High-performance network traffic processing systems using commodity hardware

The final publication is available at Springer via http://dx.doi.org/10.1007/978-3-642-36784-7_1The Internet has opened new avenues for information ac- cessing and sharing in a variety of media formats. Such popularity has resulted in an increase of the amount of resources consumed in backbone links, whose capacities have witnessed numerous upgrades to cope with the ever-increasing demand for bandwidth. Consequently, network tra c processing at today's data transmission rates is a very demanding task, which has been traditionally accomplished by means of specialized hard- ware tailored to speci c tasks. However, such approaches lack either of exibility or extensibility|or both. As an alternative, the research com- munity has pointed to the utilization of commodity hardware, which may provide exible and extensible cost-aware solutions, ergo entailing large reductions of the operational and capital expenditure investments. In this chapter, we provide a survey-like introduction to high-performance network tra c processing using commodity hardware. We present the required background to understand the di erent solutions proposed in the literature to achieve high-speed lossless packet capture, which are reviewed and compared

iPTF16geu: A multiply imaged, gravitationally lensed type Ia supernova

We report the discovery of a multiply-imaged gravitationally lensed Type Ia supernova, iPTF16geu (SN 2016geu), at redshift $z=0.409$. This phenomenon could be identified because the light from the stellar explosion was magnified more than fifty times by the curvature of space around matter in an intervening galaxy. We used high spatial resolution observations to resolve four images of the lensed supernova, approximately 0.3" from the center of the foreground galaxy. The observations probe a physical scale of $\sim$1 kiloparsec, smaller than what is typical in other studies of extragalactic gravitational lensing. The large magnification and symmetric image configuration implies close alignment between the line-of-sight to the supernova and the lens. The relative magnifications of the four images provide evidence for sub-structures in the lensing galaxy.Comment: Matches published versio

Primary retroperitoneal mucinous cystadenoma with sarcoma-like mural nodule: A case report and review of the literature

Primary retroperitoneal cystadenomas are extremely rare. This is the first report in literature to describe a primary retroperitoneal cystadenoma with a sarcoma-like mural nodule. A 45-year-old woman complained of a left-sided abdominal mass. A computed tomography scan revealed a cystic mass with a mural nodule, which seemed to originate from the tail of the pancreas. At laparotomy the cyst was not adhered to the pancreas but localized retroperitoneally. Histologic examination showed a mucinous cystadenoma with only foci of borderline malignancy with a mural “sarcoma-like” nodule. In view of the surgical and histopathological findings, the mucinous cystadenoma was regarded as primary retroperitoneal. This case demonstrates that in the era of radiological preoperative refinement, pathological diagnosis remains of utmost importance, especially for rare cases

Association studies on 11 published colorectal cancer risk loci

Colorectal cancer (CRC) is the third most common cancer type in the Western world. Over one million patients are diagnosed worldwide yearly. A family history of CRC is a major risk factor for CRC. The total genetic contribution to disease development is estimated to be 35%. High-risk syndromes caused by known genes such as familial adenomatous polyposis (FAP) and Lynch Syndrome (LS) explain less than 5% of that number. Recently, several genome-wide association studies (GWAS) have independently found numerous loci at which common single-nucleotide polymorphisms (SNPs) modestly influence the risk of developing colorectal cancer. In total, germline mutations in known genes and moderate- and low risk variants are today suggested to explain 10-15% of the total genetic burden. Hence, predisposed genetic factor are still left to be found. The aim of paper I was to investigate if 11 published loci reported to be associated with an increased or decreased risk of colorectal cancer could be confirmed in a Swedish-based cohort. The cohort was composed of 1786 cases and 1749 controls that were genotyped and analyzed statistically. Genotype– phenotype analysis, for all 11 SNPs and sex, age of onset, family history of CRC and tumor location, was performed. Of 11 loci, 5 showed statistically significant odds ratios similar to previously published findings. Most of the remaining loci showed similar OR to previous publications. Four statistically significant genotype–phenotype associations were reported. The aim of paper II was to further study these 11 SNPs and their possible correlation with morphological features in tumors. We analyzed 15 histological features in 1572 CRC cases. Five SNPs showed statistically significant associations with morphological parameters. The parameters were poor differentiation, mucin production, decreased frequency of Crohn-like peritumoral reaction and desmoplastic response. The aim of paper III was to identify new CRC loci using a genome wide linkage analysis. We used 121 non-FAP/LS colorectal cancer families and genotyped 600 subjects using SNP array chips. No statistically significant result was found. However, suggestive linkage was found in the parametric analysis. This was observed in a recessive model for high-risk families, at locus 9q31.1 (HLOD=2.2) and for moderate-risk families, at locus Xp22.33 (LOD=2.2 and HLOD=2.5). Using families with early-onset, recessive analysis suggested one locus on 4p16.3 (LOD=2.2) and one on 17p13.2 (LOD/HLOD=2.0). Our linkage study adds support for the previously suggested region on chromosome 9 and suggests three additional loci to be involved in colorectal cancer risk. It is debated whether CRC is a single entity or two different entities, colon- and rectal cancer. Studies have recognized their molecular differences. The aim of paper IV was to identify novel colon- and rectal loci. We performed a genome wide linkage analysis using 32 colon- and 56 rectal cancer families. No LOD or HLOD score above three was observed. However, results close to three could be demonstrated. A maximum HLOD= 2.49 at locus 6p21.1-p12.1 and HLOD= 2.55 at locus 18p11.2 was observed for the colon- and rectal cancer families respectively. Exome sequencing was done, on colon and rectal patients, in these regions of interest. We report 25 variants mutated in family members on chromosome 6 and 27 variants on chromosome 18. Further studies are ongoing to elucidate the importance of these variants

Al-Gazali skeletal dysplasia constitutes the lethal end of ADAMTSL2-related disorders

First published: 10 March 2023. OnlinePublLethal short-limb skeletal dysplasia Al-Gazali type (OMIM %601356) is an ultra-rare disorder previously reported in only three unrelated individuals. The genetic etiology for Al-Gazali skeletal dysplasia has up until now been unknown. Through international collaborative efforts involving seven clinical centers worldwide, a cohort of nine patients with clinical and radiographic features consistent with short-limb skeletal dysplasia Al-Gazali type was collected. The affected individuals presented with moderate intrauterine growth restriction, relative macrocephaly, hypertrichosis, large anterior fontanelle, short neck, short and stiff limbs with small hands and feet, severe brachydactyly, and generalized bone sclerosis with mild platyspondyly. Biallelic disease-causing variants in ADAMTSL2 were detected using massively parallel sequencing (MPS) and Sanger sequencing techniques. Six individuals were compound heterozygous and one individual was homozygous for pathogenic variants in ADAMTSL2. In one of the families pathogenic variants were detected in parental samples only. Overall, this study sheds light on the genetic cause of Al-Gazali skeletal dysplasia and identifies it as a semi-lethal part of the spectrum of ADAMTSL2-related disorders. Furthermore, we highlight the importance of meticulous analysis of the pseudogene region of ADAMTSL2 where disease-causing variants might be located.Dominyka Batkovskyte, Fiona McKenzie, Fulya Taylan, Pelin Ozlem Simsek-Kiper, Sarah M Nikkel, Hirofumi Ohashi, Roger E Stevenson, Thuong Ha, Denise P Cavalcanti, Hiroyuki Miyahara, Steven A Skinner, Miguel A Aguirre, Zühal Akçören, Gulen Eda Utine, Tillie Chiu, Kenji Shimizu, Anna Hammarsjö, Koray Boduroglu, Hannah W Moore, Raymond J Louie, Peer Arts, Allie N Merrihew, Milena Babic, Matilda R Jackson, Nikos Papadogiannakis, Anna Lindstrand, Ann Nordgren, Christopher P Barnett, Hamish S Scott, Andrei S Chagin, Gen Nishimura, and Giedre Grigelionien

Type IIn supernova light-curve properties measured from an untargeted survey sample

The evolution of a Type IIn supernova (SN IIn) is governed by the interaction between the SN ejecta and a hydrogen-rich circumstellar medium. The SNe IIn thus allow us to probe the late-time mass-loss history of their progenitor stars. We present a sample of SNe IIn from the untargeted, magnitude-limited surveys of the Palomar Transient Factory (PTF) and its successor, the intermediate PTF (iPTF). To date, statistics on SN IIn optical light-curve properties have generally been based on small (≲10 SNe) samples from targeted SN surveys. The SNe IIn found and followed by the PTF/iPTF were used to select a sample of 42 events with useful constraints on the rise times as well as with available post-peak photometry. The sample SNe were discovered in 2009−2016 and have at least one low-resolution classification spectrum, as well as photometry from the P48 and P60 telescopes at Palomar Observatory. We study the light-curve properties of these SNe IIn using spline fits (for the peak and the declining portion) and template matching (for the rising portion). We study the peak-magnitude distribution, rise times, decline rates, colour evolution, host galaxies, and K-corrections of the SNe in our sample. We find that the typical rise times are divided into fast and slow risers at 20 ± 6 d and 50 ± 11 d, respectively. The decline rates are possibly divided into two clusters (with slopes 0.013 ± 0.006 mag d−1 and 0.040 ± 0.010 mag d−1), but this division has weak statistical significance. We find no significant correlation between the peak luminosity of SNe IIn and their rise times, but the more luminous SNe IIn are generally found to be more long-lasting. Slowly rising SNe IIn are generally found to decline slowly. The SNe in our sample were hosted by galaxies of absolute magnitude −22 ≲ M_g ≲ −13 mag. The K-corrections at light-curve peak of the SNe IIn in our sample are found to be within 0.2 mag for the observer’s frame r-band, for SNe at redshifts z <  0.25. By applying K-corrections and also including ostensibly “superluminous” SNe IIn, we find that the peak magnitudes are M^r_(peak) = −19.18 ± 1.32 mag. We conclude that the occurrence of conspicuous light-curve bumps in SNe IIn, such as in iPTF13z, are limited to 1.4^(+14.6)_(−1.0) % of the SNe IIn. We also investigate a possible sub-type of SNe IIn with a fast rise to a ≳50 d plateau followed by a slow, linear decline