On the existence of young embedded clusters at high Galactic latitude

Careful analyses of photometric and star count data available for the nine putative young clusters identified by Camargo et al. (2015, 2016) at high Galactic latitudes reveal that none of the groups contain early-type stars, and most are not significant density enhancements above field level. 2MASS colours for stars in the groups match those of unreddened late-type dwarfs and giants, as expected for contamination by (mostly) thin disk objects. A simulation of one such field using only typical high latitude foreground stars yields a colour-magnitude diagram that is very similar to those constructed by Camargo et al. (2015, 2016) as evidence for their young groups as well as the means of deriving their reddenings and distances. Although some of the fields are coincident with clusters of galaxies, one must conclude that there is no evidence that the putative clusters are extremely young stellar groups.Comment: Accepted for publication (MNRAS

The spreadsheet paradigm: a basis for powerful and accessible programming

This paper takes a cognition-centric approach for programming languages. It promotes the spreadsheet paradigm, with two concrete goals. First, it calls for the design and implementation of several language features to enhance the expressiveness of spreadsheet programming. Second, it describes a plan for rigorous empirical studies to retain the learnability of spreadsheet programming

Wind Circulation in Selected Rotating Magnetic Early-B Stars

The rotating magnetic B stars have oblique dipolar magnetic fields and often anomalous helium and metallic compositions. These stars develop co-rotating torus-shaped clouds by channelling winds from their magnetic poles to an anchored planar disk over the magnetic equator. The line absorptions from the cloud can be studied as the complex rotates and periodically occults the star. We describe an analysis of the clouds of four stars (HD184927, beta Cep, sigma Ori E, and HR6684). From line synthesis models, we find that the metallic compositions are spatially uniform over the stars' surfaces. Next, using the Hubeny CIRCUS code, we demonstate that periodic UV continuum fluxes can be explained by the absorption of low-excitation lines. The analysis also quantifies the cloud temperatures, densities, and turbulences, which appear to increase inward toward the stars. The temperatures range from about 12,000K for the weak Fe lines up to temperatures of 33,000K for N V absorptions, which is in excess of temperatures expected from radiative equilibrium. The spectroscopic hallmark of this stellar class is the presence of strong C IV and N V resonance line absorptions at occultation phases and of redshifted emissions at magnetic pole-on phases. The emissions have characteristics which seem most compatible with the generation of high-energy shocks at the wind-cloud interface, as predicted by Babel.Comment: 19 pages, Latex plus 6 figures A&A single-spaced, accepted by Astronomy & Astrophysics. Files available by ftp at nobel.stsci.edu/pub/aapaper

Progress in cancer survival, mortality, and incidence in seven high-income countries 1995–2014 (ICBP SURVMARK-2): a population-based study

© 2019 World Health Organization Background: Population-based cancer survival estimates provide valuable insights into the effectiveness of cancer services and can reflect the prospects of cure. As part of the second phase of the International Cancer Benchmarking Partnership (ICBP), the Cancer Survival in High-Income Countries (SURVMARK-2) project aims to provide a comprehensive overview of cancer survival across seven high-income countries and a comparative assessment of corresponding incidence and mortality trends. Methods: In this longitudinal, population-based study, we collected patient-level data on 3·9 million patients with cancer from population-based cancer registries in 21 jurisdictions in seven countries (Australia, Canada, Denmark, Ireland, New Zealand, Norway, and the UK) for seven sites of cancer (oesophagus, stomach, colon, rectum, pancreas, lung, and ovary) diagnosed between 1995 and 2014, and followed up until Dec 31, 2015. We calculated age-standardised net survival at 1 year and 5 years after diagnosis by site, age group, and period of diagnosis. We mapped changes in incidence and mortality to changes in survival to assess progress in cancer control. Findings: In 19 eligible jurisdictions, 3 764 543 cases of cancer were eligible for inclusion in the study. In the 19 included jurisdictions, over 1995–2014, 1-year and 5-year net survival increased in each country across almost all cancer types, with, for example, 5-year rectal cancer survival increasing more than 13 percentage points in Denmark, Ireland, and the UK. For 2010–14, survival was generally higher in Australia, Canada, and Norway than in New Zealand, Denmark, Ireland, and the UK. Over the study period, larger survival improvements were observed for patients younger than 75 years at diagnosis than those aged 75 years and older, and notably for cancers with a poor prognosis (ie, oesophagus, stomach, pancreas, and lung). Progress in cancer control (ie, increased survival, decreased mortality and incidence) over the study period was evident for stomach, colon, lung (in males), and ovarian cancer. Interpretation: The joint evaluation of trends in incidence, mortality, and survival indicated progress in four of the seven studied cancers. Cancer survival continues to increase across high-income countries; however, international disparities persist. While truly valid comparisons require differences in registration practice, classification, and coding to be minimal, stage of disease at diagnosis, timely access to effective treatment, and the extent of comorbidity are likely the main determinants of patient outcomes. Future studies are needed to assess the impact of these factors to further our understanding of international disparities in cancer survival. Funding: Canadian Partnership Against Cancer; Cancer Council Victoria; Cancer Institute New South Wales; Cancer Research UK; Danish Cancer Society; National Cancer Registry Ireland; The Cancer Society of New Zealand; National Health Service England; Norwegian Cancer Society; Public Health Agency Northern Ireland, on behalf of the Northern Ireland Cancer Registry; The Scottish Government; Western Australia Department of Health; and Wales Cancer Network

An examination of the long-term business value of investments in information technology

In this paper, we examine the effects of investments in Information Technology (IT) on the long term business values of organizations. The regression discontinuity design is used in this research to examine eight hundred and ten IT investment announcements collected from the period 1982–2007. Our results found that press releases can affect the market value of a firm by possibly providing investors with a better idea of a firm’s current and future operations and strategy. On the other hand, these press releases also appear to attract more transient investors. The attraction of transient investors likely suggests the market believes the IT investing firm is serious about its potential for growth and expansion

The histology of ovarian cancer: worldwide distribution and implications for international survival comparisons (CONCORD-2)

Objective Ovarian cancers comprise several histologically distinct tumour groups with widely different prognosis. We aimed to describe the worldwide distribution of ovarian cancer histology and to understand what role this may play in international variation in survival. Methods The CONCORD programme is the largest population-based study of global trends in cancer survival. Data on 681,759 women diagnosed during 1995â\u80\u932009 with cancer of the ovary, fallopian tube, peritoneum and retroperitonum in 51 countries were included. We categorised ovarian tumours into six histological groups, and explored the worldwide distribution of histology. Results During 2005â\u80\u932009, type II epithelial tumours were the most common. The proportion was much higher in Oceania (73.1%), North America (73.0%) and Europe (72.6%) than in Central and South America (65.7%) and Asia (56.1%). By contrast, type I epithelial tumours were more common in Asia (32.5%), compared with only 19.4% in North America. From 1995 to 2009, the proportion of type II epithelial tumours increased from 68.6% to 71.1%, while the proportion of type I epithelial tumours fell from 23.8% to 21.2%. The proportions of germ cell tumours, sex cord-stromal tumours, other specific non-epithelial tumours and tumours of non-specific morphology all remained stable over time. Conclusions The distribution of ovarian cancer histology varies widely worldwide. Type I epithelial, germ cell and sex cord-stromal tumours are generally associated with higher survival than type II tumours, so the proportion of these tumours may influence survival estimates for all ovarian cancers combined. The distribution of histological groups should be considered when comparing survival between countries and regions