Comparison of the arrhythmogenicity of acepromazine, xylazine and their combination in pentobarbital-anesthetized rats

Preanesthetic medications are often used in combination with injectable anesthetics in a variety of laboratory animal species. Simultaneous administration of sedative drugs, such as alpha2-adrenergic agonists and phenothiazines, provides muscle relaxation and reduces induction doses of anesthetic agents. However, these drugs may have significant cardiovascular and arrythmogenic effects which may contribute to anesthetic morbidity and mortality (Dyson et al., 1998).Results of previous reports indicate that xylazine, an alpha2-adrenergic agonist, may sensitize the myocardium to epinephrine in dogs anesthetized with halothane (Muir et al., 1975; Tranquilli et al., 1986), isoflurane (Tranquilli et al., 1988) and ketamine (Wright et al., 1987); whereas, acepromazine, a phenothiazine tranquilizer, possessed a protective action against catecholamine-induced arrhythmia in dogs anesthetized with halothane (Muir et al., 1975; Dyson & Pettifer, 1997). The male rat has been used as an animal model to determine the arrhythmic doses of epinephrine during halothane and isoflurane anesthesia (Laster et al., 1990). Rats are commonly used for scientific research and may be anesthetized using injectable or inhalant anesthetic agents for a variety of surgical procedures (Flecknell, 2009); however, injectable anesthetics are commonly preferred in a laboratory setting.Pentobarbital, as a short acting barbiturate anesthetic, is used for short surgical procedures in rats. It is rapidly absorbed following intraperitoneal administration and provide anesthesia for up to 60 min in the rat (Flecknell, 2009).The purpose of this study was to evaluate the effects of clinical doses of acepromazine, xylazine and their combination on the occurrence of epinephrine induced arrhythmia in rats under pentobarbital anesthesia

Complications and carcinogenic effects of mustard gas - A systematic review and meta-analysis in Iran

Background: Catastrophic effects of mustard gas as a chemical warfare agent have always been a major problem for those exposed to this agent. In this meta-analysis it was tried to evaluate carcinogenesis, ocular, cutaneous and respiratory complications of mustard gas exposure among Iranians who had been exposed to this agent during the Iran-Iraq war. Materials and Methods: In this meta-analysis, the required data were collected using keywords "mustard gas", "sulfur mustard", "cancer", "neoplasm", "respiratory complications", "ocular complications", "lung disease", "chronic complication", "eye", "skin", "cutaneous complication", "carcinogenesis" and their combination with keywords "Iran", "Iranian", "prevalence", "mortality" and their Farsi equivalent terms from the databases of SID, Iranmedex, Magiran, Pubmed, Science Direct, Google Search engine, Gray Literature and Reference of References. To determine the prevalence of each complication and perform meta-analysis, CMA: 2 (Comprehensive Meta-Analysis) software with a randomized model was used. Results: Of the 542 articles found, 7 national articles, consistent with the aims of this study were selected. Metaanalysis of seven papers revealed that cancer risk, especially cancer of the respiratory system was elevated, so that the relative risk (RR) of cancer role of mustard gas was inconsistent from 2/1 to 4 in this survey. Also prevalence of delayed skin disorders due to sulfur mustard was 94.6, pulmonary complications 94.5 and ocular complications 89.9. The incidence of various cancers in victims exposed to mustard gas was 1.7 worldwide where the rate was 2.2 in Iranian victims of the Iraq-Iran war. Conclusions: Based on present study the prevalence of delayed mustard gas related cutaneous, pulmonary and ocular complications is above 90 and risk of carcinogenesis is higher in comparison to worldwide statistics. This may suggest need for long-term and persistent follow-up and rehabilitation procedures es for populations exposed to this agent

Genome-wide analysis of alternative splicing events in Hordeum vulgare: highlighting retention of intron-based splicing and its possible function through network analysis

In this study, using homology mapping of assembled expressed sequence tags against the genomic data, we identified alternative splicing events in barley. Results demonstrated that intron retention is frequently associated with specific abiotic stresses. Network analysis resulted in discovery of some specific sub-networks between miRNAs and transcription factors in genes with high number of alternative splicing, such as cross talk between SPL2, SPL10 and SPL11 regulated by miR156 and miR157 families. To confirm the alternative splicing events, elongation factor protein (MLOC_3412) was selected followed by experimental verification of the predicted splice variants by Semi quantitative Reverse Transcription PCR (qRT-PCR). Our novel integrative approach opens a new avenue for functional annotation of alternative splicing through regulatory-based network discovery.Bahman Panahi, Seyed Abolghasem Mohammadi, Reyhaneh Ebrahimi Khaksefidi, Jalil Fallah Mehrabadi, Esmaeil Ebrahimi

Quantum simulation of frustrated magnetism in triangular optical lattices

Magnetism plays a key role in modern technology as essential building block of many devices used in daily life. Rich future prospects connected to spintronics, next generation storage devices or superconductivity make it a highly dynamical field of research. Despite those ongoing efforts, the many-body dynamics of complex magnetism is far from being well understood on a fundamental level. Especially the study of geometrically frustrated configurations is challenging both theoretically and experimentally. Here we present the first realization of a large scale quantum simulator for magnetism including frustration. We use the motional degrees of freedom of atoms to comprehensively simulate a magnetic system in a triangular lattice. Via a specific modulation of the optical lattice, we can tune the couplings in different directions independently, even from ferromagnetic to antiferromagnetic. A major advantage of our approach is that standard Bose-Einstein-condensate temperatures are sufficient to observe magnetic phenomena like N\'eel order and spin frustration. We are able to study a very rich phase diagram and even to observe spontaneous symmetry breaking caused by frustration. In addition, the quantum states realized in our spin simulator are yet unobserved superfluid phases with non-trivial long-range order and staggered circulating plaquette currents, which break time reversal symmetry. These findings open the route towards highly debated phases like spin-liquids and the study of the dynamics of quantum phase transitions.Comment: 5 pages, 4 figure

Ocular Graft Versus Host Disease Following Allogeneic Stem Cell Transplantation: A Review of Current Knowledge and Recommendations

Graft versus host disease (GVHD) is a common complication of allogeneic stem cell transplantation (allo-SCT). Ocular GVHD develops in approximately 40-60% of patients following allo-SCT and its most common clinical manifestations include keratoconjunctivitis sicca and cicatricial conjunctivitis. Ocular GVHD may lead to severe ocular surface disease, which can significantly diminish quality of life and restrict daily activities. It is thus important to monitor the condition closely since with timely diagnosis, irreversible damage can be avoided. The current review will focus on updated information regarding ocular GVHD

Marshall syndrome in children referred to specialist clinic of Imam Khomeini Hospital of Ilam, Iran, 2012

Periodic fever syndrome is a self-inflammatory disease. Since the disease is benign and self-limiting, the present study aimed to achieve a model to detect and differentiate it from other infectious diseases .In this study all children residing in Ilam who were suspected of Marshall Syndrome were examined. We chose a sample comprising children referred to Imam Hospital clinic of Ilam in 2012. Inclusion criteria consisted of more than three periods of fever without a source of infection, fever periods shorter than 5 days and repeated at intervals of about one month. The collected data were analyzed using SPSS software 16. We used both of descriptive and inferential statistics, Kolmogrov smirnov, Chi-square. Significance level of P ≤ 0.05 was considered. The average of patients' age was 4.9 ± 1.8 months and their gender perception was 85.7 male and 14.3 female. In this study the average age of symptoms emergence was 48.33 ± 23.25 month. The average of fever periods in surveyed patients was 4.09 ± 0.88 days (minimum 3 days & maximum 5 days) and the intervals between fever periods was 40.23 ± 16.84 in average. The applied treatments in this study were Prednisolone and Ttonsillectomy. There was significant relationship between age and the symptoms (P<0.007). By having a true perception of Marshall Syndrome using diagnosis criteria, we could prevent uncontrolled prescription of antibiotics and their possible side effects, and it is a positive step towards reducing healthcare costs

Quantum phase transition to unconventional multi-orbital superfluidity in optical lattices

Orbital physics plays a significant role for a vast number of important phenomena in complex condensed matter systems such as high-T$_c$ superconductivity and unconventional magnetism. In contrast, phenomena in superfluids -- especially in ultracold quantum gases -- are commonly well described by the lowest orbital and a real order parameter. Here, we report on the observation of a novel multi-orbital superfluid phase with a {\it complex} order parameter in binary spin mixtures. In this unconventional superfluid, the local phase angle of the complex order parameter is continuously twisted between neighboring lattice sites. The nature of this twisted superfluid quantum phase is an interaction-induced admixture of the p-orbital favored by the graphene-like band structure of the hexagonal optical lattice used in the experiment. We observe a second-order quantum phase transition between the normal superfluid (NSF) and the twisted superfluid phase (TSF) which is accompanied by a symmetry breaking in momentum space. The experimental results are consistent with calculated phase diagrams and reveal fundamentally new aspects of orbital superfluidity in quantum gas mixtures. Our studies might bridge the gap between conventional superfluidity and complex phenomena of orbital physics.Comment: 5 pages, 4 figure