COVID-19 and Pregnancy: An Updated Review about Evidence-Based Therapeutic Strategies

The COVID-19 pandemic posed a significant challenge for clinicians in managing pregnant women, who were at high risk of virus transmission and severe illness. While the WHO declared in May 2023 that COVID-19 is no longer a public health emergency, it emphasized that it remains a global health threat. Despite the success of vaccines, the possibility of new pandemic waves due to viral mutations should be considered. Ongoing assessment of the safety and effectiveness of pharmacological therapies is crucial in clinical practice. This narrative review summarizes the evidence-based therapeutic strategies for pregnant women with COVID-19, considering over three years of pandemic experience. The review discusses the safety and effectiveness of various drug regimens (antivirals, anticoagulants, corticosteroids, immunoglobulins, monoclonal antibodies, and therapeutic gases) and procedures (prone positioning and extracorporeal membrane oxygenation). Drugs with contraindications, inefficacy during pregnancy, or unknown adverse effects were excluded from our evaluation. The aim is to provide healthcare professionals with a comprehensive guide for managing pregnant women with COVID-19 based on lessons learned from the pandemic outbreak

Comparison of 3D ultrasound and magnetic resonance imaging (MRI) in the diagnosis of Herlyn Werner Wunderlich Syndrome.

no disponibil

Liquid Biopsy in Cervical Cancer: Hopes and Pitfalls

Cervical cancer (CC) is the fourth most common cancer in women worldwide, with about 90% of cancer-related deaths occurring in developing countries. The geographical influence on disease evolution reflects differences in the prevalence of human papilloma virus (HPV) infection, which is the main cause of CC, as well as in the access and quality of services for CC prevention and diagnosis. At present, the most diffused screening and diagnostic tools for CC are Papanicolaou test and the more sensitive HPV-DNA test, even if both methods require gynecological practices whose acceptance relies on the woman’s cultural and religious background. An alternative (or complimentary) tool for CC screening, diagnosis, and follow-up might be represented by liquid biopsy. Here, we summarize the main methodologies developed in this context, including circulating tumor cell detection and isolation, cell tumor DNA sequencing, coding and non-coding RNA detection, and exosomal miRNA identification. Moreover, the pros and cons of each method are discussed, and their potential applications in diagnosis and prognosis of CC, as well as their role in treatment monitoring, are explored. In conclusion, it is evident that despite many advances obtained in this field, further effort is needed to validate and standardize the proposed methodologies before any clinical use

Higher prevalence of chronic endometritis in women with endometriosis: a possible etiopathogenetic link

n/

Improvement rate of patients with severe brain injury during post-acute intensive rehabilitation

Patients with severe acquired brain injury (SABI) may evolve towards different outcomes. The primary aim was to evaluate the clinical evolution of a large population of patients with SABI admitted to post-acute rehabilitation from 2001 to 2016, diagnosed with severe brain injury (GCS ≤ 8) in the acute phase and a coma duration of at least 24 h. The possible changes between the admission time to a post-acute rehabilitation hospital and the discharge time were measured by means of Glasgow Outcome Scale (GOS), Level of Cognitive Functioning (LCF), and Disability Rating Scale (DRS). We also correlated the improvement rate with some sociodemographic and clinical features of the individuals with SABI enrolled. Data of 890 patients were analyzed (54% TBI, length of stay = 162 ± 186 days, GCS = 7.46 ± 1.28); time interval from the SABI (OR = 0.246, CI 95% = 0.181 – 0.333), scores at admission of LCF (OR = 2.243, CI 95% = 1.492 – 3.73), GOS (OR = 0.138, CI 95% = 0.071 – 0.266), DRS (OR = 0.457, CI 95% = 0.330 – 0.632), and etiology (OR = 2.273, CI 95% = 1.676 – 3.084) played a significant role (p < 0.001, explained variance 69.9%) for improving GOS score. Time interval from the SABI to admission in our post-acute rehabilitation ward (OR = 0.300, CI 95% = 0.179 – 0.501, p < 0.001), length of rehabilitation stay (OR = 2.808, CI 95% = 1.694 – 4.653, p < 0.001), and etiology (OR = 1.769, CI 95% = 1.095 – 2.857, p = 0.020) led to a statistically significant improvement in DRS (explained variance 91%). The most significant predictive factors for the outcome of patients with SABI were etiology, time interval from SABI to admission in rehabilitation, and length of rehabilitation stay

Joint document of the SIGiTE-SIM 2013 - Management of hormone replacement therapy in menopausal women [Documento Congiunto SIGiTE-SIM 2013 - Gestione del Trattamento Ormonale Sostitutivo nella donna in menopausa]

none32-mixedDonati Sarti Costante; Lello Stefano; Gallo Mario; Micingrucci Maria; Maffei Silvia; Stomati Massimo; Agostinelli Domenico; Becorpi Annamaria; Nappi Rossella; Nocera Fabio; FiorilloFlavia; Baldi Stefania; Cancellieri Francesco; Leli Pietro; Mapelli Carlo; Cordopatri Alberto; Repetti Fausto; Volpe Annibale; Dessole Salvatore; Lanzone Antonio; CAGNACCI, Angelo; Cicinelli Ettore; Grimaldi Eva; Guaschino Secondo; Maffei Silvia; Massobrio Massimo; Melis Gian Benedetto; Omodei Umberto; Paoletti AnnaMaria; Sciacchitano Salvatore; Venturoli Stefano; Villa PaolaDonati Sarti, Costante; Lello, Stefano; Gallo, Mario; Micingrucci, Maria; Maffei, Silvia; Stomati, Massimo; Agostinelli, Domenico; Becorpi, Annamaria; Nappi, Rossella; Nocera, Fabio; Fiorilloflavia, ; Baldi, Stefania; Cancellieri, Francesco; Leli, Pietro; Mapelli, Carlo; Cordopatri, Alberto; Repetti, Fausto; Volpe, Annibale; Dessole, Salvatore; Lanzone, Antonio; Cagnacci, Angelo; Cicinelli, Ettore; Grimaldi, Eva; Guaschino, Secondo; Maffei, Silvia; Massobrio, Massimo; Melis Gian, Benedetto; Omodei, Umberto; Paoletti, Annamaria; Sciacchitano, Salvatore; Venturoli, Stefano; Villa, Paol