Tres apariencias distintas de la dominación

Esta comunicación pretende reflexionar sobre lo que se entiende por “dominación” y como ella se relaciona con la “soberanía”. Para ello se hará un pequeño recorrido histórico para analizar las distintas formas soberanas. Con este análisis se llegará a la época actual reinada por el libre mercado, con lo que se hará necesario reflexionar sobre él y vincularlo, si es preciso, con la dominación, a pesar de la contradicción incial.The aim of this paper is to think about what is understood by “domination” and how it is related with “sovereignty”. To take a brief looking to the history is need for this purpose, so that one could see different sovereign forms. With this brief history view one will arrive until today’s situation, where free market reigns. In this point rethinking free market will be need (what it exactly means, where the idea comes from, etc.) and it also will be necessary to think if there is a link between “free market” and “domination” despite of the initial contradiction

Ressenyes

Index de les obres ressenyades: Michael WALZER, Terrorismo y guerra justa + «me veo como un judío comunitario y como un americano liberal» (entrevista de Daniel Gamper Sachse

Tractament dels cadàvers a les clíniques veterinàries

Treball presentat a la Facultat de Veterinària de la Universitat Autònoma de Barcelona.Treball presentat a l'assignatura de Deontologia i Veterinària Legal (21223

Estudi de climatització i producció d’aigua calenta sanitària d’una piscina municipal coberta aplicant criteris d’estalvi energètic: bomba de calor i energia solar tèrmica

El projecte tracta sobre la climatització i producció d’aigua calenta sanitària d’una instal·lació esportiva, concretament una piscina coberta municipal de dos vasos. El treball es podria separar en cinc parts. La primera consisteix en definir la instal·lació en qüestió a partir de criteris d’arquitectura bioclimàtica. Es dona un èmfasi important als tancaments i els seus coeficients de transmissió. La segona en el càlcul de les necessitats energètiques per a l’hivern i per a l’estiu, també es diferencia el règim estacionari del transitori (emplenat de l’aigua dels vasos) en aquest càlcul. En la tercera es presentarà la solució per la qual es cobriran les necessitats mitjançant criteris d’estalvi energètic. S’utilitzarà energia solar tèrmica per a la producció aigua calenta sanitària (ACS) i escalfament de l’aigua dels vasos. Bomba de calor per a l’escalfament i deshumidificació de l’aire ambient interior, i escalfament de l’aigua dels vasos. I un generador convencional de calor, en aquest cas caldera de baixa temperatura, que cobreixi totes les necessitats de la piscina. En la quarta es dimensionarà la resta de la instal·lació: bescanviadors de plaques, bombes de circulació, circuits hidràulics, conductes d’aire, vasos d’expansió, etc. La cinquena i última part consisteix en un estudi energètic i econòmic sobre les alternatives d’estalvi energètic que s’han proposat. Amb un pressupost final de la instal·lació

Predicting functional impairment trajectories in amyotrophic lateral sclerosis: a probabilistic, multifactorial model of disease progression.

To employ Artificial Intelligence to model, predict and simulate the amyotrophic lateral sclerosis (ALS) progression over time in terms of variable interactions, functional impairments, and survival. We employed demographic and clinical variables, including functional scores and the utilisation of support interventions, of 3940 ALS patients from four Italian and two Israeli registers to develop a new approach based on Dynamic Bayesian Networks (DBNs) that models the ALS evolution over time, in two distinct scenarios of variable availability. The method allows to simulate patients' disease trajectories and predict the probability of functional impairment and survival at different time points. DBNs explicitly represent the relationships between the variables and the pathways along which they influence the disease progression. Several notable inter-dependencies were identified and validated by comparison with literature. Moreover, the implemented tool allows the assessment of the effect of different markers on the disease course, reproducing the probabilistically expected clinical progressions. The tool shows high concordance in terms of predicted and real prognosis, assessed as time to functional impairments and survival (integral of the AU-ROC in the first 36 months between 0.80-0.93 and 0.84-0.89 for the two scenarios, respectively). Provided only with measurements commonly collected during the first visit, our models can predict time to the loss of independence in walking, breathing, swallowing, communicating, and survival and it can be used to generate in silico patient cohorts with specific characteristics. Our tool provides a comprehensive framework to support physicians in treatment planning and clinical decision-making. [Abstract copyright: © 2022. The Author(s).

Common and rare variant association analyses in amyotrophic lateral sclerosis identify 15 risk loci with distinct genetic architectures and neuron-specific biology

Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease with a lifetime risk of one in 350 people and an unmet need for disease-modifying therapies. We conducted a cross-ancestry genome-wide association study (GWAS) including 29,612 patients with ALS and 122,656 controls, which identified 15 risk loci. When combined with 8,953 individuals with whole-genome sequencing (6,538 patients, 2,415 controls) and a large cortex-derived expression quantitative trait locus (eQTL) dataset (MetaBrain), analyses revealed locus-specific genetic architectures in which we prioritized genes either through rare variants, short tandem repeats or regulatory effects. ALS-associated risk loci were shared with multiple traits within the neurodegenerative spectrum but with distinct enrichment patterns across brain regions and cell types. Of the environmental and lifestyle risk factors obtained from the literature, Mendelian randomization analyses indicated a causal role for high cholesterol levels. The combination of all ALS-associated signals reveals a role for perturbations in vesicle-mediated transport and autophagy and provides evidence for cell-autonomous disease initiation in glutamatergic neurons

Common and rare variant association analyses in amyotrophic lateral sclerosis identify 15 risk loci with distinct genetic architectures and neuron-specific biology

A cross-ancestry genome-wide association meta-analysis of amyotrophic lateral sclerosis (ALS) including 29,612 patients with ALS and 122,656 controls identifies 15 risk loci with distinct genetic architectures and neuron-specific biology. Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease with a lifetime risk of one in 350 people and an unmet need for disease-modifying therapies. We conducted a cross-ancestry genome-wide association study (GWAS) including 29,612 patients with ALS and 122,656 controls, which identified 15 risk loci. When combined with 8,953 individuals with whole-genome sequencing (6,538 patients, 2,415 controls) and a large cortex-derived expression quantitative trait locus (eQTL) dataset (MetaBrain), analyses revealed locus-specific genetic architectures in which we prioritized genes either through rare variants, short tandem repeats or regulatory effects. ALS-associated risk loci were shared with multiple traits within the neurodegenerative spectrum but with distinct enrichment patterns across brain regions and cell types. Of the environmental and lifestyle risk factors obtained from the literature, Mendelian randomization analyses indicated a causal role for high cholesterol levels. The combination of all ALS-associated signals reveals a role for perturbations in vesicle-mediated transport and autophagy and provides evidence for cell-autonomous disease initiation in glutamatergic neurons

Common and rare variant association analyses in amyotrophic lateral sclerosis identify 15 risk loci with distinct genetic architectures and neuron-specific biology

Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease with a lifetime risk of one in 350 people and an unmet need for disease-modifying therapies. We conducted a cross-ancestry genome-wide association study (GWAS) including 29,612 patients with ALS and 122,656 controls, which identified 15 risk loci. When combined with 8,953 individuals with whole-genome sequencing (6,538 patients, 2,415 controls) and a large cortex-derived expression quantitative trait locus (eQTL) dataset (MetaBrain), analyses revealed locus-specific genetic architectures in which we prioritized genes either through rare variants, short tandem repeats or regulatory effects. ALS-associated risk loci were shared with multiple traits within the neurodegenerative spectrum but with distinct enrichment patterns across brain regions and cell types. Of the environmental and lifestyle risk factors obtained from the literature, Mendelian randomization analyses indicated a causal role for high cholesterol levels. The combination of all ALS-associated signals reveals a role for perturbations in vesicle-mediated transport and autophagy and provides evidence for cell-autonomous disease initiation in glutamatergic neurons.peer-reviewe