Diversity-Oriented Synthesis of Novel Benzimidazoles as Antimalarial agents via post Ugi MCR

An efficient strategy for the syntheses of highly diverse benzimidazoles in exceptional yields via post Ugi reactions has been described. In our methodology we have utilized isocyanide based Ugi-reaction followed by acid catalyzed condensation cyclization reaction under microwave irradiations. All benzimidazole derivatives showed moderate to good antimalarial activity when compared with chloroquine as reference compound. Among these compounds, three of them (8b), (8c), (8d) were found to be most potent towards antimalarial activity. The synthesized hybrids were examined for their purity with the help of thin layer chromatography. Different analytical techniques were employed for further characterization like Mass studies, NMRs (1H and 13C) and FT-IR

Improved Nutrient Management Practices for Enhancing Productivity and Profitability of Wheat under Mid-Indo-Gangetic Plains of India

Two-year field experiments were conducted to study the effect of different levels of inorganic fertilizers, farmyard manure (FYM), and bio-inoculants on wheat productivity and profitability. Results specified that judicious application of inorganic fertilizers, FYM, and bio-inoculants significantly increased the productivity and profitability of wheat. Data suggested that the aggregate levels of fertilizer up to 100% NPK ha−1 resulted in significant increases in all growth attributes, grain yield (+206%), straw yield (+177%), and harvest index (+7%) as compared to control. Meanwhile, plots with the application of 10 t ha−1 FYM significantly (p < 0.05) increased grain yield (+26%) and straw yield (+22%) as compared to the control. Similarly, significant enhancement in grain and straw yields was observed with the application of PGPR + VAM over no-inoculation. Results showed that the significantly higher grain and straw yield attained by application of 75% NPK fertilizer + 10 t ha−1 FYM was at par with the application of 100% NPK fertilizer alone. Further, net returns (profitability) and B:C ratio (2.37) were significantly higher with fertilization with 75% NPK + 10 t ha−1 FYM along with PGPR + VAM as compared to 100% NPK alone. Overall, it can be concluded that the combination of 75% NPK and 10 t ha−1 FYM along with PGPR + VAM represented the optimum for net return and B:C ratio and reduced (25%) dose of NPK as compared to the rest of the treatment combinations

Unlocking the Molecular Behavior of Natural Amine-Targeted Carbon Quantum Dots for the Synthesis of Diverse Pharmacophore Scaffolds via an Unusual Nanoaminocatalytic Route

Despite the fact that carbon quantum dots (CQDs) have significant catalytic potential, only emblematic applications that rely on simple acid–base or hydrogen-bonding activation pathways have been reported. In this study, natural amine-targeted CQDs (NAT-CQDs) have been successfully fabricated using a sustainable technique that harnesses a renewable green source. Based on a holistic sustainable assessment, the present approach for the synthesis of NAT-CQDs surpasses previously reported methods in terms of estimated circular and good-manufacturing-practice metrics. A set of spectroscopic and analytical techniques, including FTIR, XPS, conductometric assay, pH titration, 19FNMR, and 13CNMR confirms the presence of the assessable amino-rich groups (0.0083N) at the surface of NAT-CQDs. The occurrence of surface amine groups unlocked the molecular behavior of as-prepared NAT-CQDs and makes them an unprecedented nanoaminocatalytic platform for the synthesis of diverse pharmacophore scaffolds (>40 examples) via a one-pot Knoevenagel/(aza) Michael addition reaction in water at room temperature. The assessable amine group can covalently activate carbonyl groups through nucleophilic iminium activation modes in water and facilitate the ability to build valuable and therapeutic scaffolds on a gram scale. By transferring significant molecular primacy at the frontier of nanoscale materials, NAT-CQDs can thus bridge the gap between the nanoscale and molecular domains. This protocol can also be applied for the preparation of therapeutic anticoagulant drugs, warfarin, and coumachlor. All the reactions exhibited a high atom economy, low E-factor, low process mass intensity (PMI), high reaction mass efficiency (RME), high carbon efficiency (CE), and high catalyst reusability with overall high sustainable values. NAT-CQDs show high recyclability, and the spectral data of reused catalysts indicate that the NAT-CQDs maintained their surface chemistry and electronic properties, suggesting their stability under the tested conditions. This study presents a remarkable instance of NAT-CQDs showcasing covalent catalysis. Expanding on the aforementioned design concept, the utilization of NAT-CQDs’ “potential” as distinct colloidal organocatalysts in aqueous environments at the molecular level introduces valuable prospects for aminocatalytic pathways