19 research outputs found
Canine biphasic synovial sarcoma: case report and immunohistochemical characterization
The clinical, radiological and pathologic features of a biphasic synovial sarcoma in the left elbow joint of a two-year-old male Rottweiler are presented. The tumor showed positive immunoreactivity for vimentin, Epithelial Membrane Antigen (EMA), p53 and PCNA, while it was negative for the cytokeratin used, S-100, Rb and p21. Immunohistochemistry for EMA allowed the identification of epithelioid components of synovial sarcoma, and may, therefore, contribute in establishing a diagnosis of biphasic synovial sarcoma. Intratumoral variation in PCNA immunoreactivity was minimal, indicating that the various tumor components proliferate at more or less similar rates. Overall, the characterized immunohistochemical profile for canine synovial sarcoma, not defined previously, may provide clues to the histogenesis of the phenotypically mesenchymal and epithelial elements of the tumor, and may be of value in the differential diagnosis of challenging cases, decreasing the risk of under- and mis-diagnosis. Although more cases need to be studied to determine whether there is a consistent pattern of immunostaining in canine synovial sarcoma, its potential significance is discussed in relation to the histogenesis, molecular pathology and differential diagnosis of canine synovial sarcoma
Extensive En block resection and adjunctive chemotherapy of a canine primary rib osteosarcoma
The management of a large rib osteosarcoma in a two-year-old neutered male Golden Retriever is reported. The tumour was initially misdiagnosed as a chondrosarcoma following incisional biopsy. Extensive en bloc resection and chest wall reconstruction with propylene mesh was performed, and carboplatin was administered postoperatively. Approximately 270 days after surgery there was no evidence of tumour recurrence and the patient was disease free
Multilobular tumour of the caudal cranium causing severe cerebral and cerebellar compression in a dog
Multilobular tumour of bone (MTB) is an uncommon tumour and is usually located in the skull. A 13-year-old mixed breed dog was presented with a two-week history of progressively worsening vestibular dysfunction and cognitive abnormalities; it appeared demented and showed asymmetric ataxia and hypermetria of all limbs. The owner opted to have the animal euthanised. Necropsy revealed a large mass occupying the right occipital, parietal and temporal bones, severely compressing the cerebellum and the right occipital lobe. Histologically, it was characterised by the presence of multiple lobules containing osteoid or cartilage and separated by fibrous septae, features typical of MTB. Lung metastases were evident. To our knowledge, this is the first report of an MTB causing both severe cerebral and cerebellar compression and the second detailed report of an MTB of the occipital bone. MTB should be included in the differential diagnosis of bone tumours as well as in cases with central vestibular disease
Illthrift in Suckling Lambs Secondary to Umbilical Infections and Possible Implication of Cryptosporidiosis as a Risk Factor
Illthrift was observed in 20/60 lambs aged 40–45 days in a dairy sheep flock in Greece. Cryptosporidiosis had been diagnosed and successfully treated with halofuginone lactate a month earlier. Parasitological examinations were negative for endoparasites while hematology and biochemistry were unremarkable. Necropsy of 5 lambs revealed lung and liver abscessation, presumably secondary to umbilical infections due to poor farm hygiene, though umbilical lesions were not observed. No new cases were observed following treatment of the umbilicus of newborn lambs with chlorexidine. Although umbilical infections are common, this is the first reported case of illthrift in lambs attributed to umbilical infection; illthrift may be the only clinical manifestation of such infections. The prior presence of cryptosporidiosis may have contributed to the severity of the infection through the reduction of local immunity. Recognition of this possibly underdiagnosed or underappreciated condition may improve medical, production, and welfare standards in the sheep industry
Unusual gross presentation of sarcocystis-like pectoral muscle lymphoma attributed to Marek’s disease in a backyard chicken
Marekʼs disease–induced lymphomas of skeletal muscle are rarely reported in chickens. Three mixed-breed, adult backyard chickens, which belonged to a flock with a previous history of anorexia, depression, ruffled feathers, whitish diarrhea, weight loss and death, were submitted for postmortem examination and diagnostic testing. Grossly, 2 birds had moderate pectoral atrophy, whereas the remaining chicken had numerous white, rice-grain sized foci distributed throughout the pectoral musculature. Severe proventricular wall thickening was observed in all 3 chickens and moderate intestinal Ascaridia spp. parasitism was diagnosed in 2 of the birds. Microscopically, the peripheral nerves, cerebrum, proventriculus, and pectoral musculature were severely infiltrated by mononuclear pleomorphic cells. Formalin-fixed, paraffin-embedded tissues from all 3 chickens were polymerase chain reaction positive for Marekʼs disease virus. A diagnosis of Marekʼs disease was based on the combined necropsy, histopathology, and polymerase chain reaction findings. This article describes the unusual gross presentation of rice-grain sized and shaped lymphomas in the pectoral musculature of chickens caused by Marekʼs disease.Facultad de Ciencias Veterinaria
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A retrospective study of pigeon herpesviral infection in domestic pigeons in California (1991-2014) and literature review.
We characterized naturally occurring pigeon herpesvirus (PiHV; Columbid alphaherpesvirus 1) infection in domestic pigeons in California. We retrieved and analyzed 62 pathology reports produced between 1991 and 2014 at the California Animal Health and Food Safety Laboratory System. In 56 of the cases, the diagnosis of PiHV infection was established based on histopathology, either alone (44 cases) or combined with virus isolation (VI; 8), transmission electron microscopy (TEM; 3), or PCR (1); in the remaining 6 cases, the diagnosis was established based on VI (5 cases) or TEM (1) alone. PiHV infection affected 1 system in 34, 2 in 16, and ≥3 systems in 6 cases; data were not available for the remaining 6 cases. Most commonly affected was the digestive system (55 cases), followed by the respiratory tract (5) and lymphoid system (2). The liver (39 cases), crop (17), and esophagus (14) were the organs affected most commonly. Many affected cells often bore single eosinophilic intranuclear inclusion bodies. PiHV infection was a secondary diagnosis or incidental finding in 35 cases. Most (55) cases had 1 (21), or up to 4 (34), other concurrent infections; the most common concurrent infections were pigeon circoviral infection (26), trichomonosis (24), aspergillosis (11), and colibacillosis (10)