A new lattice Boltzmann model for interface reactions between immiscible fluids

In this paper, we describe a lattice Boltzmann model to simulate chemical reactions taking place at the interface between two immiscible fluids. The phase-field approach is used to identify the interface and its orientation, the concentration of reactant at the interface is then calculated iteratively to impose the correct reactive flux condition. The main advantages of the model is that interfaces are considered part of the bulk dynamics with the corrective reactive flux introduced as a source/sink term in the collision step, and, as a consequence, the model’s implementation and performance is independent of the interface geometry and orientation. Results obtained with the proposed model are compared to analytical solution for three different benchmark tests (stationary flat boundary, moving flat boundary and dissolving droplet). We find an excellent agreement between analytical and numerical solutions in all cases. Finally, we present a simulation coupling the Shan Chen multiphase model and the interface reactive model to simulate the dissolution of a collection of immiscible droplets with different sizes rising by buoyancy in a stagnant fluid

Monte Carlo determination of the critical coupling in ϕ24\phi^4_2 theory

We use lattice formulation of $\phi^4$ theory in order to investigate non--perturbative features of its continuum limit in two dimensions. In particular, by means of Monte Carlo calculations, we obtain the critical coupling constant $g/\mu^2$ in the continuum, where $g$ is the {\em unrenormalised} coupling. Our final result is $g/\mu^2=11.15(6)(3)$.Comment: Version published on Phys. Rev. D. We added a reference and modified a couple of sentence

Perception And Construction of Individuals At The Intersect Of Race And Immigration Status

Although perceptions of intersectional group identities (e.g., race and gender) have gained focus in recent years, an oft-ignored group in this line of work are immigrants. Across three studies, attitudes and stereotypes of different groups as a function of race and immigrant status, and how experiences of racism affect people’s attitudes towards immigrants, were examined. Study 1 found attitudes and stereotypes clustered around target race, not immigration status (n = 498) though people’s attitudes were most favourable for Canadians with no attached race label. Study 2 found that experiences of racism affected attitudes towards immigrants expressed by a representative sample of Asian Americans (n = 3,511). These effects were not replicated in a study of Canadian undergraduates in which the salience of experiencing personal race-based discrimination was manipulated (n = 108). Together, these findings highlight the importance of examining immigrant attitudes from the majority and minority perspective

Emerging insights into atypical B cells in pediatric chronic infectious diseases and immune system disorders: T(o)-bet on control of B-cell immune activation

: repetitive or persistent cellular stimulation in vivo has been associated with the development of a heterogeneous B-cell population that exhibits a distinctive phenotype and, in addition to classical B-cell markers, often expresses the transcription factor T-bet and myeloid marker CD11c. research suggests that this atypical population consists of B cells with distinct B-cell receptor specificities capable of binding the antigens responsible for their development. the expansion of this population occurs in the presence of chronic inflammatory conditions and autoimmune diseases where different nomenclatures have been used to describe them. however, as a result of the diverse contexts in which they have been investigated, these cells have remained largely enigmatic, with much ambiguity remaining regarding their phenotype and function in humoral immune response as well as their role in autoimmunity. atypical B cells have garnered considerable interest because of their ability to produce specific antibodies and/or autoantibodies and because of their association with key disease manifestations. although they have been widely described in the context of adults, little information is present for children. Therefore, the aim of this narrative review is to describe the characteristics of this population, suggest their function in pediatric immune-related diseases and chronic infections, and explore their potential therapeutic avenues

Determinants of precocious B-cell aging in European adolescents living with perinatally acquired HIV-1 after over 10 years of suppressive therapy [preprint]

HIV infection results in a state of chronic immune activation leading to premature immune aging, B-cells dysfunction, that persists despite prolonged virological suppression. In this scenario, adolescence living with perinatally acquired HIV (PHIV), deserve a peculiar attention since potentially exposed for their entire life to chronic immune activation. Here we identified determinants of precocious aging B cells in 40 PHIV undergoing suppressive antiretroviral therapy (ART) for median 13.5 years. All individuals started ART by 2nd year of life and achieved virus suppression within the 1st year of ART, with majority of patient maintaining suppression until analysis and 5/40 experiencing viral Spike (transient elevation of HIV-1 VL, 50-999 copies/ml). We employed a multiomics approach including deep immunological B and T cell phenotype in PBMC, with aging B cells defined by the expression of T-bet and CD11c; plasma proteomics analysis by mass spectrometry and serum level of anti-measles antibodies as correlates of humoral response. We found that individuals with expansion of aging B cell, defined by the expression of T-bet+CD11c+, were those starting treatment later, presenting detectable levels of cell-associated HIV-1 RNA, history of Spikes, and a higher frequency of exhausted T-cells, including those expressing PD-1, LAG3, TIGIT. Accordingly, the proteomic analysis revealed that subjects with expansion of aging B cells and exhausted T cells had enrichment of proteins involved in immune inflammation and complement activation pathways, such as CLU and APCS which are also involved in tumor progression. Signs of precocious aging were associated with a reduced capacity to maintain virological memory against measles vaccination. To our knowledge, this is the first study focusing on precocious B-cell aging and dysfunctionality in PHIV with long-term virological suppression. Our experimental strategy enabled identification of clinical, viral, cellular and plasma soluble markers associated with B-cells aging. Our results pave the way to further define risk of disease progression or lymphoproliferative disorders in PHIV

Does the risk of arterial hypertension increase in the course of triptorelin treatment?

Gonadotropin-releasing hormone agonists (GnRH-a) are common treatment options for central precocious puberty (CPP) in childhood. GnRH-a treatment is useful and has a good safety profile, with minimal adverse effects and no severe long-term consequences. The common side effects in children are menopause-like symptoms and local adverse events at the injection site

A 4-study replication of the moderating effects of greed on socioeconomic status and unethical behaviour.

Four replications of Piff and colleagues\u27 study examined the moderating effects of greed attitudes on the relationship between socio-economic status (SES) and unethical behaviour (Study 7). In the original study, the researchers found that both greed and SES predicted increased propensity to engage in unethical behavior. Furthermore, this association was moderated such that the effects of SES on unethical behaviour were no longer present in the greed prime condition versus the neutral condition. In replication 1 of the original study main effects of greed attitudes and SES were found, but no interaction was found. Main effects for greed emerged in replications 3 and 4. However no main effects for SES or interactions emerged for replications 2-4. A meta-analysis was conducted with all replications and the original study, and found no moderating effect of greed on the relationship between SES and unethical behavior