathology. Lastly, it will discuss intriguing new data suggesting that the inorganic nitrate \u27enterosalivary pathway\u27 may be leveraged to increase NO bioavailability via ingestion of inorganic nitrate. This ingestion of inorganic nitrate has several advantages over organic nitrate (e.g., nitroglycerin) and the endogenous nitric oxide synthase pathway. Moreover, inorganic nitrate has been shown to improve exercise performance: both muscle power and aerobic capacity, in some recent small but well-controlled, cross-over studies in patients with HFrEF. Given the critical importance of better exercise performance for the amelioration of disability as well as its links with improved outcomes in patients with HFrEF, further studies of inorganic nitrate as a potential novel treatment is critical

“See, I’m not racist!”: Aversive Racism, Peer Pressure, and Blaming Adolescents

Abstract This study examined how peer pressure influences participant’s attribution of blame to Black or White youth committing a crime. Participants read one of four scenarios in which a Black or White male (Kevin), who was or was not under peer pressure, stole a bicycle. To measure the amount of blame participants assigned to the adolescent, they completed a blame attribution inventory. Participants also completed a personality scale to measure their perceptions of the adolescent’s personal characteristics. To avoid being perceived as prejudiced, the researchers predicted participants would blame the White adolescent more than the Black adolescent for stealing the bicycle. Additionally, the researchers predicted that participants would blame the adolescent under peer pressure less than the adolescent not under peer pressure, regardless of race. Finally, the researchers hypothesized that participants would blame the Black adolescent less than the White adolescent in the presence of peer pressure. As predicted, participants blamed the White adolescent more than the Black adolescent, regardless of peer pressure and blamed the adolescent less when under peer pressure, regardless of race. Additionally, in the peer pressure condition, the White adolescent was blamed more than the Black adolescent. There was no interaction between the adolescent’s race and peer pressure

Measuring Individual Disaster Recovery: A Socioecological Framework

Background: Disaster recovery is a complex phenomenon. Too often, recovery is measured in singular fashion, such as quantifying rebuilt infrastructure or lifelines, without taking in to account the affected population's individual and community recovery. A comprehensive framework is needed that encompasses a much broader and far-reaching construct with multiple underlying dimensions and numerous causal pathways; without the consideration of a comprehensive framework that investigates relationships between these factors, an accurate measurement of recovery may not be valid. This study proposes a model that encapsulates these ideas into a single framework, the Socio-Ecological Model of Recovery. Methods: Using confirmatory factor analysis, an operational measure of recovery was developed and validated using the five measures of housing stability, economic stability, physical health, mental health, and social role adaptation. The data were drawn from a sample of displaced households following Hurricane Katrina. Measures of psychological strength, risk, disaster exposure, neighborhood contextual effects, and formal and informal help were modeled to examine their direct and indirect effects on recovery using a structural equation model. Findings: All five elements of the recovery measure were positively correlated with a latent measure of recovery, although mental health and social role adaptation displayed the strongest associations. An individual's psychological strength had the greatest association with positive recovery, followed by having a household income greater than $20 000 and having informal social support. Those factors most strongly associated with an absence of recovery included the time displaced since the hurricane, being disabled, and living in a community with substantial social disorder. Discussion: The socio-ecological framework provides a robust means for measuring recovery, and for testing those factors associated with the presence or absence of recovery

Identification of a transporter complex responsible for the cytosolic entry of nitrogen-containing bisphosphonates

Nitrogen-containing-bisphosphonates (N-BPs) are widely prescribed to treat osteoporosis and other bone-related diseases. Although previous studies established that N-BPs function by inhibiting the mevalonate pathway in osteoclasts, the mechanism by which N-BPs enter the cytosol from the extracellular space to reach their molecular target is not understood. Here we implemented a CRISPRi-mediated genome-wide screen and identified SLC37A3 (solute carrier family 37 member A3) as a gene required for the action of N-BPs in mammalian cells. We observed that SLC37A3 forms a complex with ATRAID (all-trans retinoic acid-induced differentiation factor), a previously identified genetic target of N-BPs. SLC37A3 and ATRAID localize to lysosomes and are required for releasing N-BP molecules that have trafficked to lysosomes through fluid-phase endocytosis into the cytosol. Our results elucidate the route by which N-BPs are delivered to their molecular target, addressing a key aspect of the mechanism of action of N-BPs that may have significant clinical relevance

The effects of human activity on the occupancy of Tamias striatus in the University of Michigan Biostation.

General EcologyThe occupancy of Tamias striatus, the eastern chipmunk, was measured in an area dominated by human structures as well as in a less-traversed deciduous forest at the University of Michigan Biostation on Douglas Lake. Habitat variables such as tree species composition, downed woody debris, above ground biomass, canopy coverage, leaf litter, and basal area were measured in fourteen locations at two chosen sites in order to test the assumption of no difference in forest conditions. It was found that chipmunk occupancy was higher in the area dominated by human structures while occupancy was lower in the less-traversed deciduous forest. However, as some aspects of the environment were significantly different, it was unclear whether the difference in occupancy was the result of physical environment or man-made structures.http://deepblue.lib.umich.edu/bitstream/2027.42/85747/1/Hacias_Miller_Park_2011.pd

Static and Dynamic Autonomic Response with Increasing Nausea Perception

Background—Nausea is a commonly occurring symptom typified by epigastric discomfort with urge to vomit. The relationship between autonomic nervous system (ANS) outflow and increasing nausea perception is not fully understood. Methods—Our study employed a nauseogenic visual stimulus (horizontally translating stripes) while 17 female subjects freely rated transitions in nausea level and autonomic outflow was measured (heart rate, HR, heart rate variability, HRV, skin conductance response, SCR, respiratory rate). We also adopted a recent approach to continuous high frequency (HF) HRV estimation to evaluate dynamic cardiovagal modulation. Results—HR increased from baseline for all increasing nausea transitions, especially transition to strong nausea (15.0±11.4 bpm), but decreased (−6.6±4.6 bpm) once the visual stimulus ceased. SCR also increased for all increasing nausea transitions, especially transition to strong nausea (1.76±1.68 μS), but continued to increase (0.52 ± 0.65 μS) once visual stimulation ceased. LF/HF HRV increased following transition to moderate (1.54±2.11 a.u.) and strong (2.57±3.49 a.u.) nausea, suggesting a sympathetic shift in sympathovagal balance. However, dynamic HF HRV suggested that bursts of cardiovagal modulation precede transitions to higher nausea, perhaps influencing subjects to rate higher levels of nausea. No significant change in respiration rate was found. Conclusions—Our results suggest that increasing nausea perception is associated with both increased sympathetic and decreased parasympathetic ANS modulation. These findings corroborate past ANS studies of nausea, applying percept-linked analyses and dynamic estimation of cardiovagal modulation in response to nausea.National Institutes of Health (U.S.) (Grant R01-HL084502)National Institutes of Health (U.S.) (Grant R01-DA015644)National Institutes of Health (U.S.) (Grant DP1-OD003646)National Institutes of Health (U.S.) (Grant K01-AT002166)National Institutes of Health (U.S.) (Grant P01-AT002048)National Institutes of Health (U.S.) (Grant F05-AT003770)National Institutes of Health (U.S.) (Grant K23-DK069614)National Center for Research Resources (U.S.) (P41RR14075)National Center for Research Resources (U.S.) (CRC 1 UL1 RR025758-01)Mental Illness and Neuroscience Discovery (MIND) InstituteInternational Foundation of Functional Gastrointestinal DisordersInstitute of Information Technology Advancement (South Korea)Institute of Information Technology Advancement (South Korea) (Korea IITA- 2008-(C1090-0801-0002)

Indices of Body Composition and Repeatability of Residual Feed Intake in Growing Columbia Ewes Fed the Same Diet

Residual feed intake (RFI), an efficiency measurement based upon the difference in expected and actual feed intake, is used to improve production efficiency of livestock. The purpose of this study was to evaluate the repeatability of ewe RFI measured for two consecutive years, and to investigate the relationship between indices of body composition in yearling ewes and RFI. Two trials, using the same Columbia ewe lambs (n = 17) were conducted in consecutive years (2014, 2015) using the same diet. RFI was calculated for each ewe each year. RFI did not differ (P = 0.77) between years. Each year, ewes were separated into RFI classes (LOW (efficient); MOD (average); HIGH (inefficient)). In 2014, ewe lamb performance did not differ among classes (P > 0.3). In 2015, dry matter intake was greater for HIGH ewes (P < 0.0002). Ribeye area (REA; cm2) and backfat thickness (BF; cm) were measured by ultrasound on day 0 (start of trial), 17, and 45 (end of trial) in 2015 and used to calculate estimates of final body composition. RFI classification did not affect REA or BF (P > 0.25). There was a trend for whole-body muscle mass to differ among RFI classes (P = 0.09), but no other body composition estimates were affected. Results suggest that RFI is repeatable; however, indices of body composition seem to be independent of RFI in Columbia ewes fed the same diet under similar conditions