Prevention Research Center for Healthy Neighborhoods

https://collected.jcu.edu/celebration_2023/1002/thumbnail.jp

The use of Platelet-Rich Fibrin in oral surgery

Department of Oral and Maxillo-facial Surgery and Oral Implantology Arsenie Gutan, Nicolae Testemitanu State University of Medicine and Pharmacy of the Republic of MoldovaIntroduction. The blood supply and growth factors are essential factors in postoperative healing. Platelet-Rich Fibrin (PRF) is a relatively new concept of natural tissue regeneration, which is widely applied in oral and maxillofacial surgery. Its’ advantage consists in increased concentration of autogenous growth factors. It may be used alone or in combination with grafting materials, in order to facilitate wound healing, bone growth and tissue maturation after different types of surgeries. Aim of the study. The aim of this study is to analyze the effect of Platelet- Rich Fibrin (PRF) regarding specific clinical cases, in patients with different diagnosis. Material and methods. A clinical study has been performed in four patients with different clinical diagnosis: wound dehiscence, oro-antral communication, mandibular cyst, free gingival graft from palate. These patients were treated using standard treatment protocols and the Platelet- Rich Fibrin membranes as biological seals with and without grafting materials. Results. The use of PRF membranes as biological seal after soft tissue grafting as well as tooth extraction with cystectomy appeared to be stable and protected the socket and grafting material during healing. The same effect was observed after closing of oro-antral communication. Furthermore, the application of PRF membranes seems to promote tissue healing in case of postoperative wound dehiscence. Conclusions. The use of PRF membranes has a positive effect upon soft and hard tissue healing. Moreover, it seems to facilitate the healing process and decrease the risk of postoperative complications

The role of Platelet - Rich Fibrin technolog in oral wound healing

Department of Oral and Maxillo-facial Surgery Arsenie Gutan, Nicolae Testemitanu State University of Medicine and Pharmacy, Chisinau, Republic of Moldova, The 8th International Medical Congress for Students and Young Doctors, September 24-26, 2020Introduction: Unlike some of his counterparts in the animal kingdom, man does not have the possibility of accelerated healing and regeneration, and over the years, attempts have been made to find ways to avoid this restriction. The blood supply and growth factors are essential components in postoperative healing. Platelet-Rich Fibrin (PRF) is a relatively new concept of natural tissue regeneration, which is widely applied in oral and maxillofacial surgery. Developed by Joseph Choukroun, in 2001, Nice, France, it was firstly used as an enhancer of tissue regeneration for patients with diabetic ulcer. Subsequently, it has spread in other areas and nowadays the PRF technique is a key-procedure in oral and plastic surgery, periodontal surgery, prosthetics, and other domains. Its’ advantage consists in increased concentration of autogenous growth factors, which are spread during ≥7 days. It may be used alone or in combination with grafting materials, in order to facilitate wound healing and tissue maturation after different types of surgeries. Aim of the study. The aim of this study is to analyze the effect of Platelet- Rich Fibrin (PRF) regarding specific clinical cases, in patients with different diagnosis. Materials and methods.. This clinical study has been performed in a series of 20 patients with different clinical diagnosis: wound dehiscence (3 patients), oro-antral communication (5 patients), mandibular cystectomy augmentation (3 patients), free gingival graft from palate (2 patients), sinus lifting procedure (4 patients), postextractional socket preservation (3 patients). These patients were treated using standard treatment protocols and the Platelet- Rich Fibrin membranes as biological seals with and without grafting materials. Results. The use of PRF membranes as a biological seal after soft tissue grafting had the role of isolating the wound from the oral cavity, reducing pain syndrome by limiting the direct exposure of the wound to traumatic factors. In the case of maintaining the post-extraction socket and cystectomy using PRF membranes, the level of the alveolar ridge was maintained, and the quality of the newly formed bone was good enough for the subsequent implant insertion. An increased regeneration effect was observed after the closure of oro-antral communications of different dimensions. Moreover, the application of PRF membranes appears to promote tissue healing in case of postoperative wound dehiscence. Conclusions. By strictly adhering to the protocol, the PRF can be applied in various clinical situations, and the lack of long and short-term complications denotes the positive impact of the technology on the regeneration of oral wounds

Kadar Bahan Organik dan Beberapa Sifat Fisik Tanah di Bawah Tegakan Tusam

ETTE PANUS (M 111 07 901). Kadar Bahan Organik dan Beberapa Sifat\ud Fisik Tanah di Bawah Tegakan Tusam (Pinus merkusii Jungh. et de Vriese),\ud Mahoni (Swietenia macrophylla King), Akasia (Acacia auriculiformis Cunn.\ud ex Benth) dan Puspa (Schima wallichii Korth) di Hutan Pendidikan Bengo-\ud Bengo di bawah bimbingan Baharuddin Nurkin dan H. Anwar Umar.\ud Penelitian ini bertujuan untuk mengetahui pengaruh tegakan murni dari\ud tusam, mahoni, akasia dan puspa terhadap sifat-sifat fisik tanah (kerapatan\ud bongkah, porositas tanah, infiltrasi dan permeabilitas tanah) serta kandungan\ud bahan organik tanah, mengetahui pengaruh bahan organik terhadap kerapatan\ud bongkah, porositas tanah, infiltrasi dan permeabilitas.\ud Penelitian ini dilaksanakan selama tiga bulan, dimulai dari bulan April\ud sampai dengan bulan Juni 2011 yang berlokasi di hutan pendidikan Bengo-bengo\ud dan analisis laboratorium dilaksanakan di Laboratorium Jurusan Ilmu Tanah\ud Fakultas Pertanian Universitas Hasanuddin. Variabel yang dianalisis adalah\ud kerapatan bongkah, porositas, infiltrasi, permeabilitas dan kandungan bahan\ud organik (karbon) tanah.\ud Data dikumpulkan dari masing-masing tegakan hutan tanaman tusam,\ud mahoni, akasia dan puspa kemudian dianalisis di laboratorium, data hasil analisis\ud tersebut kemudian dianalisis dengan menggunakan analisis ragam dan uji F untuk\ud mengetahui pengaruh tegakan terhadap sifat-sifat tanah, sedangkan untuk\ud mengetahui pengaruh bahan organik terhadap kerapatan bongkah, porositas,\ud infiltrasi dan permeabilitas digunakan persamaan analisis regresi linear sederhana.\ud Hasil penelitian menunjukkan bahwa tegakan tusam, mahoni, akasia dan\ud puspa memberi pengaruh tidak nyata terhadap kerapatan bongkah, porositas,\ud infiltrasi, permeabilitas dan kandungan bahan organik (karbon) tanah.\ud Selanjutnya, bahan organik dari tegakan tusam, mahoni, akasia dan puspa\ud menurunkan kerapatan bongkah dan dan meningkatkan porositas, infiltrasi dan\ud permeabilitas tanah

Formulation and in Vitro Evaluation of Niacinloaded Nanoparticles to Reduce Prostaglandin Mediated Vasodilatory Flushing

OBJECTIVE: Niacin, activating G-protein coupled receptor (GPR) 109A, stimulates release of vasodilatory prostaglandins (PGs) such as PGE2 which can elicit niacin-associated flushing side effects. Poly-lactic-coglycolic acid (PLGA) and poly-lactic acid (PLA) are used in nanoparticle (NP) drug delivery to reduce adverse effects and modulate drug release. Our study evaluated the in vitro effects of niacin-loaded PLGA or PLA-NPs on PGE2 expression in whole human blood as a model for niacin-induced flushing. MATERIALS AND METHODS: NPs were formulated using a solvent evaporation process and characterized by size, polydispersity, zeta potential, drug entrapment, morphology, and drug release. NP in vitro effects on PGE2 release were measured via ELISA analysis. RESULTS: PLGA-NPs demonstrated the lowest NP size (66.7 ± 0.21 nm) with the highest zeta potential and percent drug entrapment (42.00 ± 1.62 mV and 69.09 ± 0.29%, respectively) when compared to PLA-NPs (130.4 ± 0.66 nm, 27.96 ± 0.18 mV, 69.63 ± 0.03 %, respectively). In vitro release studies showed that PLGA-NPs underwent significant reductions in cumulative drug release when compared to PLA-NPs (p \u3c 0.05). Furthermore, when compared to plain niacin, PLGA-NPs significantly reduced in vitro PGE2 release (p \u3c 0.05). CONCLUSIONS: These results support the use of PLGA-NPs as a novel method of delivery for reducing niacin-associated flushing

Pharmacy Student Self-Testing as a Predictor of Examination Performance

Objectives. To determine if student self-testing improves performance during a doctor of pharmacy course. Methods. Students were given access to online quizzes with a large pool of randomly selected questions specific to upcoming examination content. Quizzes were electronically scored immediately upon completion and students were provided corrective feedback. Results. Examination scores following implementation of the practice quizzes were significantly higher in all but the last testing period. The upper fiftieth percentile of students scored higher on both the practice quizzes and subsequent examinations in all but the fourth testing period. Conclusions. Providing pharmacy students with self-testing opportunities could increase their retention of course material and provide feedback to both students and educators regarding learning, as well as provide students with a measure of their metacognition

Celecoxib or Diclofenac Hepatic Status in the Presence or Absence of Rebamipide

OBJECTIVE: Utilization of nonsteroidal anti-inflammatory drugs (NSAIDs), such as diclofenac, can produce gastrointestinal ulceration. Thus, cyclooxygenase-2-selective inhibitors, such as celecoxib, and protective agents (e.g. rebamipide) have been employed to alleviate harmful NSAID effects. This study sought to explore the influence of rebamipide on the hepatic outcomes following administration of two commonly prescribed NSAIDs. MATERIALS AND METHODS: Rats were given either vehicle or rebamipide (30 mg/kg) orally twice daily for two days, then on the third day respective groups were dosed with either vehicle, celecoxib (40 mg/kg), or diclofenac (10 mg/kg) in addition to a respective dose of vehicle or rebamipide. Livers were collected on day 4 following euthanasia. Hepatic tissue was examined via histopathology and assayed for oxidative stress and specific NSAID concentration. RESULTS: The liver sections were found to be free from structural changes. Oxidative stress biomarkers, reduced glutathione and malondialdehyde, were discovered to be unaltered among the groups tested. The hepatic NSAID concentrations were not significantly affected by the presence of rebamipide. CONCLUSIONS: The concomitant administration of rebamipide does not influence the hepatic condition of rats administered either celecoxib or diclofenac at the dosages and over the time course examined

Ungkapan tradisional sebagai sumber informasi kebudayaan daerah Kalimantan Barat

Buku ini berisi tentang ungkapan tradisional sebagai sumber informasi kebudayaan daerah kalimantan barat yang meliputi ungkapan tradisional suku daya suhaid dan daya kendayan

A Subgroup Analysis of the Impact of Self-testing Frequency on Examination Scores in a Pathophysiology Course

Objective: To determine if the frequency of self-testing of course material prior to actual examination improves examination scores, regardless of the actual scores on the self-testing. Methods: Practice quizzes were randomly generated from a total of 1342 multiple-choice questions in pathophysiology and made available online for student self-testing. Intercorrelations, 2-way repeated measures ANOVA with post hoc tests, and 2-group comparisons following rank ordering, were conducted. Results: During each of 4 testing blocks, more than 85% of students took advantage of the self-testing process for a total of 7042 attempts. A consistent significant correlation (p≤0.05) existed between the number of practice quiz attempts and the subsequent examination scores. No difference in the number of quiz attempts was demonstrated compared to the first testing block. Exam scores for the first and second testing blocks were both higher than those for third and fourth blocks. Conclusion: Although self-testing strategies increase retrieval and retention, they are uncommon in pharmacy education. The results suggested that the number of self-testing attempts alone improved subsequent examination scores, regardless of the score for self-tests