Targeting the Weak: A Content Analysis of Violence in Advergames

With a rising trend of targeting children using various means of advertisement, the popularity of advergames has significantly increased. Although previous research suggests that negative content in advergames result in less favorable attitudes toward the game (Waiguny, et al., 2013), the presence of violence in advergames targeted to children aged three to ten years is significantly high. Despite the growing concern regarding violence in advergames and other means of advertisement targeted to children, research has not yet investigated the actual amount of violence in advergames. To shed light on this important issue, the present research discusses results of a descriptive study along with a literature review of previously conducted studies. This research by no means is exhaustive, but does give a glimpse into the world of advergames and the possible negative effects associated with its content. The results of this study indicate, that roughly 38% of the advergames that were analyzed and discussed in this paper contain violence of some degree. These findings suggest parents should closely monitor their child\u27s online game type especially as it relates to advergames

Wave Propagation on Power Cables with Special Regard to Metallic Screen Design

The high frequency properties of coaxial power cables are modeled using time- and frequency-domain numerical simulations. This is required due to the complex helical structure of the outer metallic screen. The finite element (FEM) and finite difference time domain methods (FDTD) have been employed to study the effect of screen spiralization. It is established that this screen design causes a dependence of the cable high frequency characteristics on the surrounding medium. Analytical model based on modal analysis of wave propagation in coaxial cables confirms the numerical observations

Modeling the Wave Propagation Properties of Power Cables Using Numerical Simulations

The high frequency properties of coaxial power cables are modeled using time- and frequency-domain numerical simulations. This is required due to the complex helical structure of the outer metallic screen. It is established that this screen design causes a dependence of the cable characteristics on the surrounding mediu

Identification and Characterization of Histone H3 Lysine 23 Methylation in Germline Chromatin

Eukaryotic DNA and histone proteins are packaged into chromatin that can occur in two cytologically distinct states: heterochromatin, which is highly compacted and transcriptionally repressive; or euchromatin, which is relatively open and transcriptionally permissive. Increasing experimental evidence suggest that the structure and function of chromatin is governed, in part, by histone post-translational modifications (PTMs), but their characterization is generally protracted because of the biological complexities associated with higher eukaryotes. Moreover, recent studies have shown that euchromatin and heterochromatin represent the extremes of a continuum of physiological chromatin states, which may be encoded for by distinct combinations of histone PTMs. These states also have transcription-independent roles during interphase, mitosis, and meiosis that contribute to, among other activities, maintaining genomic stability. To screen for novel heterochromatin associated histone PTMs, we took advantage of the nuclear dimorphism afforded by the single-celled ciliate Tetrahymena thermophila. This model organism has two physically separable nuclei with its cytoplasm: a heterochromatic micronucleus (germline genome), and a euchromatic macronucleus (somatic genome). In this dissertation, I present our work identifying and characterizing histone H3 lysine 23 methylation (H3K23me) in the micronucleus. We report that H3K23 trimethylation (H3K23me3) is a micronucleus-specific heterochromatin modification that becomes particularly enriched during meiosis. Loss of H3K23me3, through deletion of its putative methyltransferase Ezl3p, causes mislocalization of meiosis-induced DNA double-strand breaks to heterochromatin, and decreases progeny viability. We extend the significance of H3K23me3 to higher eukaryotes by showing its meiotic upregulation is conserved in germlines of C. elegans and mice. In summary, our results suggest that the evolutionary conserved H3K23me3 plays an important role in protecting meiotic, germline heterochromatin from programmed DSBs

CLINICO-DIAGNOSТIC STUDIES OF SELLEK-FRADE'S ТЕSТ IN PAТIENTS WIТH EPIDEMIC HEPATIТIS

In recent years, due to its mass spread, epidemic hepatitis became а medical рroblem of world-wide importance. Оnе of the still unsatisfactorily solved prblems in connection with this infectious disease is the question related to its diagnosis. Extensive efforts are made to introduce appropriate and reliable clinico-laboratory test particularly having in mind the lack of trustworthy аnd practical applicble specific microbiological tests for etiological diagnosis.Informed from the literature about а new test - that of Sellek-Frade, we set ourselves the task to prove the diagnootic value of this test in оur patients, suffering from epidemic hepatitis.The test is introduced bу Sellek and Fгade in 1957 in Наbапа. The author recommend this test as а very easily performed flocculation test with а considerble diagпostic importance in hepatic disorders. The test is examined later in the clinic of А. Lemaire in Paris.Тhe test of Sellek and Frade is а colloid-stability test, in which cuprum acetate being used as а substance, which disturbs the colloid stability of blооd serum. Similar to most other colloid-stability tests this best becomes positive when the relation between albumins and globulins is disturbed

Solvation dynamics in a Brownian dipole lattice: a comparison between theory and computer simulation

Papazyan and Maroncelli [J. Chem. Phys. 95, 9219 (1991)] recently reported computer simulations of solvation dynamics of an ion in a Brownian dipole lattice solvent. In the present article we compare these results to predictions of a number of theories of solvation dynamics in the diffusive limit. The frequency-dependent dielectric response functions needed as input to many of the theories are derived from further simulations of the lattice solvent [H. X. Zhou and B. Bagchi, J. Chem. Phys. 97, 3610 (1992)]. When properly applied, all of the currently popular molecular theories yield reasonable predictions for the time scale of the solvation response. The dynamical MSA model [P. G. Wolynes, J. Chem. Phys. 86, 5133 (1987)] and the memory function theory of Fried and Mukamel [J. Chem. Phys. 93, 932 (1990)] both provide nearly quantitative agreement with all aspects of the solvation dynamics observed in these simulations

Structure of the germline genome of Tetrahymena thermophila and relationship to the massively rearranged somatic genome

The germline genome of the binucleated ciliate Tetrahymena thermophila undergoes programmed chromosome breakage and massive DNA elimination to generate the somatic genome. Here, we present a complete sequence assembly of the germline genome and analyze multiple features of its structure and its relationship to the somatic genome, shedding light on the mechanisms of genome rearrangement as well as the evolutionary history of this remarkable germline/soma differentiation. Our results strengthen the notion that a complex, dynamic, and ongoing interplay between mobile DNA elements and the host genome have shaped Tetrahymena chromosome structure, locally and globally. Non-standard outcomes of rearrangement events, including the generation of short-lived somatic chromosomes and excision of DNA interrupting protein-coding regions, may represent novel forms of developmental gene regulation. We also compare Tetrahymenas germline/soma differentiation to that of other characterized ciliates, illustrating the wide diversity of adaptations that have occurred within this phylum.</p