Alien Registration- Parent, John H. (Monticello, Aroostook County)

https://digitalmaine.com/alien_docs/34057/thumbnail.jp

Alien Registration- Parent, Jennie H. (Milo, Piscataquis County)

https://digitalmaine.com/alien_docs/8343/thumbnail.jp

Targeting the BCL6 Transcription Factor in Ovarian Cancer

Ovarian cancer is one of the most common reproductive malignancies for women in the United States, as well as one of the deadliest. Many deaths attributed to ovarian cancer, as well as cancer generally, are due to metastasis of the original tumor to different tissues throughout the body. The BCL6 transcription factor has been identified to play a key role in the metastasis of these tumors, as well as the invasion of these cancer cells through mesothelial cell layers, which contributes to ovarian cancer’s unique metastatic behavior. In an attempt to target these metastases and prevent mesothelial penetration, drugs were identified as efficacious for BCL6 targeting through a mRNA transcript pattern screen from ovarian cancer cells treated with a BCL6 siRNA. Following identification of a small number of these compounds, 3-D cultured ovarian cancer cells were treated with these drugs to observe their effect on cell viability, spheroid formation, and mesothelial clearance through fluorescence microscopy. These data, coupled with intracellular protein expression and mRNA levels via qPCR and Western Blotting, provided both quantitative and qualitative methods of observing cancer cell response to novel and repurposed pharmaceutical treatments. The response of these cells, along with changes in the expression of BCL6 and its target genes, opens the door for future research into these compounds and treatment combinations that may be currently overlooked or unexplored

Alien Registration- Parent, Weldon H. (Monticello, Aroostook County)

https://digitalmaine.com/alien_docs/34058/thumbnail.jp

Microelectronics Process Engineering at San Jose State University: A Manufacturing-Oriented Interdisciplinary Degree Program

San Jose State University\u27s new interdisciplinary curriculum in Microelectronics Process Engineering is described. This baccalaureate program emphasizes hands-on thin-film fabrication experience, manufacturing methods such as statistical process control, and fundamentals of materials science and semiconductor device physics. Each course of the core laboratory sequence integrates fabrication knowledge with process engineering and manufacturing methods. The curriculum development process relies on clearly defined and detailed program and course learning objectives. We also briefly discuss our strategy of making process engineering experiences accessible for all engineering students through both Lab Module and Statistics Module series

The effect of internal gravity waves on cloud evolution in sub-stellar atmospheres

Context. Sub-stellar objects exhibit photometric variability which is believed to be caused by a number of processes such as magnetically-driven spots or inhomogeneous cloud coverage. Recent sub-stellar models have shown that turbulent flows and waves, including internal gravity waves, may play an important role in cloud evolution.Aims. The aim of this paper is to investigate the effect of internal gravity waves on dust cloud nucleation and dust growth, and whether observations of the resulting cloud structures could be used to recover atmospheric density information.Methods. For a simplified atmosphere in two dimensions, we numerically solve the governing fluid equations to simulate the effect on dust nucleation and mantle growth as a result of the passage of an internal gravity wave. Furthermore, we derive an expression that relates the properties of the wave-induced cloud structures to observable parameters in order to deduce the atmospheric density.Results. Numerical simulations show that the density, pressure and temperature variations caused by gravity waves lead to an increase of dust nucleation by up to a factor 20, and dust mantle growth rate by up to a factor 1:6, compared to their equilibrium values. Through an exploration of the wider sub-stellar parameter space, we show that in absolute terms, the increase in dust nucleation due to internal gravity waves is stronger in cooler (T dwarfs) and TiO2-rich sub-stellar atmospheres. The relative increase however is greater in warm(L dwarf) and TiO2-poor atmospheres due to conditions less suited for efficient nucleation at equilibrium. These variations lead to banded areas in which dust formation is much more pronounced, and lead to banded cloud structures similar to those observed on Earth. Conclusions. Using the proposed method, potential observations of banded clouds could be used to estimate the atmospheric density of sub-stellar objects

Balsam fir (Abies balsamea) establishment dynamics during a spruce budworn (Choristoneura fumiferana) outbreak: an evaluation of the impact of aging techniques

The effects of recurrent spruce budworm (Choristoneura fumiferana (Clem.)) outbreaks on balsam fir (Abies balsamea (L.) Mill.) mortality have been extensively studied in Canada. Most studies report substantial seedling recruitment of balsam fir during outbreaks when reproductive trees are dying. According to previous research, this contradiction could be due to inaccuracies in the conventional aging method. Counting the maximum number of growth rings found at the tree base would significantly underestimate tree age. Counting terminal bud scars found on the entire trunk, including buried stem, would give a more accurate tree age. In this study, we compare recruitment dynamics obtained for aging seedlings in two balsam fir populations (about 500 km apart) using (i) the conventional method and (ii) bud scar counts. For both populations, the conventional method shows substantial recruitment during adult mortality, while the second aging technique reveals reduced recruitment during the epidemic phase of the spruce budworm outbreak

Missing growth rings at the trunk base in suppressed balsam fir saplings

Numerous researchers have suggested a causal relationship between low leaf biomass in suppressed trees and the lack of radial growth at the base of the trunk. The objective of this study was to verify this relationship with suppressed balsam fir (Abies balsamea (L.) Mill.) saplings found growing in an old-growth fir stand. A total of 29 saplings varying in height from 67 to 183 cm were uprooted. All saplings had adventitious roots. All terminal bud scars (TBS) found between the apex of the terminal leader and the trunk base (first adventitious root) as well as those found below ground were localized, and rings were counted between TBS along the aboveground trunk. Various morphological traits and the ratio of photosynthetic tissue dry mass (P, needles) to non-photosynthetic tissue dry mass (nP, above-ground stem) were used as an indicator of tree vigour. Between 3 and 33 rings counted along the aboveground trunk were missing at the trunk base. The number of missing rings at the base of the trunk was correlated with total height (r = 0.41), height growth (r = -0.51), radial growth (r = -0.44), the P/nP ratio (r = -0.73), and the proportion of live crown (r = -0.62). Moreover, from 2 to 35 additional rings, missing at the trunk base, were found in the belowground section of trunk and these missing rings were associated with the adventitious roots phenomenon. In conclusion, suppressed firs had missing rings at the base of the trunk. When all of the missing rings were added to the number of rings counted at the base of the trunk, age estimates provided a different temporal pattern of recruitment compared with that obtained by solely counting rings at the base of the trunk. Stem analysis on the entire trunk is the best aging method for suppressed balsam fir saplings

Altitude Limits for Rotating Vector Model Fitting of Pulsar Polarization

Traditional pulsar polarization sweep analysis starts from the point dipole rotating vector model (RVM) approximation. If augmented by a measurement of the sweep phase shift, one obtains an estimate of the emission altitude (Blaskiewicz, Cordes, & Wasserman). However, a more realistic treatment of field line sweepback and finite altitude effects shows that this estimate breaks down at modest altitude ~ 0.1R_{LC}. Such radio emission altitudes turn out to be relevant to the young energetic and millisecond pulsars that dominate the \gamma-ray population. We quantify the breakdown height as a function of viewing geometry and provide simple fitting formulae that allow observers to correct RVM-based height estimates, preserving reasonable accuracy to R ~ 0.3R_{LC}. We discuss briefly other observables that can check and improve height estimates

População de referência no diagnóstico da composição nutricional (CND) em Mangueiras.

Resumo: A diagnose foliar teve início em meados do século 20; desde então, é objeto de muitas pesquisas e tem-se apresentado como a principal ferramenta para aumento da produtividade, pois permite um manejo eficiente da adubação, podendo dirimir limitações de um dado nutriente e adequar o balanço nutricional para uma determinada cultura. Objetivando contribuir com a diagnose nutricional da mangueira avaliou-se 221 talhões das variedades Palmer, Tommy Atkins e Espada, durante as safras agrícolas 2009/2010 e 2010/2011. Seguindo a proposição do Diagnóstico da Composição Nutricional (CND) e a exclusão dos dados aberrantes, foi possível definir que o ponto de inflexão que definiu as amostras com alto e baixo rendimento foi de 80,8 kg por planta. A distância de Mahalanobis foi eficiente em excluir os resultados aberrantes do banco de dados inicialmente proposto