Intraoperative parathyroid hormone assay during surgery for secondary hyperparathyroidism: is it time to give up the chase at the hormone?

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Italiani brava gente. Un modo di dire legato al colonialismo italiano?

The article presents the initial results of research using statistical analysis to demonstrate the emergence of a new meaning of the idiomatic expression italiani brava gente linked to the history of the Italian colonialism. The idiomatic expression, who comes from the title of a 1964 by director De Santis (Italiani, brava gente), revives the myth of Italians who, unlike their Germans allies in the Second World War, stood out for their sense of good-naturedness and humanity, their inability to carry out atrocities in war, and their lack of racism and xenophobia. Starting from 2005, with the publication of a book by the historian Angelo Del Boca (Italiani, brava gente?), the idiomatic expression has definitively acquired a new meaning that links it in a critical sense to the history of Italian colonialism. To demonstrate the emergence of this new meaning, a collection of 292 articles from the historical archive of the newspaper «la Repubblica» where the idiomatic expression appears was analysed. The collection was divided into two sections: in the first, articles published from 1984 to 2005; in the second, articles produced from 2005 (after the edition of Del Boca’s book) to 31 October 2023. The results highlight that in the second group, there is a greater number of articles in which the idiomatic expression with the new meaning is used, and there is a greater frequency of words with lexical bases linked to the semantic field of Italian colonialism. This is preliminary research wich, despite already having a statistical value, will later be expanded with the consideration of other material, linked as well to the publishing sector

Fine-scale differences in diel activity among nocturnal freshwater planarias (Platyhelminthes: Tricladida)

<p>Abstract</p> <p>Background</p> <p>Although most freshwater planarias are well known photonegative organisms, their diel rhythms have never been quantified. Differences in daily activity rhythms may be particularly important for temperate-climate, freshwater planarias, which tend to overlap considerably in spatial distribution and trophic requirements.</p> <p>Methods</p> <p>Activity of stress-free, individually tested young adults of three common planarian species was recorded at 3-h intervals in a 10-d experiment under natural sunlight and photoperiod during autumnal equinox (D:L ~12:12). Individual activity status was averaged over the 10-d experiment, each tested individual thus serving as a true replicate. Twelve individuals per species were tested. Food was provided every 36 h, resulting in alternating day- and nighttime feeding events. Activity during the first post-feeding h was recorded and analyzed separately. Statistical procedures included ANOVAs, correlations, and second-order analyses of angles.</p> <p>Results</p> <p><it>Dugesia (= Girardia) tigrina </it>Girard 1850 exhibited clear nocturnal behavior, <it>Dugesia (= Schmidtea) polychroa </it>Schmidt 1861 was predominantly but not exclusively nocturnal, and <it>Polycelis tenuis </it>Ijima 1884 was relatively more active from midnight through noon. Species-specific activity peaks were statistically similar, with peaks at dawn for <it>P. tenuis </it>and just before midnight for the two dugesiids; however, <it>D. tigrina </it>was comparatively more active in the early night hours, while <it>D. polychroa </it>was more active than <it>D. tigrina </it>during daytime. <it>D. tigrina </it>also responded less readily to daytime food addition. <it>P. tenuis </it>remained poorly active and unresponsive throughout the experiment. Individual variability in diel behavior was highest for <it>D. polychroa </it>and lowest for <it>D. tigrina. P. tenuis</it>'s general low degree of activity and late activity peak in the experiment may be related to a strong reliance on external stimuli.</p> <p>Conclusions</p> <p>The tested species are mainly nocturnal, consistent with their photonegative characteristics. The fine-scale differences in diel behavior among these three triclad species may not be sufficient to allow coexistence in the wild, with the nonnative <it>D. tigrina </it>eventually displacing <it>D. polychroa </it>and <it>P. tenuis </it>in many European waters. The link between planarian diel rhythms and ecological characteristics are worth of further, detailed investigation.</p

Minimally Invasive Video-Assisted Parathyroidectomy: Lesson Learned from 137 cases

Abstract: Background: Since February 1997, a technique of minimally invasive video-assisted parathyroidectomy (MIVAP) was developed at our institution for the treatment of sporadic primary hyperparathyroidism (sPHPT). In this study we analyzed the entire series of patients who underwent MIVAP during the last 3 years. Study Design: One hundred thirty-seven patients with sPHPT were selected for MIVAP. Selection criteria were: diagnosis of single adenoma based on preoperative localization studies (ultrasonography, sestamibi scintigraphy, or both), and no previous neck surgery or concomitant large multinodular goiter. The procedure, already described, is performed by a gasless video-assisted technique through a single 1.5-cm central skin incision above the sternal notch. Quick, intraoperative parathyroid hormone assay was used in 134 cases (97.8%) to confirm the complete removal of all hyperfunctioning parathyroid tissue. Results: Mean operative time was 54.3 +/- 22.6 minutes. The conversion rate was 8.8%. One laryngeal nerve palsy was registered (0.7%), as was one case of persistent hyperparathyroidism. In six patients (4.4%) a transient symptomatic postoperative hypocalcemia was observed. Two thyroid lobectomies were associated using the same minimally invasive access. At a mean followup of 15.4 +/- 10.6 months, all but two patients were normocalcemic. The cosmetic result was considered excellent by most of the patients (92.8%). Conclusions: Although not all patients with sPHPT are eligible for MIVAP, this approach can now be proposed in a bigger proportion (67% of patients). As already demonstrated in a previous study, also in a large series of patients, after greater experience has been achieved, the results and the operative time are the same as in traditional surgery, with better cosmetic result and a less painful course. (J Am Coll Surg 2000; 191:613-618. (C) 2000 by the American College of Surgeons)

Length–weight relationships for some plecoptera and ephemeroptera from a carbonate stream in central Apennine (Italy)

The relationship between dry weight and body length for larvae of Plecoptera (Leuctra spp., Isoperla grammatica, Nemoura cinerea) and Ephemeroptera (Baetis spp., Habrophlebia fusca, Paraleptophlebia submarginata, Ecdyonurus helveticus, Rhithrogena semicolorata), collected from a carbonate stream in the Apennine (central Italy), is reported. The power equation f(x) = Ax B has been applied to fit the curves of dry weight vs. body size (length) in the ranges 0.03–13.00 mg and 2–14 mm, respectively; a total of 674 larvae were examined. The power model was in very good agreement with experimental data. Moreover, the error between measured and estimated weight was in the 4–20% range. The data on Isoperla grammatica, Leuctra spp., Rhithrogena semicolorata and Baetis spp. were compared to those in a previous study in a different geographical setting (south-western Germany's Black Forest) obtaining similar results but with lower errors. We used and compared two methods: the weighted least-square method (WLS) and an analysis of covariance (ANCOVA). The values of the A and B coefficients obtained with the two methods were very similar (<6% discrepancy for either A or B). We found the best fits for all the examined Plecoptera (species, genus, and order level), while the results for Ephemeroptera were varied, with loose fits at the order level and also for Leptophlebiidae collectively considered

A modification of the leaf-nets method for sampling benthic invertebrates in spring habitats

The full ecological potential of spring habitats remains relatively unexplored mostly because of the lack of standardized sampling procedures and difficulties to collect representative biological samples, especially in small-sized springs. Recent studies on sampling methodologies in spring habitats indicated that a modified Surber net with a reduced frame area, reliably describes the structure and composition of spring communities. This method, however, is very invasive and may severely impact the spring, especially when a large number of samples is required. The paper presents a new quantitative method (leaf-nets) for sampling crenic invertebrates which combines a rather high efficiency with negligible impacts on spring habitat structure and biota. The effectiveness of the new methodology was tested in a medium-size rheocrene spring in Central Apennine, where spring assemblages were sampled in parallel with a modified Surber net and with the new method. Taxa richness and density were higher in the Surber net, while no between-method differences were recorded for the number of insect taxa and Simpson diversity. Furthermore, the overall functional organization of Surber net and leaf-nets assemblages was very similar. The new method sampled only 25% of the individuals cumulatively collected, but 75% of the total richness, with a good representation of the structure and the functional organization of spring assemblages. In comparison with the Surber net, the negligible loss of information of the new method is highly compensated by its minor invasivity, lower impacts on spring microhabitats and invertebrate populations and by its higher versatility. Leaf-nets could also be used to assess leaf-detritus breakdown in springs, thus allowing a better ecological characterization of these ecosystems. </p

'Incidental' and 'non-incidental' thyroid papillary microcarcinomas are two different entities

Papillary thyroid microcarcinomas (microPTC) may be 'incidental' (Inc-microPTC), occasionally found at histology after surgery for benign disease or 'non-incidental' (Non-Inc-microPTC), diagnosed on clinical grounds. It is unclear whether these different microPTC reflect the same disease. The aim of the study was to compare Inc-microPTC and Non-Inc-microPTC for clinical and histological features as well as for serum TSH, a known factor involved in PTC development

Emerging Therapeutic Approaches for the Most Aggressive Epithelial Thyroid Cancers

The majority of epithelial thyroid carcinomas (TC) have a differentiated (DTC) histotype and include the papillary (PTC) and the follicular (FTC) TC which, ensuing dedifferentiation, generate the aggressive poorly differentiated (PDTC) and anaplastic (ATC) TC. Although derived from the same cell type, each TC shows specific histological features, biological behavior, and degree of differentiation because of different genetic alterations. Total thyroidectomy, followed by adjuvant therapy with 131I, is the treatment of choice for most patients affected by DTC. The prognosis of DTC patients is favorable, with 10‐year survival rate of nearly 90%. However, one third of them face the morbidity of disease recurrence and TC‐related deaths. The worst outcomes are encountered in patients with PDTC and ATC. The latter, in particular, has a mean survival time of few months from the diagnosis, which is not influenced by current anticancer treatments. Following the progress made in the comprehension of the underlying molecular mechanisms deregulated in TC progression, novel therapeutic approaches have come to light. Here, we will attempt to review new targeted therapies, which are currently being exploited in preclinical and clinical studies, with tyrosine kinase inhibitors as well as with emerging inhibitors of mitotic kinases, in PDTC and ATC

Molecular genetic features and risk assessment in a series of 30 patients who underwent an operation for gastrointestinal stromal tumours

Background: The objective of the study was to investigate the relationship between molecular genetic features and the standard criteria of risk assessment in patients affected by gastrointestinal stromal tumours (GISTs). Methods: A review was conducted of a series of 30 patients, with a mean age of 67 years, who underwent surgery for primary GISTs. R0 resection was accomplished in 27 patients. CD117, CD34 desmin, vimentin, S-100 and smooth muscle actin were immunohistochemically tested to achieve a diagnosis of GIST. The loss of wild-type KIT or platelet-derived growth factor receptor alpha (PDGFRα) genes was investigated by sequencing the tumour DNA. Results: Tumour genes mutations were reported in 23 patients (77%), and wild-type in seven. Mutations on the KIT gene occurred in 18 patients, and mutations on the PDGFRα gene in five. The average sizes of the GIST were 8.7 cm, 5.4 cm and 5.9 cm for KIT gene-mutated, PDGFRα gene-mutated and wild-type tumours, respectively. KIT gene mutations were detected in 50% of gastric and in 70% of extragastric GISTs. Moreover, 70% of tumours with a mitotic rate ≥ 5 x 50 highpower fields (HPFs) underwent KIT gene mutations. Conversely, PDGFRα mutations were observed only in gastric GISTs with a mitotic rate ≤ 5 x 50 HPFs. By stratifying GISTs according to classes of risk, KIT mutation was shown in most of the high-risk tumours. PDGFRα mutations occurred exclusively in lower classes of risk. Conclusion: Molecular analysis data might have a role as a prognostic variable in models of risk assessment for patients with GISTs

Diritto e Mercato

The purpose of this contribution is to examine the relationship between law and market from a cross-cutting legal perspective. The Authors, after summarising the evolution of this relationship over time, in particular, try to highlight how the logic of the market have determined a process of ‘functionalization’ of the law, according to which the law seems to comply with the with the way the market works and not vice-versa. In this process, the contribution of soft law, as well as new criteria and types of standardization play a key role, which, due to their greater flexibility, seem more suitable to meet the needs of the market, replacing traditional regulatory tools of hard law