Ecto-and Endo-Parasites in Rodents and Shrews From Four Habitats in Selangor and Negeri Sembilan, Malaysia

The objectives of this study were to determine the rodent host species, to identify the parasites they harbor and to record those parasites that are of zoonotic importance. A total of 204 rodents were examined from four selected habitats in the states of Selangor and Negeri Sembilan, Malaysia. The rodents were captured alive from five urban sites in Kuala Lumpur, rice fields in Tanjung Karang, a coastal area in Port Dickson and a Primary Forest Reserve in Gombak, Selangor. Standard laboratory parasitological and statistical analyses were used. Fourteen different rodent species belonging to three different mammalian groups were identified. Rattus rattus diardii was the predominant rodent species (67%) trapped and examined. The study revealed 53.9 % of the rodents examined had at least one species of helminth. A total of 21 helminth species (7 cestodes, 12 nematodes, 1 trematode and 1 acanthocephala) were recovered. Gongylonema neoplasticum, Nippostrongylus braziliensis, Hepatojarkus malayae, Heterakis supomosa, Capillaria hepatica Raillietina sp. Hymenolepis nana, H.diminuta, Hymenolepis sp. and Taenia taeniaeformis were the predominant helminth species identified. The helminths of zoonotic importance: Capillaria hepatica, Rictularia tani, Angiostrongylus sp., Taenia taeniaeformis, Hymenolepis nana, H. diminuta, Raillietina sp, Moniliformis dubius, Armillifer moniliformis were also found. Trypanosoma sp. was the only blood parasite found in the 204 rodents examined. Fourty seven percent of the rodents were found to be infested with at least one of the 20 species of ecto-parasites recovered. The common ecto-parasites recovered were Laelaps nuttali, L. echidnanus, L. sculpturata, Polyplax spinulosa, Hoplopleura pacifica, Ixodes granulatus, Dermacentor sp. and Haemaphysalis sp. The ecto-parasites that are of human medical importance are Laelaps sp., Gahrlepia sp., Walchiella sp., Ornthonyssus bacoti, Haemaphysalis sp., Dermacentor sp., Ambloyomma sp. and Ixodes sp. and Xenopsylla cheopis. A total of 147 ecto-parasites (ticks, n=15, fleas, n= 31, lice, n=30 and mites, n=71) were recovered from the rodents. Rattus rattus diardii was found to harbour a wide range of ecto and endo-parasites some of which have been identified as zoonotic. There was no significant relationship between the sex of rodents and parasitic infestion. However, significant association was seen between ecto and endo-parasitic infection and habitats. Rodents from the urban habitats comparatively were found to harbour a wider range of parasites, some of which are of human medical importance

Distribution and morphological measurements of wild and urban rodents from four habitats in the states of Selangor and Negeri Sembilan, Malaysia

A total of 204 rodents comprising of 14 species were identified from four different habitats namely urban, forest, paddy field and coastal. The Gombak forest reserve habitat was found to be ideal for the survival of 11 different rodent species. Maxomys rajah, Leopoldamys sabanus and Sundamys muelleri were the predominant rodent species distributed in the Gombak forest. Rattus ratus diardii was found mainly in the urban, paddy field and coastal habitat (67.1%). Morphological measurements of the rodents trapped from the four habitats did not show any major changes

An overview of nematodes infecting urban and wild rats (Muridae) in Malaysia

Rodents particularly those belonging to the Muridae family in Malaysia have been well studied because of their medical and economic importance. Much of the work on rodents has been focusing on the identification of endo and ecto parasites. Parasites in rats (Murids) particularly helminthes belonging to the Nematoda family have been described by many workers for more than a century. This paper is an attempt to compile 50 papers on rodent nematodes that has been published in various scientific journals over the last 100 years in Malaysia. It is hoped that this literature overview on rodent nematodes will come useful as a reference material for the budding parasitologist and biology scientist

Global disparities in surgeons’ workloads, academic engagement and rest periods: the on-calL shIft fOr geNEral SurgeonS (LIONESS) study

: The workload of general surgeons is multifaceted, encompassing not only surgical procedures but also a myriad of other responsibilities. From April to May 2023, we conducted a CHERRIES-compliant internet-based survey analyzing clinical practice, academic engagement, and post-on-call rest. The questionnaire featured six sections with 35 questions. Statistical analysis used Chi-square tests, ANOVA, and logistic regression (SPSS® v. 28). The survey received a total of 1.046 responses (65.4%). Over 78.0% of responders came from Europe, 65.1% came from a general surgery unit; 92.8% of European and 87.5% of North American respondents were involved in research, compared to 71.7% in Africa. Europe led in publishing research studies (6.6 ± 8.6 yearly). Teaching involvement was high in North America (100%) and Africa (91.7%). Surgeons reported an average of 6.7 ± 4.9 on-call shifts per month, with European and North American surgeons experiencing 6.5 ± 4.9 and 7.8 ± 4.1 on-calls monthly, respectively. African surgeons had the highest on-call frequency (8.7 ± 6.1). Post-on-call, only 35.1% of respondents received a day off. Europeans were most likely (40%) to have a day off, while African surgeons were least likely (6.7%). On the adjusted multivariable analysis HDI (Human Development Index) (aOR 1.993) hospital capacity > 400 beds (aOR 2.423), working in a specialty surgery unit (aOR 2.087), and making the on-call in-house (aOR 5.446), significantly predicted the likelihood of having a day off after an on-call shift. Our study revealed critical insights into the disparities in workload, access to research, and professional opportunities for surgeons across different continents, underscored by the HDI

Gamma knife radiosurgery

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New biogeographical and morphological information on Physaloptera ngoci Le-Van-Hoa, 1961 (Nematoda: Physalopteridae) in South-east Asian rodents

During a study of the helminth fauna of 1,643 rodents trapped along the Mekong River (Thailand, LaoPeople"s Democratic Republic and Cambodia) in 2008-2011, the spirurid nematode Physaloptera ngoci Le-Van-Hoa,1961 was recovered with an overall prevalence of 2.8%. Based on the original description, it was identified in nine of 23 different Murinae host species and is here reported for the first time from these three countries. A scanning electron microscopy study provides additional morphological data

Endo-parasite fauna of rodents caught in five wet markets in Kuala Lumpur and its potential zoonotic implications.

Rodents were collected from five wet markets (Chow Kit, Dato Keramat, Setapak, Jinjang and Kepong) in Kuala Lumpur, Federal Territory between March to April 2006. Ninetyseven rats were trapped using wire traps measuring 29x22x50 cm baited with fruits, coconuts, dried fish or sweet potatoes. A total of 17 different species of parasites were identified from three species of rats out of which 11 (65%) were identified to be zoonotic. The helminths identified from the urban rats were nematodes- Capillaria hepatica, Gongylonema neoplasticum, Heterakis spumosa, Heterakis sp., Masterphorus muris, Nippostrongylus brasiliensis, Physolaptera sp., Pterogodermatis sp., Rictularia tani and Syphacia muris; cestodes- Hymenolepis nana, Hymenolepis diminuta, Hymenolepis sabnema, Hymenolepis sp., Raillietina sp. and Taenia taeniaeformis, and acanthocephalan- Moniliformis moniliformis. The following parasites are of potential medical importance: C. hepatica, G. neoplasticum, R. tani, S. muris, H. diminuta, H. nana, Raillietina sp. and T. taeniaeformis

Safety and Use of MLC601/MLC901 (NeuroAiDTM) in Primary Intracerebral Hemorrhage: A Cohort Study from the NeuroAiD Safe Treatment Registry

Background: MLC601/MLC901 (NeuroAiD™) is a combination of natural products shown to be safe and to aid neurological recovery after brain injuries, especially ischemic stroke. Few studies have investigated NeuroAiD in primary intracerebral hemorrhage (ICH). The NeuroAiD Safe Treatment (NeST) Registry explores NeuroAiD use in the real-world setting. This cohort study aimed to assess its use and safety in ICH. Methods: The online NeST Registry of subjects with ICH given NeuroAiD prospectively collected clinical data at baseline and monthly visits (V) 1 to 3. Outcome measures included compliance, side effects, Glasgow Coma Scale (GCS), National Institutes of Health Stroke Scale (NIHSS), modified Rankin Scale (mRS), and Short Orientation-Memory-Concentration Test (SOMCT). Results: Sixty-six subjects were included. NeuroAiD was well-tolerated with fair compliance over three months. Two non-serious side effects were reported. Mean scores significantly improved on all outcome scales. The proportion of subjects with favorable outcomes significantly improved from baseline to V3: NIHSS 0–4, from 12% to 59% (p < 0.0001); GCS 13–15, from 64% to 88% (p = 0.007); mRS 0–1, from 9% to 37% (p = 0.004); and SOMCT score 0–8, from 44% to 68% (p = 0.029). Conclusions: NeuroAiD in the real-world setting was safe and showed potential for a sustained positive effect on neurological recovery after ICH

Ectoparasite fauna of rodents and shrews from four habitats in Kuala Lumpur and the states of Selangor and Negeri Sembilan, Malaysia and its public health significance

A total of 204 rodents comprising 14 host species from four different habitats were examined. Nine rodent species were trapped from the forest and another five species were trapped from the coastal, rice field and urban habitats. Rattus rattus diardii (67%) was the predominant rodent species examined. Fifty six (47.3%) rodents and shrews were found to be infested with at least one of the 20 species of ectoparasite recovered. Mites belonging to the family Trombiculidae were the predominant ectoparasite species recovered. Ticks belonging to the family Ixodidae were recovered mainly from the forest dwelling rodents. Polyplax spinulosa and Hoplopleura pacifica were the common lice species found infesting the urban rodents. Xenopsylla cheopis was the only flea species recovered. The following ecto-parasites have been incriminated as important vectors or as mechanical carriers for the transmission of zoonotic diseases: Ixodes granulatus, Dermacentor sp. Haemaphysalis sp., Amblyomma sp. Ascoschoengastia indica, Leptotrombidium deliense, Ornithonyssus bacoti, Laelaps nuttalli, H. pacifica, P. spinulosa and Xenopsylla cheopis. Urban and forest rodents were significantly higher in ecto-parasitic infestation, compared to rats from the other two habitats. However, there was no significant statistical association between male and female rodents infested with ectoparasites