15 research outputs found
The Technicon H*1™—An Automated Hematology Analyzer for Today and Tomorrow: Complete Blood Count Parameters
Comparative Sensitivity of Different Methods to Detect and Quantify Circulating Fibrinogen/Fibrin Split Products
Eight-parameter Automated Hematology Analyzers: Comparison of Two Flow Cytometric Systems
Structural Characterization of the Peroxodiiron(III) Intermediate Generated during Oxygen Activation by the W48A/D84E Variant of Ribonucleotide Reductase Protein R2 from Escherichia coli
Portable neuromodulation induces neuroplasticity to re-activate motor function recovery from brain injury: a high-density MEG case study
Background:
In a recent high-profile case study, we used functional magnetic resonance imaging (fMRI) to monitor improvements in motor function related to neuroplasticity following rehabilitation for severe traumatic brain injury (TBI). The findings demonstrated that motor function improvements can occur years beyond current established limits. The current study extends the functional imaging investigation to characterize neuromodulation effects on neuroplasticity to further push the limits.
Methods:
Canadian Soldier Captain (retired) Trevor Greene (TG) survived a severe open-TBI when attacked with an axe during a 2006 combat tour in Afghanistan. TG has since continued intensive daily rehabilitation to recover motor function, experiencing an extended plateau using conventional physical therapy. To overcome this plateau, we paired translingual neurostimulation (TLNS) with the continuing rehabilitation program.
Results:
Combining TLNS with rehabilitation resulted in demonstrable clinical improvements along with corresponding changes in movement evoked electro-encephalography (EEG) activity. High-density magneto-encephalography (MEG) characterized cortical activation changes in corresponding beta frequency range (27Â Hz). MEG activation changes corresponded with reduced interhemispheric inhibition in the post-central gyri regions together with increased right superior/middle frontal activation suggesting large scale network level changes.
Conclusions:
The findings provide valuable insight into the potential importance of non-invasive neuromodulation to enhance neuroplasticity mechanisms for recovery beyond the perceived limits of rehabilitation.Other UBCNon UBCReviewedFacult