Ecdótica y hermenéutica: el problema de la censura en la transmisión de la Llama de San Juan de la Cruz

Aunque los carmelitas han considerado el problema textual de la Llama poco relevante –quizá porque, respecto al Cántico, se ha difundido con variantes menos significativas–, sin embargo, basta un rápido cotejo de la tradición para advertir inmediatamente una transmisión anómala de la Declaración de las canciones que Juan de la Cruz escribió para una dirigida espiritual suya, doña Ana de Peñalosa

Efficacy of European Policies on Rural Landscape: the Case Study of Sardinia (ITALY)

Over the last decades, a large number of developed countries have explicitly recognized the importance of benefits generated from agricultural and rural landscape into their legislation. Since the early '90, preservation and enhancing of rural landscape has played an increasing role also into the Common Agricultural Policy (CAP) promoted by the European Union (EU). More generally, the whole European rural development policy seems to recognize an important role to the keeping of agricultural and rural landscape. The present work is a part of a wider research aimed to identify rational instruments for guidance policies on rural landscape. The specific purpose of this paper is to evaluate efficacy of Sardinian (Italy) regional policies on rural landscape. In particular, the analysis aims to assess "functionality" of policies on rural landscape in programming policy. Results arisen from analysis of Rural Development of this first evaluation are controversial.rural landscape, rural and environmental policies, structural policies, efficacy policies evaluation, Sardinia, Agricultural and Food Policy, Q18, Q28, R59,

L'ANSIA PERIOPERATORIA NEL PAZIENTE PEDIATRICO: UNA SFIDA PER L'ANESTESISTA

L’anestesia e le procedure diagnostiche e/o chirurgiche per le quali essa viene eseguita, possono evocare nel bambino e nei suoi genitori la comparsa di ansia perioperatoria.Ogni esperienza negativa vissuta in tali circostanze puo’ promuovere lo sviluppo di alterazioni comportamentali perioperatorie e di complicanze postoperatorie a breve, medio e lungo termine. L'anestesista deve essere in grado di identificare e prevenire quelle situazioni che un bambino puo’ avvertire come una minaccia o un pericolo, garantendo un anestesia non traumatica e prevenendo lo sviluppo di complicanze postoperatorie ansia-correlate. Al tal fine egli puo’ avvalersi dell’utilizzo di strumenti non farmacologici e/o dell’eventuale somministrazione di farmaci specifici

The DAVAd: A Narrative Tool to Explore the Early Stages of the Adoptive Bond

The DAVAd (the first bond process diary) is a new narrative tool created to accompany the adoptive couple during their trip to the land of the child/children to whom they have been matched. The tool presented is the first to explore what happens, in term of events and emotional experiences, during the first meetings between the parental couple and the child/children. This period is clinically relevant as the ideal is compared with the real. The DAVAd supports the parental couple in focusing on their experiences and their meanings and learning to deal with the complexity related to the bound construction. Moreover, the DAVAd allows the clinical psychologist in detecting and treating, if necessary, the familiar dynamics, favoring the prevention of the distress. A clinical case that utilizes the DAVAd will be presented, to enlighten the way its compilation can be used by researchers and clinicians

Facial dermatoses and use of protective mask during Covid-19 pandemic: A clinical and psychological evaluation in patients affected by moderate-severe atopic dermatitis under treatment with dupilumab

During the SARS-COV-2 pandemic, using face masks became mandatory in many countries. Although evidence suggests that masks can exacerbate several inflammatory skin diseases, few studies focus on their real impact on eczema localized to the face in atopic dermatitis (AD) patients. The aim of this study is to evaluate facial eczema prevalence during pandemic and its psychological impact in AD patients pre-assessed for systemic treatment and/or in therapy with dupilumab. This study includes 71 patients affected by moderate-severe AD, treated with dupilumab at SCDU of Dermatology in Novara, Italy. We calculated the number of subjects with facial involvement in pre- and post-pandemic periods and the related localization trend. We evaluated, in the two groups, clinical and psychological indicators recorded at each visit and the score modifications during the observational period. No statistically significant differences were observed in facial eczema prevalence, between pre- and post-pandemic periods (p = 0.7618) and in facial eczema remission among the two groups (p = 0.1903). In post-pandemic period, psychological scores were significantly lower (DLQI and HADS respectively with p < 0.0001 and p = 0.0025) and the reduction in EASI score during observational period was significantly greater (p = 0.0001). Our analysis revealed a potential protective effect of masks on face eczema, suggesting that they could enhance dupilumab efficacy. Face masks, covering sensitive areas, can positively contribute to mental distress in patients with facial eczema, and being associated with a lower allergic diseases incidence may sustain dupilumab in reducing AD severity

Impacts of moose (Alces alces) at different simulated densities on eco-morphological groups of soil mesofauna

We experimentally tested the impact of browsing, defecation and urination corresponding to four different levels of moose population density on abundance and number of eco-morphological groups of soil mesofauna in a Swedish boreal forest. The study was carried out in three fenced exclosures representing different levels of productivity (from nutrient-rich to nutrient-poor). Moose impact on soil communities was evaluated by analysing abundance, richness and diversity of mesofaunal groups, and by means of a multi-taxa index based on ecomorphological groups, the Biological Soil Quality index (QBS). There was a negative impact of high moose densities on the abundance and richness of soil mesofauna. Furthermore, low-moderate moose densities had a positive impact on abundance and number of eco-morphological groups. We conclude that moose can have a large impact on soil-living mesofauna, and therefore probably soil decomposition processes and biological soil quality, in young boreal forest stands

Intervención social en desastres socionaturales : análisis desde estudiantes de trabajo social de Coquimbo y Atacama en Chile y los desafíos para la eco-formación disciplinar

Objetivo. Conocer las representaciones sociales de estudiantes de trabajo social, respecto de los desastres socio-naturales que ocurren en su territorio y opciones de intervención/gestión social que reconocen. Metodología. Cuantitativa, de diseño estudio de caso. Participaron estudiantes de las regiones de Atacama y Coquimbo en Chile, que han enfrentado DSN recientes como aluviones, terremoto y sequía. Resultados. Los hallazgos dan cuenta del reconocimiento de la influencia antrópica en los desastres a partir del extractivismo, la prevalencia de una noción de naturaleza de tipo ecocéntrica y la importancia de la acción profesional como vía para la reducción del riesgo. Conclusiones. Relevancia de incluir en la formación en trabajo social, eco-saberes teóricos, metodológicos y procedimentales que problematicen la dimensión ética del vínculo sociedad-territorio-naturaleza.Objective: To know the social representations of social work students, regarding the socio-natural disasters that occur in their territory and options for intervention/social management that they recognize. Methodology: Quantitative method, case study design. Students from the Atacama and Coquimbo regions in Chile who have faced recent SND such as floods, earthquakes and droughts participated. Results: The findings show the recognition of the anthropic influence on disasters from extractivism, the prevalence of an eco-centric notion of nature and the importance of professional action as a way to reduce risk.Conclusions: Relevance of including in Social Work training, theoretical, methodological and procedural eco-knowledge that problematizes the ethical dimension of the society-territory-nature link

Non-Natural Linker Configuration in 2,6-Dipeptidyl-Anthraquinones Enhances the Inhibition of TAR RNA Binding/Annealing Activities by HIV-1 NC and Tat Proteins

The HIV-1 nucleocapsid (NC) protein represents an excellent molecular target for the development of antiretrovirals by virtue of its well-characterized chaperone activities, which play pivotal roles in essential steps of the viral life cycle. Our ongoing search for candidates able to impair NC binding/annealing activities led to the identification of peptidylanthraquinones as a promising class of nucleic acid ligands. Seeking to elucidate the inhibition determinants and increase the potency of this class of compounds, we have now explored the effects of chirality in the linker connecting the planar nucleus to the basic side chains. We show here that the non-natural linker configuration imparted unexpected TAR RNA targeting properties to the 2,6-peptidyl-anthraquinones and significantly enhanced their potency. Even if the new compounds were able to interact directly with the NC protein, they manifested a consistently higher affinity for the TAR RNA substrate and their TARbinding properties mirrored their ability to interfere with NC-TAR interactions. Based on these findings, we propose that the viral Tat protein, sharing the same RNA substrate but acting in distinct phases of the viral life cycle, constitutes an additional druggable target for this class of peptidyl-anthraquinones. The inhibition of Tat-TAR interaction for the test compounds correlated again with their TAR-binding properties, while simultaneously failing to demonstrate any direct Tat-binding capabilities. These considerations highlighted the importance of TAR RNA in the elucidation of their inhibition mechanism, rather than direct protein inhibition. We have therefore identified anti-TAR compounds with dual in vitro inhibitory activity on different viral proteins, demonstrating that it is possible to develop multitarget compounds capable of interfering with processes mediated by the interactions of this essential RNA domain of HIV-1 genome with NC and Tat proteins