Cost variation study of antidepressant drugs

Background: Depression and anxiety disorders are the most common mental illnesses, each affecting in excess of 10-15% of the population at some time in their lives. Approximately 10-15% of those with severe depression attempt suicide at some point of time. Thus, it is important that symptoms of depression be recognized and treated appropriately.Methods: The prices of 15 antidepressant drugs, available in 43 different formulations were analyzed. Costs of different brands of a particular generic antidepressant drug being manufactured by different companies, in the same strength and dosage forms were used to calculate cost ratio and percentage cost variation.Results: This study shows that there is a wide variation in the prices of different brands of same antidepressant drug in Indian market. The highest cost ratio and percent cost variation was found for amitriptyline 50 mg, followed by bupropion 25 mg, amitriptyline 75 mg and dosulepin 50 mg. Highest number of brands of antidepressant drugs available in Indian market are for escitalopram 10 mg followed by escitalopram 5 mg and 20 mg.Conclusions: There is wide price variation of different brands of the same generic antidepressant drug in Indian market. Cost of a drug plays an important role in treatment of depression as it follows a long course and adherence to the treatment is related with drug cost. To decrease the wide cost variation among different brands of antidepressant drugs; it is high time to generate physician awareness about impact of cost effectiveness of drug regimen and for regulation of drug prices by the concerned agencies

Cost variation analysis of antidyslipidemic drugs

Background: Dyslipidemia is the most common cause of premature coronary atherosclerosis manifesting as ischemic heart disease. Hyperlipidemia has a major role in the causation of atherosclerosis and atherosclerosis-induced conditions, such as ischemic cerebrovascular disease, coronary heart disease (CHD) and peripheral vascular disease.Methods: The prices of 07 antidyslipidemic drugs, available in 19 different formulations marketed in 260 brands and 03 fixed dose combinations available in 11 different formulations marketed in 75 brands were analyzed. Costs of different brands of a particular generic antidyslipidemic drug being manufactured by different companies, in the same strength and dosage forms were used to calculate cost ratio and percentage cost variation.Results: In this study, it was found that there exists a wide cost variation among the different brands of same antidyslipidemic drugs in Indian market. Among individual antidyslipidemic drugs, highest cost ratio and percent cost variation was found for atorvastatin 20 mg, followed by atorvastatin 10 mg and atorvastatin 5 mg. Among fixed dose combinations for antidyslipidemic drugs, highest cost ratio and percent cost variation was found for atorvastatin 20 mg+fenofibrate 160 mg, followed by atorvastatin 10 mg+ezetimibe 10 mg and atorvastatin 20 mg+ezetimibe 10 mg. Highest number of brands of antidyslipidemic drugs available in Indian market are for atorvastatin 10 mg followed by atorvastatin 20 mg and rosuvastatin 10 mg. Highest number of brands of fixed dose combinations of antidyslipidemic drugs available in Indian market are for atorvastatin 10 mg+ezetimibe 10 mg and atorvastatin 10 mg+fenofibrate 160 mg.Conclusions: In Indian market, there is very wide price variation of different brands of the same generic antidyslipidemic drug. Treatment of dyslipidemia has long course of treatment. For long term adherence to the treatment, cost of a drug plays an important role for successful drug treatment. Various steps are needed to reduce this wide price variation of different brands of the same generic antidyslipidemic drug

Enterprise Mashups: Why did this Web 2.0 service fail?

Service Oriented Architecture (SOA) is increasingly popular among businesses today. As SOA enables Enterprise Mashups, rapid SOA adoption should lead to adoption of enterprise Mashups provided by IBM and other prominent providers. And yet the adoption is low enough for Yahoo and many others to shelve it. Why did it fail? This research tries to answer empirically by assessing user perception, as Web 2.0 adoption is a bottom-up phenomenon. Over six hundred responses over five years are examined using the importance-performance (IP) framework. The research concludes that users find Mashups important for business but the performance seriously lacking. Adoption may be expected only if the performance improves substantially. Users perceive Mashups as highly important for the purposes of Online Sales or Customer Service, Promotions and Marketing, and Purchasing and supplier communications. Users find Mashups important across all functional areas, especially Sales, Promotion and marketing, Production and Operations, and Procurement functions

A 3D computational model for investigating the Spatial heterogeneity of Polymicrobial biofilm using K-means Clustering

Biofilm is considered for the cause of many microbial infections which range from Cystic fibrosis to middle ear infections. The biofilm mode of growth is more significant than planktonic as the biofilm mode of growth is protected from acidic PH, host immune responses, metal toxicity and antibiotics. Antibiotic resistance is becoming a bigger threat to mankind than cancer. The inter and intra species communications play a vital role in the growth dynamics and survival of the biofilm. The emergence of Small colony variants by phenotypic switching from S.aureus in presence of 4- Hydroxy-2-heptylquinoline N-oxide (HQNO) which is produced by P.aeruginosa play a superior role because of its inherent resilience and host adaptability

Understanding of effects of potassium on cardiac tissue by medical students: a critical appraisal

Potassium (K+) is one of the most important ion present in the human body and involved in numerous physiological activities. It mainly affects heart and skeletal muscle but the effects are not confined to theses organs only. The article precisely focuses on the explaining the physiological as well as pathological aspects of potassium on cardiac tissue. This article tends to explain: The cause of difference in extra cellular and Intra cellular concentration of potassium when potassium channels are open in resting conditions, why are Purkinje fibers and ectopic tissue are more sensitive to effect of potassium, mechanisms responsible for increased action potential duration by hypokalemia and decreased action potential duration by hyperkalemia. Hypokalemia generates ectopic activities and hyperkalemia inhibits them, therapeutic effects of potassium administration without causing hyperkalemia. These issues will be discussed and try to be explained with the help of Ohm’s law , Nernst equation and Nernst potential to sort out the complicated actions of potassium on cardiac tissue in a simplified manner. The primary aim of article is to improve understanding of potassium physiology by medical graduates, secondarily, convey message regarding improvement in teaching methodology in Pharmacology for the benefit of new generations

Performance investigation of an innovative H-bridge derived multilevel inverter topology for marine applications

441-449An innovative single-phase and three-phase H-bridge derived multilevel inverter topology is being proposed in this manuscript. The proposed topology makes use of relatively fewer switching devices compared to conventional Cascaded H-Bridge (CHB) multilevel inverter. In other words, the proposed inverter topology is capable of producing more number of levels in the voltage waveform with same number of switching devices. It is also established in this paper, that this proposed topology is superior in terms of requirement of lesser number of gate driving circuits and reduction in the harmonic content in the output voltage waveform. The proposed inverter topologies are driven by SPWM modulation technique. These converter topologies are not only beneficial for the power conditioning systems in the power system network but also for the other novel applications like in marine ships. In this manuscript, the performance comparisons of the proposed inverter topologies with that of conventional topology based on simulation results with MATLAB/SIMULINK have been presented

Piloting Service Oriented Architecture—A Case Study in the Oil Industry

The Service Oriented Architecture (SOA) paradigm introduced a few years back has already become the driving force behind enterprise systems. It is also a force behind most cutting edge technologies today. Although much is written about SOA, empirical studies on its implementation are next to none. This exploratory case study examines a pilot implementation at an oil-drilling equipment manufacturing company to understand the process and issues involved in SOA adoption. The study depicts the implementation methodology and the roadmap adopted by this organization to help connect its disparate systems using enterprise SOA. This paper can help researcher better understand SOA implementation and help them further explore the managerial issues involved in implementing this new technology

A Rare Case of Segmental Clavicle Fracture in an Adolescent

Clavicular fractures commonly occur in adults and children. The usual mechanism of injury is a fall on the outstretched hand or direct trauma. The usual site of these fractures is the mid clavicle with lateral end and medial end clavicular fractures being less common, respectively. Segmental clavicular fractures have been reported in the literature; they usually occur at the medial and lateral ends and tend to occur in adults. Bipolar clavicular injuries involving medial and lateral ends have also been reported rarely but all in adults. We report a very rare case of segmental clavicular fracture involving the mid clavicle and lateral end in an adolescent caused by direct trauma. The management of segmental clavicle fractures has not been clearly outlined although operative intervention is indicated. We report the successful management of segmental fracture clavicle in an adolescent and discuss the relevant literature

Invesitigation of Malware and Forensic Tools on Internet

Malware is an application that is harmful to your forensic information. Basically, malware analyses is the process of analysing the behaviours of malicious code and then create signatures to detect and defend against it.Malware, such as Trojan horse, Worms and Spyware severely threatens the forensic security. This research observed that although malware and its variants may vary a lot from content signatures, they share some behaviour features at a higher level which are more precise in revealing the real intent of malware. This paper investigates the various techniques of malware behaviour extraction and analysis. In addition, we discuss the implications of malware analysis tools for malware detection based on various techniques