The Youth Olympic Games and social networks (2010-2014): Evolution and challenges of new methods of communication for transmission of olympic values

El nacimiento de los Juegos Olímpicos de la Juventud coincide en el tiempo con la irrupción de las redes sociales proporcionando nuevos canales para divulgar las ideas pedagógicas de Pierre de Coubertin, el fundador de los Juegos Olímpicos modernos. Nankín 2014 supuso la consolidación del Movimiento Olímpico en las redes explorando nuevos mercados y estrategias que alcanzaron los 500 millones de usuarios en todo el mundo. La concepción de los medios sociales como herramientas enraizadas al ámbito local en un contexto global permitirá a las instituciones deportivas globales el diseño de estrategias de comunicación más directas, específicas e individualizadas de acuerdo a las particularidades de sus públicosThe birth of the Youth Olympic Games coincided with the emergence of social networks, providing new channels for disseminating the pedagogical ideas of Pierre de Coubertin – the founder of the modern Olympic Games. Nanjing 2014 served as the consolidation of the Olympic Movement in social networks, exploring new markets and strategies that reached 500 million users around the world. Understanding social media as a tool rooted at local level in a global context will allow global sporting institutions to design communication strategies that are more direct, specific and individualized, according to the particularities of their audience

Non Parametric ROC Summary Statistics

Receiver operating characteristic (ROC) curves are useful statistical tools for medical diagnostic testing. It has been proved its capability to assess diagnostic marker’s ability to distinguish between healthy and diseased subjects and to compare different diagnostic markers. In this paper we introduce non parametric ROC summary statistics to assess a ROC curve across the entire range of F P F s ∈ (0, 1) as well as over a restricted range of F P F s and compare them with some existing ones through a simulation study and through some real data examples. We also show their capability to compare two diagnostic markers

Conceptual Maps: A Resource for the Supported Learning in Technologies

Se describen las características fundamentales de los mapas conceptuales, se resalta su importancia como instrumento para la organización y sistematización de ideas y conocimientos y se ofrecen propuestas para su elaboración, especialmente vinculándolos al diseño y producción de materiales didácticos que sirvan de apoyo a diferentes modalidades de aprendizaje apoyadas en las tecnologías de la información y la comunicación.This paper describes the fundamental characteristics of conceptual maps, highlights its importance as an instrument for organization and sistematization of ideas and knowledge, and makes proposals for its construction, specially in connection with the design and production of educational stuff aimed at several information-technology supported learning modalities

Automated semantic annotation of rare disease cases: a case study

MOTIVATION: As the number of clinical reports in the peer-reviewed medical literature keeps growing, there is an increasing need for online search tools to find and analyze publications on patients with similar clinical characteristics. This problem is especially critical and challenging for rare diseases, where publications of large series are scarce. Through an applied example, we illustrate how to automatically identify new relevant cases and semantically annotate the relevant literature about patient case reports to capture the phenotype of a rare disease named cerebrotendinous xanthomatosis. RESULTS: Our results confirm that it is possible to automatically identify new relevant case reports with a high precision and to annotate them with a satisfactory quality (74% F-measure). Automated annotation with an emphasis to entirely describe all phenotypic abnormalities found in a disease may facilitate curation efforts by supplying phenotype retrieval and assessment of their frequency. Availability and Supplementary information: http://www.usc.es/keam/Phenotype Annotation/. Database URL: http://www.usc.es/keam/PhenotypeAnnotation

Cannabidiol treatment might promote resilience to cocaine and methamphetamine use disorders: A review of possible mechanisms

Currently, there are no approved pharmacotherapies for addiction to cocaine and other psychostimulant drugs. Several studies have proposed that cannabidiol (CBD) could be a promising treatment for substance use disorders. In the present work, the authors describe the scarce preclinical and human research about the actions of CBD on the effects of stimulant drugs, mainly cocaine and methamphetamine (METH). Additionally, the possible mechanisms underlying the therapeutic potential of CBD on stimulant use disorders are reviewed. CBD has reversed toxicity and seizures induced by cocaine, behavioural sensitization induced by amphetamines, motivation to self-administer cocaine and METH, context- and stress-induced reinstatement of cocaine and priming-induced reinstatement of METH seeking behaviours. CBD also potentiated the extinction of cocaine- and amphetamine-induced conditioned place preference (CPP), impaired the reconsolidation of cocaine CPP and prevented priming-induced reinstatement of METH CPP. Observational studies suggest that CBD may reduce problems related with crack-cocaine addiction, such as withdrawal symptoms, craving, impulsivity and paranoia (Fischer et al., 2015). The potential mechanisms involved in the protective effects of CBD on addiction to psychostimulant drugs include the prevention of drug-induced neuroadaptations (neurotransmitter and intracellular signalling pathways changes), the erasure of aberrant drug-memories, the reversion of cognitive deficits induced by psychostimulant drugs and the alleviation of mental disorders comorbid with psychostimulant abuse. Further, preclinical studies and future clinical trials are necessary to fully evaluate the potential of CBD as an intervention for cocaine and methamphetamine addictive disorders

Applying Recommendations to Align Competences, Methodology, and Assessment in Telematics, Computing, and Electronic Engineering Courses

The alignment between competences, teachinglearning methodologies, and assessment is a key element of European higher education. This paper presents the efforts carried out by six telematics, computer science and electronic engineering education teachers toward achieving this alignment in their subjects. In a joint work with pedagogues, a set of recommended actions are identified. A selection of these actions are applied and evaluated in the six subjects. The cross analysis of the results indicates that the actions allow students to better understand the methodologies and assessments planned for the subjects, facilitate (self-) regulation, and increase students’ involvement in the subjects

La conservación del patrimonio agroindustrial. Propuestas para la reutilización de los antiguos mataderos municipales y análisis de costes

La creciente demanda de alimentos en las áreas urbanas, junto con los avances en los transportes y la aparición de nuevas fuentes de energía propiciaron a finales del siglo XIX la construcción de diversas industrias agroalimentarias en el medio rural español. Un ejemplo de este patrimonio agroindustrial son los antiguos mataderos municipales, edificados en un gran número de localidades de la geografía española con el objetivo de evitar sacrificios clandestinos de ganado y de mejorar las condiciones higiénicas de la carne. Las cada vez mayores exigencias técnicas y sanitarias para este tipo de construcciones a partir de la década de los 70 y la progresiva sustitución de las instalaciones municipales por mataderos privados más modernos y de mayor capacidad provocaron el cierre y posterior abandono de muchos de estos edificios en las décadas siguientes. En el presen te trabajo se muestran cuatro propuestas concretas para la reutilización de este tipo de construcciones. A partir de la información recopilada de varios proyectos fin de carrera desarrollados por alumnos de la Escuela Técnica Superior de Ingenieros Agrónom os de Madrid, se describen las actuaciones y trabajos de rehabilitación necesarios en cada caso y se ofrece un estudio comparativo de costes entre proyectos de reutilización y obra nuev

Control de Sagina procumbens en viveros de arándano

Sagina procumbens es una mala hierba problemática en los viveros de arándano de la costa suroeste de España. Además de la falta de herbicidas autorizados, existe carencia de información sobre eficacia y selectividad de posibles candidatos para su inclusión en el registro. El objetivo de este trabajo ha sido conocer la eficacia y selectividad de una serie de herbicidas. Se han realizado ensayos de campo en tres ambientes y con tres momentos o formas de aplicación. El diseño experimental ha sido completamente al azar, con 3 ambientes x 3 momentos x 11 tratamientos x 6 repeticiones. Los resultados muestran unos buenos resultados de eficacia y selectividad de aclonifen, diflufenican y linurón. Los tratamientos con metribuzina, clopiralida y flazasulfurón causaron severos daños al cultivo. Oxifluorfen, pendimetalina y prosulfocarb tambien presentan riesgo de fitotoxicidad, y oxadiazon no mostró eficacia en el control de S. procumbens

Methodology for decentralized analysis: detection, quantification and in situ monitoring of pharmaceutical formulations removal by electro-Fenton

Water quality is essential to both human and ecosystem health, and a fast detection of emerging pollutants is claimed, along with effective wastewater treatment plants to eliminate these types of substances. The goal of this study was the development of a sensitive and selective methodology to customize a handle device that meets this demand. Clozapine and its pharmacological formulation, Leponex®, were used as a model. The results obtained from the studies by differential pulse voltammetry (DPV) demonstrated that this methodology allows a simpler and cheaper decentralized analysis without losing sensitivity, performing electrochemical measurements in situ, in real-time and directly without sample treatment, with a good precision (RSD 3.7 %) and excellent accuracy (recoveries between 97.6 and 99.9 %). Moreover, the methodology was successfully used for direct follow-up the medicine removal in real samples by electro-Fenton (EF) treatment. The results gathered showed a relative error of less than 2 % concerning the measurements made with the conventional potentiostat. Bearing this in mind, the effectiveness of these electrochemical techniques used in tandem with the comfort and high specificity offered by the portable device, a more exhaustive control of water quality can be achieved, thus improving the quality of life in the planet.Agencia Estatal de Investigación | Ref. PID2020-113667GB-I00Agencia Estatal de Investigación | Ref. PDC2021-121394-I00Agencia Estatal de Investigación | Ref. CTM2017-87326-RXunta de Galicia | Ref. ED431C 2017/47Xunta de Galicia | Ref. ED431D 2017/0

Inference on the symmetry point-based optimal cut-off point and associated sensitivity and specificity with application to SARS-CoV-2 antibody data

Acknowledgments. This work was supported by grants PID2019-104681RB-I00. Data courtesy of Dr Konstantina Kontopoulou.In the presence of a continuous response test/biomarker, it is often necessary to identify a cut-off point value to aid binary classification between diseased and non-diseased subjects. The symmetry-point approach which maximizes simultaneously both types of correct classification is one way to determine an optimal cut-off point. In this article, we study methods for constructing confidence intervals independently for the symmetry point and its corresponding sensitivity, as well as respective joint nonparametric confidence regions. We illustrate using data on the generation of antibodies elicited two weeks post-injection after the second dose of the Pfizer/BioNTech vaccine in adult healthcare workers