L’historicisation juridique de la Couronne entre 1584 et 1593

In 1584, the Crown of France was contested, as was the law of succession. In the midst of the dynastic crisis, a process of juridical historicisation of the Crown was unleashed, during which all historical accounts aimed to support a candidate for the throne, while political writings favouring a pretender were always based on a certain history of the Crown and of France. Historical objectivity and its methods thus emerge as major strategic devices in political conflict.En 1584, la Couronne de France est contestée, ainsi que la loi de succession. Au sein de la crise dynastique, un procès d’historisation juridique de la Couronne se déclenche, durant lequel tout récit historique vise à soutenir un candidat au trône, tandis que les écrits politiques favorisant un prétendant s’appuient toujours sur une certaine histoire de la Couronne et de la France. L’objectivité historique et ses procédés apparaissent ainsi comme des dispositifs stratégiques majeurs du conflit politique

Manipulating liquids with robots: A sloshing-free solution

This paper addresses the problem of suppressing sloshing dynamics in liquid handling robotic systems by an appropriate design of position/orientation trajectories. Specifically, a dynamic system, i.e. the exponential filter, is used to filter the desired trajectory for the liquid-filled vessel moved by the robot and counteract the sloshing effect. To this aim, the vessel has been modelled as a spherical pendulum of proper mass/length subject to the accelerations imposed by the robot and the problem has been approached in terms of vibration suppression to cancel the residual oscillations of the pendulum, i.e. the pendulum swing at the end of the reference rest-to-rest motion. In addition, in order to reduce the relative motion between liquid and vessel, an orientation compensation mechanism has been devised aiming to maintain the vessel aligned with the pendulum during the motion. The effectiveness of the proposed approach, both in simple point-to-point motions and complex multi-point trajectories, has been proved by means of an exhaustive set of experimental tests on an industrial manipulator that moves a cylindrical vessel filled with water. This innovative solution effectively uses all the degrees of freedom of the robotic manipulator to successfully suppress sloshing, thus significantly improving the performances of the robotic system. Furthermore, the proposed solution, showing a high degree of robustness as well as intrinsic design simplicity, is very promising for designing novel industrial robotics applications with a short time-to-market across key manufacturing sectors (e.g., food and beverage, among others)

Medium term effects of a ketogenic diet and a Mediterranean diet on resting energy expenditure and respiratory ratio

none6noneAntonio Paoli;Keith Grimaldi;Antonino Bianco;Alessandra Lodi;Lorenzo Cenci;Andrea ParmagnaniPaoli, Antonio; Keith, Grimaldi; Antonino, Bianco; Lodi, Alessandra; Lorenzo, Cenci; Parmagnani, Andre

Versatile vessel-on-a-chip platform for studying key features of blood vascular tumors

Tumor vessel-on-a-chip systems have attracted the interest of the cancer research community due to their ability to accurately recapitulate the multiple dynamic events of the metastatic cascade. Vessel-on-a-chip microfluidic platforms have been less utilized for investigating the distinctive features and functional heterogeneities of tumor-derived vascular networks. In particular, vascular tumors are characterized by the massive formation of thrombi and severe bleeding, a rare and life-threatening situation for which there are yet no clear therapeutic guidelines. This is mainly due to the lack of technological platforms capable of reproducing these characteristic traits of the pathology in a simple and well-controlled manner. Herein, we report the fabrication of a versatile tumor vessel-on-a-chip platform to reproduce, investigate, and characterize the massive formation of thrombi and hemorrhage on-chip in a fast and easy manner. Despite its simplicity, this method offers multiple advantages to recapitulate the pathophysiological events of vascular tumors, and therefore, may find useful applications in the field of vascular-related diseases, while at the same time being an alternative to more complex approaches.D.C. received funding from the Secretary for Universities and Research of the Ministry of Economy and Knowledge of the Government of Catalonia and the COFUND program of the Marie Curie Actions of the 7th R&D Framework Program of the European Union (BP-DGR 2013). This work was partially funded by Spanish Science Ministry PCIN-2016-025 “Nanovacunas diseñadas para inmunoterapia antitumoral” (NANOVAX) EuroNanomed II platform, and PI20/0056 “Precision medicine in portal vein thrombosis: identification of new therapeutic targets and development of a unique theranostic approach”. Additionally, from the European Commission H2020-MSCA-ITN-2019, Grant Agreement N860436, “EVIDENCE”. The authors also thank the Spanish Ministry of Economy, Industry and Competitiveness through the project SAF2016-75241-R, the Obra Social La Caixa Foundation, and the European Research Council (ERC- StG-757397). The Nanobioengineering Group has support from the Commission for Universities and Research of the Department of Innovation, Universities, and Enterprise of the Generalitat de Catalunya (2017 SGR 1079)

Physiochemical responses of Ailanthus altissima under the challenge of Verticillium dahliae: elucidating the decline of one of the world’s worst invasive alien plant species

Natural infections of Verticillium spp. (Fungi, Ascomycota) on Ailanthus altissima have suggested to consider the biological control as a promising strategy to counteract this invasive plant, which is otherwise difficult to control by traditional mechanical and chemical treatments. Verticillium wilt is able to lead plants to death, throughout a pathogenic mechanism including vessel occlusions and production of degrading enzymes and phytotoxins. In this study, a 10 weeks open air pot experiment was set to investigate the ecophysiological and biochemical responses of Ailanthus trees artificially inoculated in the trunk with the V. dahliae strain VdGL16, previously isolated in Central Italy from the same host. Inoculated plants showed visible injuries starting from 2 weeks post inoculation (wpi), that progressively developed until a final severe defoliation. The fungal infection rapidly compromised the plant water status, and photosynthesis was impaired due to both stomatal and mesophyll limitations from 4 wpi, with subsequent detrimental effects also on PSII activity. Moreover, the disease altered the translocations of nutrients, as confirmed by cation and carbohydrate contents, probably due to a consumption of simple sugars and starch reserves without replacement of new photosynthesized. An accumulation of osmolytes (abscisic acid and proline) and phenylalanine (a precursor of phenylpropanoids) was also reported at 8 wpi, this being a response mechanism that needs to be further elucidated. However, the activation delay of such defence strategy inevitably did not avoid the premature defoliation of plants and the decline of physiochemical parameters, confirming the key role of Verticillium in Ailanthus decay

How much do young Italians know about COVID-19 and what are their attitudes toward SARS-CoV-2? Results of a cross-sectional study

Objectives: At the end of 2019, an outbreak of novel coronavirus pneumonia, called severe acute respiratory syndrome coronavirus 1 (SARS-CoV-2), was first identified in Wuhan, Hubei Province, China. It subsequently spread throughout China and elsewhere, becoming a global health emergency. In February 2020, the World Health Organization (WHO) designated the disease coronavirus disease 2019 (COVID-19). The objective of this study was to investigate the degree of knowledge of young Italians about COVID-19 and their current attitudes toward the SARS-CoV-2 and to determine if there were prejudices emerging toward Chinese. Methods: An online survey was conducted on February 3, 4, 5, 2020, with the collaboration of Italian website “Skuola.net”. Young people had the opportunity to participate by answering an ad hoc questionnaire created to investigate knowledge and attitudes about the new coronavirus, using a link published on the homepage. Results: A total of 5234 responses were received, of which 3262 were females and 1972 were males. Most of the participants showed generally moderate knowledge about COVID-19. Male students, middle school students, and those who do not attend school, should increase awareness of the disease; less than half of responders say that their attitudes toward the Chinese population has worsened in the last period

Breast lesion detection through MammoWave device: microwave images’ parameters

MammoWave is a microwave imaging device for breast lesions detection, which operates using two (azimuthally rotating) antennas without any matching liquid. Images, subsequently obtained by resorting to Huygens Principle, are intensity maps, representing the homogeneity of tissues’ dielectric properties. In the paper: “Breast lesion detection through MammoWave device: empirical detection capability assessment of microwave images’ parameters”, we propose to generate, for each breast, a set of conductivity weighted microwave images by using different values of conductivity in the Huygens Principle imaging algorithm. Next, microwave images’ parameters, i.e. features, are introduced to quantify the non-homogenous behaviour of the image. This data set contains such features. We empirically verify on 103 breasts that a selection of these features may allow distinction between breasts with no radiological finding (NF ) and breasts with radiological findings (WF), i.e. with lesions which may be benign or malign. Statistical significance was set at p <0.05. We obtained single features Area Under the receiver operating characteristic Curves (AUCs) spanning from 0.65 to 0.69. In addition, an empirical rule-of-thumb allowing breast assessment is introduced using a binary score S operating on an appropriate combination of features. Performances of such rule-of-thumb are evaluated empirically, obtaining a sensitivity of 74%, which increases to 84% when considering dense breasts only