Additional file 4: of Older patients are still under-represented in clinical trials of Alzheimer’s disease

Main characteristics of trials included in the age analyses (79). (DOCX 30 kb

Dementia as Risk Factor for Severe Coronavirus Disease 2019: A Case-Control Study

The aim of the present study was to investigate the outcome of patients with SARS-CoV-2 infection and dementia

A Polymer Bio–Photoelectrolytic Platform for Electrical Signal Measurement and for Light Modulation of Ion Fluxes and Proliferation in a Neuroblastoma Cell Line

Light control of living systems is an emerging field in bioelectronics, in regenerative medicine and cell‐based therapy. Herein, the design of a semitransparent bio–photoelectrolytic platform for control of a neuroblastoma cell line via light pulses is laid out. The platform is based on conjugated polymer films interfaced with a biological electrolyte solution confined in a compact chamber. Human SH‐SY5Y neuroblastoma cells are cultured for 3 days on the organic semiconductor and subjected to a pulsed light protocol. At the end of the culture time, proliferative activity of cells on the polymer film subjected to light pulses is reduced by 50% compared to the cultures kept in dark. An increase in intracellular Ca2+ level is observed, indicating a significant perturbation of the equilibrium potential of the cells. It is shown that the platform, in a sandwich‐type closed architecture with two transparent electrodes, can provide a tool for the initial recording of bioelectrical photovoltage signals (mV) that can complement analysis with more sophisticated electrophysiological tools. Obtained results can pave the way to new noninvasive photomanipulation techniques to stimulate/control living cells and their proliferation through both optical and electrical stimulation and probes, for application in the fields of biosensing and biomedicine

On the Stability of Selected Hydrogen-bonded Semiconductors in Organic Electronic Devices

The electronics era is flourishing and morphing itself into Internet of Everything, IoE. At the same time questions arise on the issue of electronic materials employed: especially their natural availability and low cost fabrication, their functional stability in devices, and finally their desired biodegradation at the end of the life cycle. Hydrogen bonded pigments and natural dyes like Indigo, Anthraquinone and Acridone have robustness in functionality and versatility in designing electronics and sensors components, and are bio-origin and biodegradable. With this Perspective Article, we intend to coalesce all the scattered reports on the above mentioned classes of Hydrogen bonded semiconductors, spanning across several disciplines and many active research groups. The article will comprise both published and un-published results, on stability during aging, upon electrical, chemical and thermal stress, and will finish with an outlook section related to biological degradation and biological stability of selected hydrogen bonded molecules employed as semiconductors in organic electronic devices. We demonstrate that when the purity, the long range order and the strength of chemical bond, are considered, then the Hydrogen-bonded organic semiconductors are the privileged class of materials having the potential to compete with inorganic semiconductors. As an experimental historical study of stability, we fabricated and characterized organic transistors from a material batch synthesized in 1932 and compared the results to fresh material batch

More Severe COVID-19 in Patients With Active Cancer: Results of a Multicenter Cohort Study

The aim of the study was to compare coronavirus disease 2019 (COVID-19) severity presentation between oncologic and non-oncologic patients and to evaluate the impact of cancer type and stage on COVID-19 course

Acinic cell carcinoma of the parotid gland: Timeo Danaos et dona ferentes? A multicenter retrospective analysis focusing on survival outcome

Objectives To analyze the demographic data, surgical and adjuvant treatment data and the survival outcomes in adult patients affected by acinic cell carcinoma of the parotid gland (AciCC). Methods A retrospective multicenter analysis of patients treated for AciCC of the parotid gland from 2000 to 2021 was per- formed. Exclusion criteria were pediatric (0–18 years) patients, the absence of follow-up and patients with secondary meta- static disease to the parotid gland. Multivariable logistic regression was used to determine factors associated with survival. Results The study included 81 adult patients with AciCC of the parotid gland. The median age was 46.3 years (SD 15.81, range 19–84 years), with a gender female prevalence (F = 48, M = 33). The mean follow-up was 77.7 months (min 4–max 361, SD 72.46). The 5 years overall survival (OS) was 97.5%. The 5 years disease-free survival (DFS) was 60%. No statisti- cal differences have been found in prognosis for age (< 65 or ≥ 65 years), sex, surgery type (superficial vs profound parotid surgery), radicality (R0 vs R1 + Rclose), neck dissection, early pathologic T and N stages and adjuvant therapy (p > 0.05). Conclusion This study did not find prognostic factor for poorest outcome. In contrast with the existing literature, our results showed how also high-grade tumours cannot be considered predictive of recurrence or aggressive behaviour