Life in the LGBTQ+ Community: Protective Factors Against Depression in the Community and in Everyday Life

Abstract In this study, we examined potential protective factors against depression in the LGBTQ+ community by determining whether outness, self-esteem, perceived social support, life meaning, courage to challenge or resilience/hardiness, life satisfaction, and hope were correlated with less depression. There were 149 participants in the study, 38 of whom identified as members of the LGBTQ+ community, and 107 of whom identified as heterosexual. Participants completed an online survey that took approximately 30 minutes. It was predicted that protective factors would be negatively related to depression. Results of both correlation and regression analyses revealed no significant relations between protective factors and depression. In a post-hoc analysis, the correlations between these factors in the heterosexual participants were statistically significant. Protective factors may be less prevalent or less directly helpful in the LGBTQ+ minority community than they are in the heterosexual majority. In addition, LGBTQ+ participants reported significantly higher levels of depression than the heterosexual participants. Thus, these findings indicate that there are significantly less protective factors present in the lives of LGBTQ+ persons than there are in their heterosexual counterparts

The Role of Emotional Expression on Person Identity Recognition

Facial information concerning person identity and emotional expression is vital to human social interaction, and therefore, we find it beneficial to remember the faces we see. Little is known, however, about whether emotional expressions facilitate or inhibit recognition for person identity. The present studies examined the role of emotional expression on person identity recognition by manipulating whether such information was presented at encoding (i.e., initial perception of the actor) or at recognition (i.e., later memory for the actor). In Experiment 1, participants recognized more actors displaying an angry rather than a happy expression, when they initially saw actors display a neutral expression. Thus, angry rather than happy expressions facilitated recognition memory for person identity. Experiment 2 replicated and extended this finding. Participants recognized more actors displaying a surprised rather than a disgusted, a fearful, a happy or a sad expression, when they initially saw actors display a neutral expression. Furthermore, participants recognized actors displaying a neutral expression, when they initially saw actors display a surprised or a happy expression rather than a disgusted expression. Thus, surprised and angry expressions facilitated recognition memory for person identity, whereas surprised and happy expressions facilitated encoding of person identity. These results have implications not only for basic research concerning cognitive models of face perception (e.g., Bruce & Young, 1986) and evolutionary theories of emotion but also for refinement of methodologies used in the criminal justice system for eyewitness testimony

Exploring the Effects of Financial Strain on Organizational Commitment and Occupational Commitment

Financial strain is defined as an individual’s perception of economic stress and/or lack of resources (Adams et al., 2016). Although it has been linked to a multitude of negative well-being outcomes (Son & Wilson, 2015), there is little research regarding its impact on work-related attitudes, including organizational and occupational commitment. Several studies have found that financially-related variables, such as income, pay satisfaction, and extrinsic organizational rewards are positively related to organizational commitment (Cohen and Lowenberg, 1990; Mathieu and Zajac, 1990; Malhotra et al., 2007). Though occupational commitment and organizational commitment tend to be positively related (Lee et al., 2000), less research has focused on the relationship between occupational commitment and extrinsic rewards. As commitment and turnover or intent to turnover can often stem from job stressors (Jha, 2009), there is likely a relationship between financial strain, which serves as a source of stress, and both organizational and occupational commitment. In the present study, we examined relationships between financial strain and four types of commitment (affective organizational, continuance organizational, affective occupational, and continuance organizational). Data was gathered using an online survey from early career professionals who had graduated college in the past 10 years. Respondents received a $5 gift card for participating, along with entry into a raffle for one of several$50 gift cards. The final sample of 255 respondents was composed more heavily of women (59.4%) and was predominately White (59%). Hierarchical linear regression analyses were used to test our hypotheses, controlling for age, tenure, occupational tenure, and negative affect. Financial strain had a significant negative relationship with affective organizational commitment, b = -.25, p = .001, 〖sr〗^2 = 4.2% and a significant positive relationship with continuance organizational commitment, b = .31, p \u3c .001, 〖sr〗^2 = 8.3%. Financial strain also had a significant negative relationship with affective occupational commitment, b = -.14, p = .04, 〖sr〗^2 = 1.6% and a significant positive relationship with continuance occupational commitment, b = .27, p \u3c .001, 〖sr〗^2 = 8.6%. These findings suggest that financial strain may impact employee’s commitment to their organization and occupation. This knowledge can help provide employers a better understanding of the employee’s experience, especially for early career professionals. It may also encourage organizations to curate benefits and resources that assist in alleviating employees’ financial strain

Layered Deposits of Arabia Terra and Meridiani Planum: Keys to the Habitability of Ancient Mars

Understanding the habitability of ancient Mars is a key goal in the exploration of that planet. Evidence for conditions favorable to early life must be sought in ancient sedimentary rocks, such as those of Arabia Terra and Meridiani Planum. Arabia Terra, the northernmost extension of the ancient highlands, is dominated by cratered plains and minor ridged units. These plains extend south into the adjacent Meridiani Planum. The Opportunity rover landed in northern Meridiani, close to the border with Arabia. High resolution MOC images reveal extensive layered sequences across much of the Arabia and Meridiani region. These layers have been interpreted as eroded remnants of sedimentary rock deposits (Edgett, 2005). The layered sequences are concentrated in the SW quadrant of Arabia and in northern Meridiani. Preliminary mapping by Edgett (2005) distinguished four large scale layered sequences in the Arabia and Meridiani region. These have dimensions of hundreds to more than 1,000 km. MOLA altimetry shows that each of the sequences can attain a thickness of 200 to 400 m, with a total thickness greater than 1 km. The sequences are generally flat lying, with regional slopes of a few degrees. Much finer layering is evident within a number of craters. The plains and ridged units of the Arabia and Meridiani region were originally mapped as Noachian based on crater statistics, particularly the number of large craters (Scott and Carr, 1978). The layered sequences in the current study postdate many, but not all, of these large craters. The layered sequences have partially or totally filled a number of craters with diameters ranging from 20 to over 50 km. The topmost layered sequence, as well as the lower two sequences, have intermediate thermal inertia, as derived from THEMIS, indicative of moderate induration. The TES spectra from the lower sequences include features indicative of basalt. Some areas of the topmost sequence, which includes the Opportunity landing site, have TES spectra dominated by hematite. Just below this topmost sequence lies a sequence with higher thermal inertia, indicative of more indurated or coarser grained material. The TES spectra of this sequence lack distinctive mineral features, and the rocks may be obscured by a thin coating of dust. The layers have been extensively eroded. The uppermost sequences are characterized by deeply scalloped boundaries. Filled craters have been partially exhumed. Finely layered deposits within craters have been strongly dissected. Landforms uniquely attributable to wind erosion are rare, but erosive styles and geomorphology characteristic of water and possibly ice are present. The layered sequences in Arabia Terra and Meridiani Planum likely reflect an epoch when the planet was much more habitable than it is today. Several areas in these layered sequences are under intensive study as candidate landing sites for the 2009 Mars Science Laboratory

The Mars 2020 Perseverance Rover Mast Camera Zoom (Mastcam-Z) Multispectral, Stereoscopic Imaging Investigation

Mastcam-Z is a multispectral, stereoscopic imaging investigation on the Mars 2020 mission’s Perseverance rover. Mastcam-Z consists of a pair of focusable, 4:1 zoomable cameras that provide broadband red/green/blue and narrowband 400-1000 nm color imaging with fields of view from 25.6° × 19.2° (26 mm focal length at 283 μrad/pixel) to 6.2° × 4.6° (110 mm focal length at 67.4 μrad/pixel). The cameras can resolve (≥ 5 pixels) ∼0.7 mm features at 2 m and ∼3.3 cm features at 100 m distance. Mastcam-Z shares significant heritage with the Mastcam instruments on the Mars Science Laboratory Curiosity rover. Each Mastcam-Z camera consists of zoom, focus, and filter wheel mechanisms and a 1648 × 1214 pixel charge-coupled device detector and electronics. The two Mastcam-Z cameras are mounted with a 24.4 cm stereo baseline and 2.3° total toe-in on a camera plate ∼2 m above the surface on the rover’s Remote Sensing Mast, which provides azimuth and elevation actuation. A separate digital electronics assembly inside the rover provides power, data processing and storage, and the interface to the rover computer. Primary and secondary Mastcam-Z calibration targets mounted on the rover top deck enable tactical reflectance calibration. Mastcam-Z multispectral, stereo, and panoramic images will be used to provide detailed morphology, topography, and geologic context along the rover’s traverse; constrain mineralogic, photometric, and physical properties of surface materials; monitor and characterize atmospheric and astronomical phenomena; and document the rover’s sample extraction and caching locations. Mastcam-Z images will also provide key engineering information to support sample selection and other rover driving and tool/instrument operations decisions

31st Annual Meeting and Associated Programs of the Society for Immunotherapy of Cancer (SITC 2016) : part two

Background The immunological escape of tumors represents one of the main ob- stacles to the treatment of malignancies. The blockade of PD-1 or CTLA-4 receptors represented a milestone in the history of immunotherapy. However, immune checkpoint inhibitors seem to be effective in specific cohorts of patients. It has been proposed that their efficacy relies on the presence of an immunological response. Thus, we hypothesized that disruption of the PD-L1/PD-1 axis would synergize with our oncolytic vaccine platform PeptiCRAd. Methods We used murine B16OVA in vivo tumor models and flow cytometry analysis to investigate the immunological background. Results First, we found that high-burden B16OVA tumors were refractory to combination immunotherapy. However, with a more aggressive schedule, tumors with a lower burden were more susceptible to the combination of PeptiCRAd and PD-L1 blockade. The therapy signifi- cantly increased the median survival of mice (Fig. 7). Interestingly, the reduced growth of contralaterally injected B16F10 cells sug- gested the presence of a long lasting immunological memory also against non-targeted antigens. Concerning the functional state of tumor infiltrating lymphocytes (TILs), we found that all the immune therapies would enhance the percentage of activated (PD-1pos TIM- 3neg) T lymphocytes and reduce the amount of exhausted (PD-1pos TIM-3pos) cells compared to placebo. As expected, we found that PeptiCRAd monotherapy could increase the number of antigen spe- cific CD8+ T cells compared to other treatments. However, only the combination with PD-L1 blockade could significantly increase the ra- tio between activated and exhausted pentamer positive cells (p= 0.0058), suggesting that by disrupting the PD-1/PD-L1 axis we could decrease the amount of dysfunctional antigen specific T cells. We ob- served that the anatomical location deeply influenced the state of CD4+ and CD8+ T lymphocytes. In fact, TIM-3 expression was in- creased by 2 fold on TILs compared to splenic and lymphoid T cells. In the CD8+ compartment, the expression of PD-1 on the surface seemed to be restricted to the tumor micro-environment, while CD4 + T cells had a high expression of PD-1 also in lymphoid organs. Interestingly, we found that the levels of PD-1 were significantly higher on CD8+ T cells than on CD4+ T cells into the tumor micro- environment (p < 0.0001). Conclusions In conclusion, we demonstrated that the efficacy of immune check- point inhibitors might be strongly enhanced by their combination with cancer vaccines. PeptiCRAd was able to increase the number of antigen-specific T cells and PD-L1 blockade prevented their exhaus- tion, resulting in long-lasting immunological memory and increased median survival

Poor quality drugs: grand challenges in high throughput detection, countrywide sampling, and forensics in developing countries.

Throughout history, poor quality medicines have been a persistent problem, with periodical crises in the supply of antimicrobials, such as fake cinchona bark in the 1600s and fake quinine in the 1800s. Regrettably, this problem seems to have grown in the last decade, especially afflicting unsuspecting patients and those seeking medicines via on-line pharmacies. Here we discuss some of the challenges related to the fight against poor quality drugs, and counterfeits in particular, with an emphasis on the analytical tools available, their relative performance, and the necessary workflows needed for distinguishing between genuine, substandard, degraded and counterfeit medicines