Collective modes of a quasi two-dimensional Bose condensate in large gas parameter regime

We have theoretically studied the collective modes of a quasi two-dimensional (Q2D) Bose condensate in the large gas parameter regime by using a formalism which treats the interaction energy beyond the mean-field approximation. In the calculation we use the perturbative expansion for the interaction energy by incorporating the Lee, Huang and Yang (LHY) correction term. The results show that incorporation of this higher order term leads to detectable modifications in the mode frequencies.Comment: 10 pages, 2 figure

Human rotavirus-specific IgM memory B cells have differential cloning efficiencies and switch capacities and play a role in antiviral immunity in vivo

Q1Q110829-10840Protective immunity to rotavirus (RV) is primarily mediated by antibodies produced by RV-specific memory B cells (RV-mBc). Of note, most of these cells express IgM, but the function of this subset is poorly understood. Here, using limiting dilution assays of highly sort-purified human IgM mBc, we found that 62% and 21% of total (non-antigen-specific) IgM and RV-IgM mBc, respectively, switched in vitro to IgG production after polyclonal stimulation. Moreover, in these assays, the median cloning efficiencies of total IgM (17%) and RV-IgM (7%) mBc were lower than those of the corresponding switched (IgG IgA) total (34%) and RV-mBc (17%), leading to an underestimate of their actual frequency. In order to evaluate the in vivo role of IgM RV mBc in antiviral immunity, NOD/Shi-scid interleukin-2 receptor-deficient (IL-2Rnull) immunodeficient mice were adoptively transferred highly purified human IgM mBc and infected with virulent murine rotavirus. These mice developed high titers of serum human RV-IgM and IgG and had significantly lower levels than control mice of both antigenemia and viremia. Finally, we determined that human RV-IgM mBc are phenotypically diverse and significantly enriched in the IgMhi IgDlow subset. Thus, RV IgM mBc are heterogeneous, occur more frequently than estimated by traditional limiting dilution analysis, have the capacity to switch Ig class in vitro as well as in vivo, and can mediate systemic antiviral immunity

Partial regularisation of the incompressible μ(I)-rheology for granular flow

In recent years considerable progress has been made in the continuum modelling of granular flows, in particular the μ(I) -rheology, which links the local viscosity in a flow to the strain rate and pressure through the non-dimensional inertial number I . This formulation greatly benefits from its similarity to the incompressible Navier–Stokes equations as it allows many existing numerical methods to be used. Unfortunately, this system of equations is ill posed when the inertial number is too high or too low. The consequence of ill posedness is that the growth rate of small perturbations tends to infinity in the high wavenumber limit. Due to this, numerical solutions are grid dependent and cannot be taken as being physically realistic. In this paper changes to the functional form of the μ(I) curve are considered, in order to maximise the range of well-posed inertial numbers, while preserving the overall structure of the equations. It is found that when the inertial number is low there exist curves for which the equations are guaranteed to be well posed. However when the inertial number is very large the equations are found to be ill posed regardless of the functional dependence of μ on I . A new μ(I) curve, which is inspired by the analysis of the governing equations and by experimental data, is proposed here. In order to test this regularised rheology, transient granular flows on inclined planes are studied. It is found that simulations of flows, which show signs of ill posedness with unregularised models, are numerically stable and match key experimental observations when the regularised model is used. This paper details two-dimensional transient computations of decelerating flows where the inertial number tends to zero, high-speed flows that have large inertial numbers, and flows which develop into granular rollwaves. This is the first time that granular rollwaves have been simulated in two dimensions, which represents a major step towards the simulation of other complex granular flows

Secretory IgA directed to the inner core rotavirus VP6 protein contributes to protection via intracellular neutralization but not via immune exclusion

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