Association of kidney disease measures with risk of renal function worsening in patients with type 1 diabetes

Background: Albuminuria has been classically considered a marker of kidney damage progression in diabetic patients and it is routinely assessed to monitor kidney function. However, the role of a mild GFR reduction on the development of stage 653 CKD has been less explored in type 1 diabetes mellitus (T1DM) patients. Aim of the present study was to evaluate the prognostic role of kidney disease measures, namely albuminuria and reduced GFR, on the development of stage 653 CKD in a large cohort of patients affected by T1DM. Methods: A total of 4284 patients affected by T1DM followed-up at 76 diabetes centers participating to the Italian Association of Clinical Diabetologists (Associazione Medici Diabetologi, AMD) initiative constitutes the study population. Urinary albumin excretion (ACR) and estimated GFR (eGFR) were retrieved and analyzed. The incidence of stage 653 CKD (eGFR < 60 mL/min/1.73 m2) or eGFR reduction > 30% from baseline was evaluated. Results: The mean estimated GFR was 98 \ub1 17 mL/min/1.73m2 and the proportion of patients with albuminuria was 15.3% (n = 654) at baseline. About 8% (n = 337) of patients developed one of the two renal endpoints during the 4-year follow-up period. Age, albuminuria (micro or macro) and baseline eGFR < 90 ml/min/m2 were independent risk factors for stage 653 CKD and renal function worsening. When compared to patients with eGFR > 90 ml/min/1.73m2 and normoalbuminuria, those with albuminuria at baseline had a 1.69 greater risk of reaching stage 3 CKD, while patients with mild eGFR reduction (i.e. eGFR between 90 and 60 mL/min/1.73 m2) show a 3.81 greater risk that rose to 8.24 for those patients with albuminuria and mild eGFR reduction at baseline. Conclusions: Albuminuria and eGFR reduction represent independent risk factors for incident stage 653 CKD in T1DM patients. The simultaneous occurrence of reduced eGFR and albuminuria have a synergistic effect on renal function worsening

Ultrasound biomicroscopy and evaluation of the feline iridocorneal angle

Purpose Identify qualitative features and quantitative parameters of the iridocorneal angle in healthy cats using ultrasound biomicroscopy (UBM). Methods Eight cats for a total of 16 eyes, admitted at the Veterinary Teaching Hospital of the University of Camerino for routine procedures were included in this study. All cats included were free from ophthalmic diseases, had a normal intraocular pressure (IOP) pressure and did not undergo pharmacological therapy potentially affecting the IOP. Images and measurements were obtained from all cats using ACCUTOME PLUS UBM device after sedation and topical anesthesia. The following measurements were obtained: HICA (height iridocornel angle), DICA (depth iridocorneal angle), ICA (iridocorneal angle area) e HAC (height anterior chamber). All the data obtained by three sequential measurements from each eye were summarized in mean and standard deviation and subjected to omoscedasticity analysis using Cochrane test. Results In all cats, the UBM examination allowed a full evaluation of the cornea and the scleral corneal junction, the iris, the crystalline and the drainage angle. Mean HICA was 1.43 ± 0.15 mm (C=0.30, α=0.01), mean DICA was 3.05 ± 0.27 mm (C=0.14, α=0.01), mean ICA was 1.83 ± 0.28 mm2 (C=0.28, α=0.01), mean HAC was 3.47 ± 0.12 mm (C=0.24, α=0.01). Conclusion Despite the small sample size, measured data were statistically homogeneous in the population studied. UBM is an easy-to-use method that can be used to study the iridocorneal angle in cats. To the author knowledge, this study provided the first in vivo UBM evaluation in healthy cats

Innovazioni della diagnostica per immagini in oftalmologia felina

Ultrasound biomicroscopy (UBM) is a ultrasound diagnostic method recently introduced in veterinary ophthalmology. The UBM, because of high frequency (48-50Mhz) transducer, allows a detailed view of the structures of anterior Chambre and especially the irido-corneal angle. In this thesis, UBM assessment was performer in anterior chambre of feline healthy eyes. The main purpose of the study was to identify the normal parameters as a potential comparison for diagnosis of disease.The pathology that have the greatest indication for the execution of UBM is the primary open angle glaucoma (POAG)

Innovazioni della diagnostica per immagini in oftalmologia felina

Ultrasound biomicroscopy (UBM) is a ultrasound diagnostic method recently introduced in veterinary ophthalmology. The UBM, because of high frequency (48-50Mhz) transducer, allows a detailed view of the structures of anterior Chambre and especially the irido-corneal angle. In this thesis, UBM assessment was performer in anterior chambre of feline healthy eyes. The main purpose of the study was to identify the normal parameters as a potential comparison for diagnosis of disease.The pathology that have the greatest indication for the execution of UBM is the primary open angle glaucoma (POAG)

Valutazione dell’angolo irido-corneale nell’occhio felino sano mediante ultrasound biomicroscopy

Ultrasound biomicroscopy (UBM) is an ultrasound diagnostic method recently introduced in veterinary ophthalmology. The UBM, because of high frequency (48-50 Mhz) transducer, allows a detailed view of the structures of anterior chamber, especially the irido-corneal angle. In this thesis, UBM assessment was performed in anterior chamber of feline healthy eyes. The main purpose of the study was to identify the normal parameters as a potential comparison for diagnosis of diseases. The pathology that has the greatest indication for the execution of UBM is the primary open angle glaucoma (POAG)

Impact of the SARS-CoV-2 outbreak on pediatric liver transplant recipients residing in Lombardy, Northern Italy.

The novel Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV-2) disease (COVID-19) represents an unprecedented public health issue for the general population and for patients with underlying chronic conditions. Compared to adults, children seem to have a milder course of the disease, with very few requiring medical attention

La civilt\ue0 del latte. Fonti, simboli e prodotti dal Tardoantico al Novecento

Attraverso un percorso interdisciplinare si pubblicano gli atti del convegno nazionale del 2008 svoltosi a Brescia sul latte e i suoi derivati dall'et\ue0 antica al Novecento; un corredo di indici aiuta la consultazione e l'uso multidisciplinare del volumeThe proceedings of the national convention of 2008, in Brescia, about milk and dairy products, are published: the study shows a research, characterized by an interdisciplinary way, from ancient times to the twentieth century: a set of indices also helps the reading and the multidisciplinary stud