The neural correlates of phonological short-term memory: A repetitive transcranial magnetic stimulation study

Neuropsychological reports and activation studies by means of positron emission tomography anti functional magnetic resonance imaging have suggested that the neural correlates of phonological short-term memory are located in the left hemisphere, with Brodmann's area (BA) 40 being, responsible for short-term storage and BA 44 for articulatory rehearsal. However, a careful review of the literature on the role of left BA 40 shows that the data are equivocal. We tested We hypotheses by means of repetitive transcranial magnetic stimulation (rTMS). Participants performed four tasks: two phonological judgements, thought to require only articulatory rehearsal Without the contribution of short-term storage digit span, which involves both short-term storage and articudlatory rehearsal: and a pattern span, this last heing the control task. The sites of stimulation were left BA 40. left BA 44 anti the electrode location V-W plus a baseline without TMS. Reaction times increased and accuracy decreased in the case of the phonological judgement and digit span after stimulation of both left sites, suggesting that BA 40, in addition to BA 44. is involved in phonological judgements. Possible explanations are discussed, namely, the possibility that (i) the neural correlates of rehearsal are not limited to BA and (ii) phonological judgements invlove processes other than rehearsal. We also consider the effects of using different tasks and responses to resolve some of the descrepancies in the literature

A new test of action verb naming: normative data from 290 italian adults

Introduction Verbs and nouns can be selectively impaired, suggesting that they are processed, at least in part, by distinct neural structures. While several tests of object naming are available, tasks involving action verb naming with normative data are lacking. We report the construction and standardization of a new test for the assessment of picture naming of actions. Material and methods The test includes 50 stimuli, strictly controlled for several confounding variables. Normative data on 290 Italian subjects pooled across homogenous subgroups for age, sex, and education are reported. Results Multiple regression analyses revealed that age and education significantly correlated with the subject\u2019s score. In particular, increasing age negatively affected performance, while the performance increased with a higher education. Conclusions In the clinical practice, the availability of equivalent scores will help the comparison with performance in the picture naming of objects. This test allows investigating action naming deficits in aphasic patients, in Parkinson\u2019s disease patients and in further neurodegenerative disorders, in which a specific impairment of action verbs is expected, filling a gap in the clinical neuropsychological assessment

A computerized test of speed of language comprehension unconfounded by literacy

A computerised version of the Silly Sentences task developed for use with children (Baddeley et al, 1995) is found to be equivalent to the pencil-and-paper version from the SCOLP Test (Baddeley et al, 1992) with UK undergraduates, and is usable by a sample of young UK children. Because the sentences are presented aloud instead of being written, the computerised test is not affected by literacy skills. Translated into Kiswahili, the task was used in Tanzanian schools, despite the absence of an electricity supply and a very different cultural background. The decision latencies had a test-retest reliability of 0.69 over 5 months, and were independent of age and baseline decision speed. The task appears appropriate for longitudinal studies, including those in developing countries. Given its simplicity and the correlations with the original SCOLP version of the task, it may also be useful in studies on literate adults

Electronic structure of one-dimensional copper oxide chains in LiCu2O2 from angle-resolved photoemission and optical spectroscopy

Angle-resolved photoemission (ARPES) and optical measurements were performed on single crystal samples of LiCu2O2, an antiferromagnetic S=1/2 spin-chain compound. The ARPES spectra show several dispersive branches associated with hybrid copper-oxygen states. The occurrence of the valence band maximum halfway between the center and the edge of the Brillouin zone, and the complex spectral line shapes are not reproduced by the existing calculations of the electronic structure. We suggest that they can be interpreted within a one-dimensional scenario of strongly correlated antiferromagnetic insulators. The combination of ARPES and optics allows us to estimate the magnitude of the charge-transfer gap (Delta=1.95 eV). Moreover, the temperature-dependent optical conductivity bears signatures of the three different magnetic phases of this material

Foresight as a social construction of futures in territorial planning processes

Fil: Papagno, Silvina. Universidad Nacional de CuyoFil: Vitale, Javier. Universidad Nacional de CuyoFil: Barrientos, María Julia. Universidad Nacional de Cuy

Modulation of Visual Cortical Excitability by Working Memory: Effect of Luminance Contrast of Mental Imagery

Although much is known about the impact of stimulus properties such as luminance contrast, spatial frequency, and orientation on visually evoked neural activity, much less is known about how they modulate neural activity when they are properties of a mental image held in working memory (WM). Here we addressed this question by investigating how a parametric manipulation of an imagined stimulus attribute affects neuronal excitability in the early visual cortex. We manipulated luminance contrast, a stimulus property known to strongly affect the magnitude of neuronal responses in early visual areas. Luminance contrast modulated neuronal excitability, as assessed by the frequency of phosphenes induced by transcranial magnetic stimulation (TMS) with the exact nature of this modulation depending on TMS intensity. These results point to a strong overlap in the neuronal processes underlying visual perception and mental imagery: not only does WM maintenance selectively engage neurons which are tuned to the maintained attribute (as has previously been shown), but the extent to which those neurons are activated depends on the image contrast (as is the case with visually evoked responses). From a methodological viewpoint, these results suggest that assessment of visual cortical excitability using TMS is affected by the TMS intensity used to probe the neuronal population

Giant Spin-splitting in the Bi/Ag(111) Surface Alloy

Surface alloying is shown to produce electronic states with a very large spin-splitting. We discuss the long range ordered bismuth/silver(111) surface alloy where an energy bands separation of up to one eV is achieved. Such strong spin-splitting enables angular resolved photoemission spectroscopy to directly observe the region close to the band edge, where the density of states shows quasi-one dimensional behavior. The associated singularity in the local density of states has been measured by low temperature scanning tunneling spectroscopy. The implications of this new class of materials for potential spintronics applications as well as fundamental issues are discussed.Comment: 4 pages, 4 figure

Near-edge x-ray absorption fine structure investigation of graphene

We report the near-edge x-ray absorption fine structure (NEXAFS) spectrum of a single layer of graphite (graphene) obtained by micromechanical cleavage of Highly Ordered Pyrolytic Graphite (HOPG) on a SiO2 substrate. We utilized a PhotoEmission Electron Microscope (PEEM) to separately study single- double- and few-layers graphene (FLG) samples. In single-layer graphene we observe a splitting of the pi* resonance and a clear signature of the predicted interlayer state. The NEXAFS data illustrate the rapid evolution of the electronic structure with the increased number of layers.Comment: 5 pages, 4 figure