Социо-эколого-экономическая политика внедрения химико-технологических инноваций

Article shows necessity of state regulation in sphere of industrial production for the purpose of maintenance of a socio-ecologo-economic orientation of an investment policy on introduction of himiko-technological innovations. Article is written in respect of preparation for the international conference devoted to a sustainable development of «Rio+20».Рассматривается необходимость усиления роли государства в сфере промышленного про-изводства с целью обеспечения социо-эколого-экономической направленности инвестиционной политики по внедрению химико-технологических инноваций. Статья написана в плане подготовки к международной конференции «Рио+20», посвященной устойчивому развитию

Верификация ганглиоглиомы ассоциированной с нейрональной гетеротопией у взрослого пациента без эпилепсии с применением мультимодального подхода к визуализации

Gangliogliomas are known to be rare and mainly slow-growing benign primary central nervous system tumors, most frequently occurring in children and young adults. They are the most common epilepsy-associated tumors, which frequent location is the temporal lobe. Surgery often seems to be the best approach in controlling seizures in such patients. This paper deals with a rare case of ganglioglioma in a young adult patient with a temporal lobe tumor associated with neuronal heterotopy of white matter, but without epilepsy. Long-term dynamic observation including in-depth clinical, electroencephalographic, radiologic, and postsurgical histologic examination confirmed the documented neoplastic process without any manifestation of seizures over ten years. Surgical intervention was based on the results of a multimodal radiological examination, which demonstrated the presence of neoplasm in the structure of the pathological substrate of unclear etiology. Известно, что ганглиоглиомы являются редкими, и в основном, медленно растущими доброкачественными первичными опухолями центральной нервной системы, чаще всего встречающимися у детей и молодых людей. Это наиболее распространенные опухоли, ассоциированные с эпилепсией, часто локализующиеся в височной доле. Хирургия часто кажется лучшим подходом к контролю приступов у таких пациентов. В данной статье рассматривается редкий случай ганглиоглиомы локализованной в височной доле, ассоциированной с нейрональной гетеротопией белого вещества у молодого пациента, но без эпилепсии. Длительное динамическое наблюдение, включающее углубленное клиническое, электроэнцефалографическое, радиологическое и послеоперационное гистологическое исследование, документально подтвердили наличие неопластического процесса без приступов в течение десяти лет. Хирургическое вмешательство основывалось на результатах комплексного радиологического исследования, продемонстрировавшего наличие неоплазмы в структуре патологического субстрата неясной этиологии.

Indiscriminate Males: Mating Behaviour of a Marine Snail Compromised by a Sexual Conflict?

Background: In promiscuous species, male fitness is expected to increase with repeated matings in an open-ended fashion (thereby increasing number of partners or probability of paternity) whereas female fitness should level out at some optimal number of copulations when direct and indirect benefits still outweigh the costs of courtship and copulation. After this fitness peak, additional copulations would incur female fitness costs and be under opposing selection. Hence, a sexual conflict over mating frequency may evolve in species where females are forced to engage in costly matings. Under such circumstance, if females could avoid male detection, significant fitness benefits from such avoidance strategies would be predicted. Methodology/Principal Findings: Among four Littorina species, one lives at very much higher densities and has a longer mating season than the other three species. Using video records of snail behaviour in a laboratory arena we show that males of the low-density species discriminate among male and female mucous trails, trailing females for copulations. In the high-density species, however, males fail to discriminate between male and female trails, not because males are unable to identify female trails (which we show using heterospecific females), but because females do not, as the other species, add a gender-specific cue to their trail. Conclusions/Significance: We conclude that there is likely a sexual conflict over mating frequency in the high-densit

Bespoke library docking for 5-HT2A receptor agonists with antidepressant activity

There is considerable interest in screening ultralarge chemical libraries for ligand discovery, both empirically and computationally1-4. Efforts have focused on readily synthesizable molecules, inevitably leaving many chemotypes unexplored. Here we investigate structure-based docking of a bespoke virtual library of tetrahydropyridines-a scaffold that is poorly sampled by a general billion-molecule virtual library but is well suited to many aminergic G-protein-coupled receptors. Using three inputs, each with diverse available derivatives, a one pot C-H alkenylation, electrocyclization and reduction provides the tetrahydropyridine core with up to six sites of derivatization5-7. Docking a virtual library of 75 million tetrahydropyridines against a model of the serotonin 5-HT2A receptor (5-HT2AR) led to the synthesis and testing of 17 initial molecules. Four of these molecules had low-micromolar activities against either the 5-HT2A or the 5-HT2B receptors. Structure-based optimization led to the 5-HT2AR agonists (R)-69 and (R)-70, with half-maximal effective concentration values of 41 nM and 110 nM, respectively, and unusual signalling kinetics that differ from psychedelic 5-HT2AR agonists. Cryo-electron microscopy structural analysis confirmed the predicted binding mode to 5-HT2AR. The favourable physical properties of these new agonists conferred high brain permeability, enabling mouse behavioural assays. Notably, neither had psychedelic activity, in contrast to classic 5-HT2AR agonists, whereas both had potent antidepressant activity in mouse models and had the same efficacy as antidepressants such as fluoxetine at as low as 1/40th of the dose. Prospects for using bespoke virtual libraries to sample pharmacologically relevant chemical space will be considered

Regional adaptation defines sensitivity to future ocean acidification

Physiological responses to temperature are known to be a major determinant of species distributions and can dictate the sensitivity of populations to global warming. In contrast, little is known about how other major global change drivers, such as ocean acidification (OA), will shape species distributions in the future. Here, by integrating population genetics with experimental data for growth and mineralization, physiology and metabolomics, we demonstrate that the sensitivity of populations of the gastropod Littorina littorea to future OA is shaped by regional adaptation. Individuals from populations towards the edges of the natural latitudinal range in the Northeast Atlantic exhibit greater shell dissolution and the inability to upregulate their metabolism when exposed to low pH, thus appearing most sensitive to low seawater pH. Our results suggest that future levels of OA could mediate temperature-driven shifts in species distributions, thereby influencing future biogeography and the functioning of marine ecosystems

K∗(892)0K^{*}(892)^0 meson production in inelastic p+p interactions at 40 and 80 GeV ⁣/ ⁣c\text{ GeV }\!/\!c beam momenta measured by NA61/SHINE at the CERN SPS

Measurements of K∗(892)0 resonance production via its K+π− decay mode in inelastic p+p collisions at beam momenta 40 and 80 GeV /c (sNN−−−−√=8.8 and 12.3 GeV ) are presented. The data were recorded by the NA61/SHINE hadron spectrometer at the CERN Super Proton Synchrotron. The template method was used to extract the K∗(892)0 signal. Transverse momentum and rapidity spectra were obtained. The mean multiplicities of K∗(892)0 mesons were found to be (35.1±1.3(stat)±3.6(sys))⋅10−3 at 40 GeV /c and (58.3±1.9(stat)±4.9(sys))⋅10−3 at 80 GeV /c. The NA61/SHINE results are compared with the Epos1.99 and Hadron Resonance Gas models as well as with world data. The transverse mass spectra of K∗(892)0 mesons and other particles previously reported by NA61/SHINE were fitted within the Blast-Wave model. The transverse flow velocities are close to 0.1–0.2 of the speed of light and are significantly smaller than the ones determined in heavy nucleus-nucleus interactions at the same beam momenta

Measurements of K0^{0}S_{S}, Λ , and Λˉ\bar{Λ} production in 120 GeV / c p + C interactions

This paper presents multiplicity measurements of K0S, Λ, and ¯Λ produced in 120  GeV/c proton-carbon interactions. The measurements were made using data collected at the NA61/SHINE experiment during two different periods. Decays of these neutral hadrons impact the measured π+, π−, p and ¯p multiplicities in the 120  GeV/c proton-carbon reaction, which are crucial inputs for long-baseline neutrino experiment predictions of neutrino beam flux. The double-differential multiplicities presented here will be used to more precisely measure charged-hadron multiplicities in this reaction, and to reweight neutral hadron production in neutrino beam Monte Carlo simulations

KS0K_S^0 meson production in inelastic p+p interactions at 31, 40 and 80 GeV/c beam momentum measured by NA61/SHINE at the CERN SPS

Measurements of $K_S^0$ meson production via its $\pi^{+} \pi^{-}$ decay mode in inelastic $\textit{p+p}$ interactions at incident projectile momenta of 31, 40 and 80 GeV/$c$ ($\sqrt{s_{NN}}=7.7, 8.8$ and $12.3$ GeV, respectively) are presented. The data were recorded by the NA61/SHINE spectrometer at the CERN Super Proton Synchrotron. Double-differential distributions were obtained in transverse momentum and rapidity. The mean multiplicities of $K_S^0$ mesons were determined to be $(5.95 \pm 0.19 (stat) \pm 0.22 (sys)) \times 10^{-2}$ at 31 GeV/$c$, $(7.61 \pm 0.13 (stat) \pm 0.31 (sys)) \times 10^{-2}$ at 40 GeV/$c$ and $(11.58 \pm 0.12 (stat) \pm 0.37 (sys)) \times 10^{-2}$ at 80 GeV/$c$. The results on $K^{0}_{S}$ production are compared with model calculations (Epos1.99, SMASH 2.0 and PHSD) as well as with published data from other experiments.Comment: arXiv admin note: substantial text overlap with arXiv:2106.0753

Two-pion femtoscopic correlations in Be+Be collisions at sNN=16.84\sqrt{s_{\text {NN}}} = 16.84 GeV measured by the NA61/SHINE at CERN

This paper reports measurements of two-pion femtoscopic correlations in Be+Be collisions at a beam momentum of 150A GeV/c (energy available in the center- of-mass system for nucleon pair $\sqrt{s_{\text {NN}}} = 16.84$ GeV) by the NA61/SHINE experiment at the CERN SPS accelerator. The obtained momentum space correlation functions can be well described by a Lévy distributed source model. The transverse mass dependence of the Lévy source parameters is presented, and their possible theoretical interpretations are discussed. The results show that the Lévy exponent α is approximately constant as a function of mT , and far from both the Gaussian case of α = 2 or the conjectured value at the critical end- point, α = 0.5. The radius scale parameter R shows a slight decrease in $m_T$ , which can be explained as a signature of transverse flow. Finally, an approximately constant trend of the intercept parameter λ as a function of $m_T$ was observed, similar to previous NA44 S + Pb results (obtained with a Gaussian approximation, but unlike RHIC results)

Measurement of Hadron Production in π−\pi^--C Interactions at 158 and 350 GeV/c with NA61/SHINE at the CERN SPS

We present a measurement of the momentum spectra of $\pi^\pm$, K$^\pm$, p$^\pm$, $\Lambda$, $\bar{\Lambda}$ and K$^{0}_{S}$ produced in interactions of negatively charged pions with carbon nuclei at beam momenta of 158 and 350 GeV/c. The total production cross sections are measured as well. The data were collected with the large-acceptance spectrometer of the fixed target experiment NA61/SHINE at the CERN SPS. The obtained double-differential $p$-$p_T$ spectra provide a unique reference data set with unprecedented precision and large phase-space coverage to tune models used for the simulation of particle production in extensive air showers in which pions are the most numerous projectiles